公开(公告)号：US11660275B2

公开(公告)日：2023-05-30

申请号：US16975865

申请日：2019-03-18

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Hiroyuki Higashiyama ,  Hisashi Wakita ,  Yoshimasa Ito ,  Yoshihide Osada

IPC: A61K31/18 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/506

CPC classification number: A61K31/18 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/506

Abstract: Provided is a combination agent that combines N-[(1S)-2,2,5,7-tetrafluoro-2,3-dihydro-1H-inden-1-yl]sulfamide with an AMPA-type glutamate receptor antagonist such as 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one or 2-fluoro-6-(3-fluoro-8-oxo-7-(pyridin-3-yl)-7,8-dihydro-6H-pyrano[3,2-b:5,4-b′]dipyridin-9-yl)benzonitrile, and it has potential for use as a therapeutic agent for epilepsy.