公开(公告)号：US20240148895A1

公开(公告)日：2024-05-09

申请号：US18237663

申请日：2023-08-24

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Masayuki MIYANO ,  Yuya NAKAZAWA ,  Kentaro ISO ,  Yuki YABE ,  Hirotatsu UMIHARA ,  Junichi TAGUCHI ,  Satoshi INOUE ,  Shuntaro TSUKAMOTO ,  Hiroyuki KOGAI ,  Atsumi YAMAGUCHI ,  Tsuyoshi AKAGI ,  Yohei MUKAI ,  Toshifumi HIRAYAMA ,  Masaki KATO ,  Toshiki MOCHIZUKI ,  Akihiko YAMAMOTO ,  Yuji YAMAMOTO ,  Takato SAKURADA

IPC: A61K47/68

CPC classification number: A61K47/6889 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6853 ,  A61K47/6855

Abstract: An antibody-drug conjugate represented by formula (I):






(where
Ab is an antibody,
X is a group represented by formula (X-1), formula (X-2) or formula (X-3):










(where

at the left represents the binding site with NH and

at the right represents the binding side with D),
D is a group represented by formula (D-1) or formula (D-2):










(where

represents the binding site with X), and
n is in the range of about 1 to about 8).