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1.发明申请Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response 有权免疫调节寡核苷酸（IRO）化合物调节基于类似受体的免疫应答公开(公告)号：US20090060898A1
公开(公告)日：2009-03-05
申请号：US11549048
申请日：2006-10-12
申请人： Ekambar R. Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar R. Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
IPC分类号： A61K31/7088 , A61K39/395 , A61P37/08 , A61P31/00 , A61P29/00 , A61P17/00 , A61P11/06
CPC分类号： C12N15/117 , A61K9/0019 , A61K31/713 , A61K45/06 , A61K48/00 , A61K2039/55561 , C12N2310/17 , C12N2310/314 , C12N2310/321 , C12N2310/33 , C12N2310/335 , C12N2320/31
摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
摘要翻译： 本发明提供作为TLR拮抗剂的新型免疫调节寡核苷酸（IRO）及其使用方法。 这些IRO具有独特的序列，其响应于TLR配体或TLR激动剂抑制或抑制TLR介导的信号传导。 该方法可用于预防和治疗癌症，自身免疫性疾病，气道炎症，炎症性疾病，感染性疾病，皮肤病，变态反应，哮喘或由病原体引起的疾病。
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公开(公告)号：US08357665B2
公开(公告)日：2013-01-22
申请号：US11549048
申请日：2006-10-12
申请人： Ekambar R. Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar R. Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
CPC分类号： C12N15/117 , A61K9/0019 , A61K31/713 , A61K45/06 , A61K48/00 , A61K2039/55561 , C12N2310/17 , C12N2310/314 , C12N2310/321 , C12N2310/33 , C12N2310/335 , C12N2320/31
摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
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3.发明申请IMMUNE REGULATORY OLIGONUCLEOTIDE (IRO) COMPOUNDS TO MODULATE TOLL-LIKE RECEPTOR BASED IMMUNE RESPONSE 有权免疫调节寡核苷酸（IRO）化合物，以调节基于类似感受器的免疫应答公开(公告)号：US20090098063A1
公开(公告)日：2009-04-16
申请号：US12244199
申请日：2008-10-02
申请人： Ekambar R. Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar R. Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
IPC分类号： A61K31/711 , A61K39/395 , A61K9/12 , A61K8/73
CPC分类号： A61K48/00 , A61K31/711 , A61K39/12 , A61K2039/55561 , C12N2730/10134 , C12N2740/16011 , A61K2300/00
摘要： The invention provides the use of immune regulatory oligonucleotides (IRO) as antagonist of TLRs in the prevention and treatment of a disease caused by a pathogen, for example, a DNA or RNA virus.
摘要翻译： 本发明提供免疫调节寡核苷酸（IRO）作为TLR拮抗剂在预防和治疗由病原体例如DNA或RNA病毒引起的疾病中的用途。
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4.发明申请IMMUNE REGULATORY OLIGONUCLEOTIDE (IRO) COMPOUNDS TO MODULATE TOLL-LIKE RECEPTOR BASED IMMUNE RESPONSE 有权免疫调节寡核苷酸（IRO）化合物，以调节基于类似感受器的免疫应答公开(公告)号：US20080089883A1
公开(公告)日：2008-04-17
申请号：US11743876
申请日：2007-05-03
申请人： Ekambar R. Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar R. Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
IPC分类号： A61K31/7052 , A61K38/00 , A61K39/00 , A61K39/395 , A61P1/00 , A61P19/02 , A61P3/10 , A61P33/02
CPC分类号： A61K39/292 , A61K31/7052 , A61K39/12 , A61K2039/55561 , A61K2039/57 , C12N2730/10134 , Y02A50/412
摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
摘要翻译： 本发明提供作为TLR拮抗剂的新型免疫调节寡核苷酸（IRO）及其使用方法。 这些IRO具有独特的序列，其响应于TLR配体或TLR激动剂抑制或抑制TLR介导的信号传导。 该方法可用于预防和治疗癌症，自身免疫性疾病，气道炎症，炎症性疾病，感染性疾病，皮肤病，变态反应，哮喘或由病原体引起的疾病。
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5.发明申请Novel synthetic agonists of toll-like receptors containing CG dinucleotide modifications 审中-公开含有CG二核苷酸修饰的toll样受体的新型合成激动剂公开(公告)号：US20080279785A1
公开(公告)日：2008-11-13
申请号：US11641590
申请日：2006-12-19
申请人： Ekambar R. Kandimalla , Malikarjuna Reddy Putta , Yukui Li , Lakshmi Bhagat , FuGang Zhu , Sudhir Agrawal
发明人： Ekambar R. Kandimalla , Malikarjuna Reddy Putta , Yukui Li , Lakshmi Bhagat , FuGang Zhu , Sudhir Agrawal
IPC分类号： A61K9/12 , C07H21/02 , A61K39/395 , A61K39/00 , C07H21/04 , A61P35/00 , A61K39/35 , A61K38/02 , A61K31/711
CPC分类号： C12N15/117 , A61K39/39 , A61K2039/55561 , C07H21/02 , C12N2310/17 , C12N2310/3183 , C12N2310/334 , C12N2310/336
摘要： The invention relates to the therapeutic use of oligonucleotides as immune modulatory agents in immunotherapy applications. More particularly, the invention provides immune modulatory oligonucleotide compositions for use in methods for generating an immune response or for treating a patient in need of immune modulation. The immune modulatory oligonucleotides of the invention preferably comprise novel pyrimidines and purines.
摘要翻译： 本发明涉及在免疫治疗应用中寡核苷酸作为免疫调节剂的治疗用途。 更具体地，本发明提供用于产生免疫应答的方法或用于治疗需要免疫调节的患者的免疫调节寡核苷酸组合物。 本发明的免疫调节寡核苷酸优选包含新的嘧啶和嘌呤。
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公开(公告)号：US08361986B2
公开(公告)日：2013-01-29
申请号：US13156140
申请日：2011-06-08
申请人： Ekambar R. Kandimalla , Mallikarjuna Putta , Daqing Wang , Dong Yu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar R. Kandimalla , Mallikarjuna Putta , Daqing Wang , Dong Yu , Lakshmi Bhagat , Sudhir Agrawal
CPC分类号： A61K31/711 , A61K39/39
摘要： The invention relates to synthetic chemical compositions that are useful for modulation of Toll-Like Receptor (TLR)-mediated immune responses. In particular, the invention relates to agonists of Toll-Like Receptor 9 (TLR9) that generate unique cytokine and chemokine profiles.
摘要翻译： 本发明涉及可用于调节Toll样受体（TLR）介导的免疫应答的合成化学组合物。 特别地，本发明涉及产生独特细胞因子和趋化因子分布的Toll样受体9（TLR9）的激动剂。
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公开(公告)号：US20090053206A1
公开(公告)日：2009-02-26
申请号：US12183439
申请日：2008-07-31
申请人： Ekambar R. Kandimalla , Mallikarjuna Putta , Daqing Wang , Dong Yu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar R. Kandimalla , Mallikarjuna Putta , Daqing Wang , Dong Yu , Lakshmi Bhagat , Sudhir Agrawal
IPC分类号： A61K39/395 , C07H21/04 , A61K31/711 , A61K39/35 , A61K39/00
CPC分类号： A61K31/711 , A61K39/39
摘要： The invention relates to synthetic chemical compositions that are useful for modulation of Toll-Like Receptor (TLR)-mediated immune responses. In particular, the invention relates to agonists of Toll-Like Receptor 9 (TLR9) that generate unique cytokine and chemokine profiles.
摘要翻译： 本发明涉及可用于调节Toll样受体（TLR）介导的免疫应答的合成化学组合物。 特别地，本发明涉及产生独特细胞因子和趋化因子分布的Toll样受体9（TLR9）的激动剂。
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8.发明授权公开(公告)号：US07569554B2
公开(公告)日：2009-08-04
申请号：US10846167
申请日：2004-05-14
申请人： Ekambar R. Kandimalla , Sudhir Agrawal , Daqing Wang , Lakshmi Bhagat , Dong Yu
发明人： Ekambar R. Kandimalla , Sudhir Agrawal , Daqing Wang , Lakshmi Bhagat , Dong Yu
IPC分类号： A61K39/395 , A61K31/7105 , A61K31/7115 , A61K31/7125
CPC分类号： A61K39/0011 , A61K39/39558 , A61K2039/55561 , C07K16/2887 , C07K16/32 , C07K2317/24 , A61K2300/00
摘要： The invention relates to the therapeutic use of immunostimulatory oligonucleotides and/or immunomers in combination with chemotherapeutic agents to provide a synergistic therapeutic effect.
摘要翻译： 本发明涉及免疫刺激性寡核苷酸和/或免疫组合物与化学治疗剂组合以提供协同治疗效果的治疗用途。
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9.发明授权公开(公告)号：US07875594B2
公开(公告)日：2011-01-25
申请号：US12020694
申请日：2008-01-28
申请人： Ekambar R. Kandimalla , Sudhir Agrawal , Daqing Wang , Lakshmi Bhagat , Dong Yu
发明人： Ekambar R. Kandimalla , Sudhir Agrawal , Daqing Wang , Lakshmi Bhagat , Dong Yu
IPC分类号： A61K39/395
CPC分类号： A61K39/0011 , A61K39/39558 , A61K2039/55561 , C07K16/2887 , C07K16/32 , C07K2317/24 , A61K2300/00
摘要： The invention relates to the therapeutic use of immunostimulatory oligonucleotides and/or immunomers in combination with chemotherapeutic agents to provide a synergistic therapeutic effect.
摘要翻译： 本发明涉及免疫刺激性寡核苷酸和/或免疫组合物与化学治疗剂组合以提供协同治疗效果的治疗用途。
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10.发明申请SYNERGISTIC TREATMENT OF CANCER USING IMMUNOMERS IN CONJUNCTION WITH CHEMOTHERAPEUTIC AGENTS 有权使用免疫调节剂联合化疗药物治疗癌症的协同治疗公开(公告)号：US20080206265A1
公开(公告)日：2008-08-28
申请号：US12020694
申请日：2008-01-28
申请人： Ekambar R. Kandimalla , Sudhir Agrawal , Daqing Wang , Lakshmi Bhagat , Dong Yu
发明人： Ekambar R. Kandimalla , Sudhir Agrawal , Daqing Wang , Lakshmi Bhagat , Dong Yu
IPC分类号： A61K39/00 , A61K31/7052 , A61P35/00
CPC分类号： A61K39/0011 , A61K39/39558 , A61K2039/55561 , C07K16/2887 , C07K16/32 , C07K2317/24 , A61K2300/00
摘要： The invention relates to the therapeutic use of immunostimulatory oligonucleotides and/or immunomers in combination with chemotherapeutic agents to provide a synergistic therapeutic effect.
摘要翻译： 本发明涉及免疫刺激性寡核苷酸和/或免疫组合物与化学治疗剂组合以提供协同治疗效果的治疗用途。
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