公开(公告)号：US20220031859A1

公开(公告)日：2022-02-03

申请号：US17312320

申请日：2019-12-12

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Nathan Fishkin ,  Thiwanka Samarakoon ,  James Palacino ,  Kenzo Arai ,  Yoshihiko Kotake ,  Shinya Okubo ,  Norio Murai ,  Masayuki Miyano

IPC: A61K47/68 ,  A61K47/60 ,  A61P35/00 ,  A61K39/395 ,  A61K39/00 ,  C12Q1/6886 ,  C07D407/06 ,  C07D405/14

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a herboxidiene splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. The herboxidiene itself is also claimed. Further claims are directed to its use, and to the use of a neoantigen, generated by the herboxidiene or its ADC, or a vaccine against this neoantigen.