公开(公告)号：US20080096965A1

公开(公告)日：2008-04-24

申请号：US11574751

申请日：2005-07-28

申请人： Elena Barbanti ,  Florian Thaler ,  Carla Caccia ,  Ruggero Fariello ,  Partricia Salvati

发明人： Elena Barbanti ,  Florian Thaler ,  Carla Caccia ,  Ruggero Fariello ,  Partricia Salvati

IPC分类号： A61K31/195 ,  A61P29/00

CPC分类号： C07C237/06 ,  A61K31/00 ,  A61K31/165 ,  A61K45/06 ,  A61K2300/00

摘要： The invention relates to the use of selected (R)-2-[(halobenzyloxy)benzylamino]-propanamides and the pharmaceutically acceptable salts thereof for the manufacture of medicament, that are selectively active assodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, pain, migraine, periferal diseases, cardiovascular diseases, inflammatory processes affecting all body systems, disorders affecting skin and related tissues, disorders of the respiratory system, disorders of the immune and endocrinological systems, gastrointestinal, urogenital, metabolic and seizure disorders, where the above mechanisms have been described as playing a pathological role.

摘要翻译： 本发明涉及选择的（R）-2 - [（卤代苄氧基）苄氨基] - 丙酰胺及其药学上可接受的盐在制备药物中的用途，所述药物是选择性活性的脯氨酸和/或钙通道调节剂，因此可用于预防 ，减轻和治愈各种病症，包括疼痛，偏头痛，周围疾病，心血管疾病，影响所有身体系统的炎症过程，影响皮肤和相关组织的病症，呼吸系统疾病，免疫和内分泌系统疾病， 胃肠道，泌尿生殖，代谢和发作障碍，其中上述机制被描述为发挥病理作用。