公开(公告)号：US20220112207A1

公开(公告)日：2022-04-14

申请号：US17421922

申请日：2020-01-09

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Francis G. FANG ,  Branko MITASEV ,  Jiong YANG

IPC: C07D491/147 ,  C07D403/06 ,  C07D487/04 ,  C07D405/14 ,  C07C311/18 ,  C07D307/33

Abstract: A method for the synthesis of diazabicyclo[6.2.0]decane compounds is provided. The synthesis proceeds by stereoselective synthesis of a chiral lactone followed by azetidine formation via a series of chemoselective reactions. Bicyclization results with the formation of diazobicyclo[6.2.0]decane related compounds.