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公开(公告)号：US20140012011A1
公开(公告)日：2014-01-09
申请号：US13947593
申请日：2013-07-22
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Francis G. Fang , James E. Foy , Lynn Hawkins , Charles Lemelin , Andre LesCarbeau , Xiang Niu , Kuo-Ming Wu
IPC: C07D263/14
CPC classification number: C07D263/14 , C07C217/28 , C07C271/16 , C07F9/091 , C07F9/1411 , C07F9/2408
Abstract: The present invention provides methods for preparing TLR-4 receptor agonist E6020: and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates.
Abstract translation: 本发明提供了制备TLR-4受体激动剂E6020及其立体异构体的方法，当与抗原如用于细菌和病毒疾病的疫苗共同施用时，该化合物可用作免疫佐剂。 还提供了合成中间体。
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公开(公告)号：US08962857B2
公开(公告)日：2015-02-24
申请号：US14269659
申请日：2014-05-05
Applicant: Eisai R&D Management Co.. Ltd.
Inventor： Francis G. Fang , James E. Foy , Lynn Hawkins , Charles Lemelin , Andre LesCarbeau , Xiang Niu , Kuo-Ming Wu
IPC: C07D263/02
CPC classification number: C07D263/14 , C07C217/28 , C07C271/16 , C07F9/091 , C07F9/1411 , C07F9/2408
Abstract: The present invention provides methods for preparing TLR-4 receptor agonist E6020: and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates.
Abstract translation: 本发明提供了制备TLR-4受体激动剂E6020及其立体异构体的方法，当与抗原如用于细菌和病毒疾病的疫苗共同施用时，该化合物可用作免疫佐剂。 还提供了合成中间体。
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公开(公告)号：US20140323739A1
公开(公告)日：2014-10-30
申请号：US14269659
申请日：2014-05-05
Applicant: Eisai R&D Management Co.. Ltd.
Inventor： Francis G. Fang , James E. Foy , Lynn Hawkins , Charles Lemelin , Andre LesCarbeau , Xiang Niu , Kuo-Ming Wu
IPC: C07D263/14
CPC classification number: C07D263/14 , C07C217/28 , C07C271/16 , C07F9/091 , C07F9/1411 , C07F9/2408
Abstract: The present invention provides methods for preparing TLR-4 receptor agonist E6020: and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates.
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公开(公告)号：US08754236B2
公开(公告)日：2014-06-17
申请号：US13947593
申请日：2013-07-22
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Francis G. Fang , James E. Foy , Lynn Hawkins , Charles Lemelin , Andre LesCarbeau , Xiang Niu , Kuo-Ming Wu
IPC: C07D263/08
CPC classification number: C07D263/14 , C07C217/28 , C07C271/16 , C07F9/091 , C07F9/1411 , C07F9/2408
Abstract: The present invention provides methods for preparing TLR-4 receptor agonist E6020: and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates.
Abstract translation: 本发明提供了制备TLR-4受体激动剂E6020及其立体异构体的方法，当与抗原如用于细菌和病毒疾病的疫苗共同施用时，该化合物可用作免疫佐剂。 还提供了合成中间体。
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