公开(公告)号：US20160303058A1

公开(公告)日：2016-10-20

申请号：US15102046

申请日：2014-12-17

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Hiroyuki Higashiyama ,  Yuji Kazuta ,  Keisuke Hashimoto

IPC: A61K31/165

CPC classification number: A61K31/165 ,  A61K31/18

Abstract: A medicine comprising a 1-indansulfamides compound such as N-[(1S)-2,2,5,7-tetrafluoro-2,3-dihydro-1H-inden-1-yl]sulfamide, or N-[(1S)-2,2-difluoro-7-methyl-2,3-dihydro-1H-indene-1-yl]sulfamide or a pharmaceutically acceptable salt thereof, has an analgesic effects in the mouse hot-plate test and rat constriction nerve injury model and thus holds promise as a therapeutic agent for acute and chronic pain.

Abstract translation: 包含诸如N - [（1S）-2,2,5,7-四氟-2,3-二氢-1H-茚-1-基]磺酰胺的1-二氢化茚磺酰胺化合物或N - [（1S） -2,2-二氟-7-甲基-2,3-二氢-1H-茚-1-基]磺酰胺或其药学上可接受的盐在小鼠热板试验和大鼠收缩神经损伤模型中具有镇痛作用 因此作为急性和慢性疼痛的治疗剂具有希望。

公开(公告)号：US09610262B2

公开(公告)日：2017-04-04

申请号：US15102046

申请日：2014-12-17

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Hiroyuki Higashiyama ,  Yuji Kazuta ,  Keisuke Hashimoto

IPC: A61K31/165 ,  A61K31/18

CPC classification number: A61K31/165 ,  A61K31/18

Abstract: The present invention is directed to a method of treating pain comprising the administering the following 1-indansulfamide compounds: N-[(1S)-2,2,5,7-tetrafluoro-2,3-dihydro-1H-inden-1-yl]sulfamide, (−)-N-(7-chloro-2,2,5-trifluoro-2,3-dihydro-1H-inden-1-yl)sulfamide, N-[(1S)-2,2-difluoro-7-methyl-2,3-dihydro-1H-inden-1-yl]sulfamide, and N-[(1S)-2,2,5-trifluoro-7-methyl-2,3-dihydro-1H-inden-1-yl]sulfamide.