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公开(公告)号:US20190100513A1
公开(公告)日:2019-04-04
申请号:US15529798
申请日:2016-11-17
发明人: Gregg F. Keaney , John Wang , Baudouin Gerard , Kenzo Arai , Xiang Liu , Guo Zhu Zheng , Kazunobu Kira , Parcharee Tivitmahaisoon , Sudeep Prajapati , Nicholas C. Gearhart , Yoshihiko Kotake , Satoshi Nagao , Regina Mikie Kanada Sonobe , Masayuki Miyano , Norio Murai , Silvia Buonamici , Lihua Yu , Eunice Sun Park , Betty Chan , Peter G. Smith , Michael P. Thomas , Ermira Pazolli , Kian Huat Lim , Atsushi Endo , Arani Chanda
IPC分类号: C07D405/14 , A61P35/02
摘要: The present disclosure provides a novel solid state form of pladienolide pyridine compounds, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.
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公开(公告)号:US09481669B2
公开(公告)日:2016-11-01
申请号:US14710687
申请日:2015-05-13
发明人: Gregg F. Keaney , John Wang , Baudouin Gerard , Kenzo Arai , Xiang Liu , Guo Zhu Zheng , Kazunobu Kira , Parcharee Tivitmahaisoon , Sudeep Prajapati , Nicholas C. Gearhart , Yoshihiko Kotake , Satoshi Nagao , Regina Mikie Kanada Sonobe , Masayuki Miyano , Norio Murai , Silvia Buonamici , Lihua Yu , Eunice Sun Park , Betty Chan , Peter G. Smith , Michael P. Thomas , Ermira Pazolli , Kian Huat Lim
IPC分类号: C07D405/06 , C07D405/14 , A61K31/496
CPC分类号: C07D405/14 , C07D405/06
摘要: The present invention provides novel pladienolide pyridine compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful.
摘要翻译: 本发明提供新颖的扁桃苷内酰吡啶化合物,含有这些化合物的药物组合物,以及使用该化合物作为治疗剂的方法。 这些化合物可用于治疗癌症,特别是癌症,其中靶向剪接体的试剂和其中的突变已知是有用的。
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公开(公告)号:US09975910B2
公开(公告)日:2018-05-22
申请号:US14904860
申请日:2014-07-18
发明人: Keigo Tanaka , Takashi Fukuyama , Norio Murai , Wataru Itano , Shinsuke Hirota , Daisuke Iida , Hiroshi Azuma
IPC分类号: C07D491/048 , C07F7/22 , C07D493/04 , C07D495/04 , C07D513/04 , C07F5/02
CPC分类号: C07F7/2208 , C07D491/048 , C07D493/04 , C07D495/04 , C07D513/04 , C07F5/02 , C07F5/025 , C07F5/027
摘要: A compound represented by the formula (I) or a salt thereof: wherein a ring Z is a 5 to 6-membered heteroaromatic ring having one or two heteroatoms in the ring; X1 is a hydrogen atom, a hydroxy group, a hydroxy C1-6 alkyl group, —B(OH)2, a boronate ester group, a cyclic boronate ester group, a boranyl group, a cyclic boranyl group, —BF3Mn1, —Sn(R12)(R13)(R14), a leaving group, a carboxy group, a formyl group, or —NR16R17; and X2 is a hydrogen atom or —CO2R18.
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公开(公告)号:US20150329528A1
公开(公告)日:2015-11-19
申请号:US14710687
申请日:2015-05-13
发明人: Gregg F. Keaney , John Wang , Baudouin Gerard , Kenzo Arai , Xiang Liu , Guo Zhu Zheng , Kazunobu Kira , Parcharee Tivitmahaisoon , Sudeep Prajapati , Nicholas C. Gearhart , Yoshihiko Kotake , Satoshi Nagao , Regina Mikie Kanada Sonobe , Masayuki Miyano , Norio Murai
IPC分类号: C07D405/14 , C07D405/06
CPC分类号: C07D405/14 , C07D405/06
摘要: The present invention provides novel pladienolide pyridine compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful.
摘要翻译: 本发明提供新颖的扁桃苷内酰吡啶化合物,含有这些化合物的药物组合物,以及使用该化合物作为治疗剂的方法。 这些化合物可用于治疗癌症,特别是癌症,其中靶向剪接体的试剂和其中的突变已知是有用的。
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公开(公告)号:US20220031859A1
公开(公告)日:2022-02-03
申请号:US17312320
申请日:2019-12-12
发明人: Nathan Fishkin , Thiwanka Samarakoon , James Palacino , Kenzo Arai , Yoshihiko Kotake , Shinya Okubo , Norio Murai , Masayuki Miyano
IPC分类号: A61K47/68 , A61K47/60 , A61P35/00 , A61K39/395 , A61K39/00 , C12Q1/6886 , C07D407/06 , C07D405/14
摘要: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a herboxidiene splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. The herboxidiene itself is also claimed. Further claims are directed to its use, and to the use of a neoantigen, generated by the herboxidiene or its ADC, or a vaccine against this neoantigen.
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公开(公告)号:US10745387B2
公开(公告)日:2020-08-18
申请号:US15529798
申请日:2016-11-17
发明人: Gregg F. Keaney , John Wang , Baudouin Gerard , Kenzo Arai , Xiang Liu , Guo Zhu Zheng , Kazunobu Kira , Parcharee Tivitmahaisoon , Sudeep Prajapati , Nicholas C. Gearhart , Yoshihiko Kotake , Satoshi Nagao , Regina Mikie Kanada Sonobe , Masayuki Miyano , Norio Murai , Silvia Buonamici , Lihua Yu , Eunice Sun Park , Betty Chan , Peter G. Smith , Michael P. Thomas , Ermira Pazolli , Kian Huat Lim , Atsushi Endo , Arani Chanda
IPC分类号: A61K31/496 , C07D295/182 , C07D405/14 , C07D405/06 , A61P35/02
摘要: The present disclosure provides a novel solid state form of pladienolide pyridine compounds having Formula I, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.
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公开(公告)号:US20160168176A1
公开(公告)日:2016-06-16
申请号:US14904860
申请日:2014-07-18
发明人: Keigo Tanaka , Takashi Fukuyama , Norio Murai , Wataru Itano , Shinsuke Hirota , Daisuke Iida , Hiroshi Azuma
IPC分类号: C07F7/22 , C07F5/02 , C07D495/04 , C07D513/04 , C07D491/048 , C07D493/04
CPC分类号: C07F7/2208 , C07D491/048 , C07D493/04 , C07D495/04 , C07D513/04 , C07F5/02 , C07F5/025 , C07F5/027
摘要: A compound represented by the formula (I) or a salt thereof: wherein a ring Z is a 5 to 6-membered heteroaromatic ring having one or two heteroatoms in the ring; X1 is a hydrogen atom, a hydroxy group, a hydroxy C1-6 alkyl group, —B(OH)2, a boronate ester group, a cyclic boronate ester group, a boranyl group, a cyclic boranyl group, —BF3Mn1, —Sn(R12)(R13)(R14), a leaving group, a carboxy group, a formyl group, or —NR16R17; and X2 is a hydrogen atom or —CO2R18.
摘要翻译: 由式(I)表示的化合物或其盐:其中环Z是环中具有一个或两个杂原子的5至6元杂芳环; X1是氢原子,羟基,羟基C1-6烷基,-B(OH)2,硼酸酯基,环状硼酸酯基,硼烷基,环状硼烷基,-BF3Mn1,-Sn (R 12)(R 13)(R 14),离去基团,羧基,甲酰基或-NR 16 R 17; X 2为氢原子或-CO 2 R 18。
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