公开(公告)号：US20150225415A1

公开(公告)日：2015-08-13

申请号：US14624033

申请日：2015-02-17

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Charles E. CHASE ,  Atsushi ENDO ,  Francis G. FANG ,  Jing LI

IPC: C07D493/20 ,  C07D493/18 ,  C07D493/08 ,  C07D307/28 ,  C07D307/33

CPC classification number: C07D493/20 ,  C07D307/20 ,  C07D307/26 ,  C07D307/28 ,  C07D307/33 ,  C07D309/16 ,  C07D405/06 ,  C07D405/14 ,  C07D493/04 ,  C07D493/08 ,  C07D493/18 ,  C07D493/22 ,  Y02P20/55

Abstract: Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.

公开(公告)号：US20190263826A1

公开(公告)日：2019-08-29

申请号：US16284405

申请日：2019-02-25

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Charles E. CHASE ,  Atsushi ENDO ,  Francis G. FANG ,  Jing LI

IPC: C07D493/20 ,  C07D405/14 ,  C07D493/04 ,  C07D493/08 ,  C07D307/33 ,  C07D307/28 ,  C07D493/18 ,  C07D405/06 ,  C07D309/16 ,  C07D307/26 ,  C07D307/20 ,  C07D493/22

Abstract: Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.

公开(公告)号：US20210347779A1

公开(公告)日：2021-11-11

申请号：US17141557

申请日：2021-01-05

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Wanjun ZHENG ,  Xiaojie ZHU ,  Hong DU ,  Maarten POSTEMA ,  Yimin JIANG ,  Jing LI ,  Robert YU ,  Hyeong-Wook CHOI ,  Jaemoon LEE ,  Francis G. FANG ,  Daniel CUSTAR

IPC: C07D487/04 ,  C07D519/00 ,  A61P35/00

Abstract: We provide compounds given by Formula I, which is shown in FIG. 3, or pharmaceutically acceptable salts thereof, as well as formulations thereof and methods of use of those compounds and formulations for treatment of cancer.

公开(公告)号：US20180037588A1

公开(公告)日：2018-02-08

申请号：US15787268

申请日：2017-10-18

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Charles E. CHASE ,  Atsushi ENDO ,  Francis G. FANG ,  Jing LI

IPC: C07D493/18 ,  C07D405/14 ,  C07D307/26 ,  C07D309/16 ,  C07D307/20 ,  C07D493/04 ,  C07D405/06

CPC classification number: C07D493/20 ,  C07D307/20 ,  C07D307/26 ,  C07D307/28 ,  C07D307/33 ,  C07D309/16 ,  C07D405/06 ,  C07D405/14 ,  C07D493/04 ,  C07D493/08 ,  C07D493/18 ,  C07D493/22 ,  Y02P20/55

Abstract: Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.

公开(公告)号：US20160214992A1

公开(公告)日：2016-07-28

申请号：US15092850

申请日：2016-04-07

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Charles E. CHASE ,  Atsushi ENDO ,  Francis G. FANG ,  Jing LI

IPC: C07D493/22 ,  C07D493/04

CPC classification number: C07D493/20 ,  C07D307/20 ,  C07D307/26 ,  C07D307/28 ,  C07D307/33 ,  C07D309/16 ,  C07D405/06 ,  C07D405/14 ,  C07D493/04 ,  C07D493/08 ,  C07D493/18 ,  C07D493/22 ,  Y02P20/55

Abstract: Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.