公开(公告)号：US20220112207A1

公开(公告)日：2022-04-14

申请号：US17421922

申请日：2020-01-09

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Francis G. FANG ,  Branko MITASEV ,  Jiong YANG

IPC: C07D491/147 ,  C07D403/06 ,  C07D487/04 ,  C07D405/14 ,  C07C311/18 ,  C07D307/33

Abstract: A method for the synthesis of diazabicyclo[6.2.0]decane compounds is provided. The synthesis proceeds by stereoselective synthesis of a chiral lactone followed by azetidine formation via a series of chemoselective reactions. Bicyclization results with the formation of diazobicyclo[6.2.0]decane related compounds.

公开(公告)号：US20250092392A1

公开(公告)日：2025-03-20

申请号：US18557876

申请日：2022-04-28

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Vinod VATHIPADIEKAL ,  Branko MITASEV ,  Courtney EASLEY-NEAL ,  Hyeong Wook CHOI ,  Francis G. FANG ,  John WANG ,  Praveen VEMULA ,  Jung Hwa LEE

IPC: C12N15/113

Abstract: Novel antisense oligonucleotides that induce Exon-2 skipping in the CD33 gene during pre-mRNA splicing, and their use in the treatment of a neurodegenerative disease, such as Alzheimer's disease, are disclosed.

公开(公告)号：US20230279018A1

公开(公告)日：2023-09-07

申请号：US18188249

申请日：2023-03-22

Applicant: The Broad Institute, Inc. ,  President and Fellows of Harvard College ,  Eisai R&D Management Co., LTD.

Inventor： Eamon COMER ,  Bruno MELILLO ,  Francis G. FANG ,  Branko MITASEV

IPC: C07D487/04 ,  A61P33/06 ,  A61P33/02

CPC classification number: C07D487/04 ,  A61P33/06 ,  A61P33/02

Abstract: The invention provides agents that inhibit L-Phe in cytoplasmic phenylalanine tRNA-synthetase (cFRS), methods for identifying them, compositions comprising such agents, and therapeutic methods of using such agents.