公开(公告)号：US20080108139A1

公开(公告)日：2008-05-08

申请号：US11929055

申请日：2007-10-30

申请人： Elazar Rabbani ,  Jannis Stavrianopoulos ,  James Donegan ,  Dakai Liu ,  Norman Kelker ,  Dean Engelhardt

发明人： Elazar Rabbani ,  Jannis Stavrianopoulos ,  James Donegan ,  Dakai Liu ,  Norman Kelker ,  Dean Engelhardt

IPC分类号： C07H21/04 ,  C12N15/00

CPC分类号： C12N15/1132 ,  C07K14/005 ,  C07K14/62 ,  C12N9/1247 ,  C12N15/87 ,  C12N2740/16322 ,  C12Q1/6897 ,  C12Q1/703 ,  C12Q2525/301 ,  C12Q2525/307

摘要： The present invention provides an array of compositions useful for effecting and/or exhibiting changes in biological functioning and processing within cells and in biological systems containing such cells. In effect, these compositions combine chemical modifications and/or ligand additions with biological functions. The chemical modifications and/or ligand additions provide additional characteristics to the compositions without interfering substantially with their biological function. Such additional characteristics include nuclease resistance, targeting specific cells or specific cell receptors localizing to specific sites within cells and augmenting interactions between the compositions and target cells of interest as well as decreasing such interactions when desired. Also provided by the present invention are processes and kits.

摘要翻译： 本发明提供了一组组合物，其用于在细胞内和含有这种细胞的生物系统中实现和/或表现出生物功能和加工中的变化。 实际上，这些组合物将化学修饰和/或配体添加与生物学功能相结合。 化学修饰和/或配体添加为组合物提供额外的特征，而不会基本上干扰它们的生物学功能。 这样的附加特征包括核酸酶抗性，靶向特定细胞或定位于细胞内特定位点的特定细胞受体，并且增加组合物和靶细胞之间的相互作用，并且当需要时减少这种相互作用。 本发明还提供了方法和试剂盒。