公开(公告)号：US20240050462A1

公开(公告)日：2024-02-15

申请号：US17768283

申请日：2020-12-24

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Seiji TAKEMOTO ,  Shuntaro ARASE ,  Yuta SUZUKI

IPC: A61K31/713 ,  A61K9/107 ,  A61K9/127 ,  A61P13/02

CPC classification number: A61K31/713 ,  A61K9/107 ,  A61K9/1272 ,  A61P13/02

Abstract: Disclosed is a pharmaceutical composition comprising a lipid complex, wherein the lipid complex comprises a double-stranded ribonucleic acid comprising a sense strand consisting of a nucleotide sequence set forth in SEQ ID NO: 145 and an antisense strand consisting of a nucleotide sequence set forth in SEQ ID NO: 146, and a pH of a solution of the lipid complex is 5.0 or less, or 7.5 or more.