公开(公告)号：US20230151360A1

公开(公告)日：2023-05-18

申请号：US17791343

申请日：2021-01-28

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Yuta SUZUKI ,  Kazuto YAMAZAKI ,  Kenji KUBARA ,  Tomohiko TAMURA ,  Daisuke KUROTAKI

IPC: C12N15/11 ,  A61K47/54 ,  C12N15/113

CPC classification number: C12N15/111 ,  A61K47/549 ,  C12N15/113 ,  C12N2310/315 ,  C12N2310/351

Abstract: Disclosed is a nucleic acid complex or a pharmaceutically acceptable salt thereof; the nucleic acid complex represented by the formula (I), wherein X is CH2 or O; Y is a sugar ligand having mannose or GalNAc; n is an integer of 1 to 8; and Z is a group comprising an oligonucleotide.

公开(公告)号：US20240050462A1

公开(公告)日：2024-02-15

申请号：US17768283

申请日：2020-12-24

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Seiji TAKEMOTO ,  Shuntaro ARASE ,  Yuta SUZUKI

IPC: A61K31/713 ,  A61K9/107 ,  A61K9/127 ,  A61P13/02

CPC classification number: A61K31/713 ,  A61K9/107 ,  A61K9/1272 ,  A61P13/02

Abstract: Disclosed is a pharmaceutical composition comprising a lipid complex, wherein the lipid complex comprises a double-stranded ribonucleic acid comprising a sense strand consisting of a nucleotide sequence set forth in SEQ ID NO: 145 and an antisense strand consisting of a nucleotide sequence set forth in SEQ ID NO: 146, and a pH of a solution of the lipid complex is 5.0 or less, or 7.5 or more.

公开(公告)号：US20170360797A1

公开(公告)日：2017-12-21

申请号：US15527375

申请日：2015-11-17

Applicant: Epizyme, Inc. ,  Eisai R&D Management Co., Ltd.

Inventor： Heike KEILHACK ,  Brett TRUITT ,  Yuta SUZUKI ,  Tsukasa MURASE ,  Futoshi SHIKATA

IPC: A61K31/5377 ,  A61K9/20 ,  A61K9/00 ,  A61K9/28

Abstract: The present invention relates to pharmaceutical compositions comprising inhibitor(s) of human histone methyltransferase EZH2, and methods of cancer therapy using the EZH2 inhibitor(s).

公开(公告)号：US20210060030A1

公开(公告)日：2021-03-04

申请号：US16998144

申请日：2020-08-20

Applicant: Epizyme, Inc. ,  Eisai R&D Management Co., Ltd.

Inventor： Heike KEILHACK ,  Brett TRUITT ,  Yuta SUZUKI ,  Tsukasa MURASE ,  Futoshi SHIKATA

IPC: A61K31/5377 ,  A61K9/20 ,  A61K9/00 ,  A61K9/28

Abstract: The present invention relates to pharmaceutical compositions comprising inhibitor(s) of human histone methyltransferase EZH2, and methods of cancer therapy using the EZH2 inhibitor(s).