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8 条记录 (耗时 0.045 秒)

    METHODS FOR TREATING EYE DISORDERS
    2.
    发明申请
    METHODS FOR TREATING EYE DISORDERS 有权
    治疗眼病的方法

    公开(公告)号：US20110229557A1

    公开(公告)日：2011-09-22

    申请号：US13062161

    申请日：2009-10-22

    申请人： Elena Feinstein ,  Evgenia Alpert ,  Igor Mett ,  Amir Bar-Ilan ,  Igor Spivak ,  Hagar Kalinski ,  Netanja Slager

    发明人： Elena Feinstein ,  Evgenia Alpert ,  Igor Mett ,  Amir Bar-Ilan ,  Igor Spivak ,  Hagar Kalinski ,  Netanja Slager

    IPC分类号： A61K31/713 ,  C07H21/02 ,  A61K9/14 ,  A61K9/127 ,  A61P27/02

    CPC分类号： C12N15/113 ,  A61K9/0048 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2320/30

    摘要： The present invention relates to compositions and methods for inhibiting loss of a retinal ganglion cell in a subject, comprising non-invasively applying to the surface of the eye of the subject an ophthalmic composition comprising a therapeutically effective amount of at 5 least one siRNA which down regulates expression of a target gene associated with loss of the retinal ganglion cell, thereby inhibiting loss of the retinal ganglion cell in the subject. The methods of the invention also relate to the use of chemically modified siRNA compounds possessing structural motifs which down-regulate the expression of human genes expressed in retinal tissue in the mammalian eye.

    摘要翻译： 本发明涉及用于抑制受试者中视网膜神经节细胞损失的组合物和方法，包括非侵入性地施用于受试者眼睛表面的眼科组合物，其包含治疗有效量的至少一种siRNA，所述siRNA下降 调节与视网膜神经节细胞丧失相关的靶基因的表达，从而抑制受试者中视网膜神经节细胞的损失。 本发明的方法还涉及具有下调哺乳动物眼睛中视网膜组织中表达的人类基因表达的结构基序的化学修饰的siRNA化合物的用途。

    Compositions and methods for treatment of ear disorders
    3.
    发明授权
    Compositions and methods for treatment of ear disorders 有权
    用于治疗耳部疾病的组合物和方法

    公开(公告)号：US09089591B2

    公开(公告)日：2015-07-28

    申请号：US13867837

    申请日：2013-04-22

    申请人： Evgenia Alpert ,  Igor Spivak ,  Amir Bar-Ilan

    发明人： Evgenia Alpert ,  Igor Spivak ,  Amir Bar-Ilan

    IPC分类号： A61K48/00 ,  C07H21/02 ,  C07H21/04 ,  A61K31/713 ,  A61K9/00 ,  C12N15/113

    CPC分类号： A61K31/713 ,  A61K9/0046 ,  C12N15/113 ,  C12N2310/14

    摘要： The present invention relates to pharmaceutical compositions useful for topical, non-invasive delivery of an oligonucleotide to the ear and to methods for the treatment of an ear disorder, including hearing loss arising from chemical-induced ototoxicity, acoustic trauma and presbycusis; and microbial infections. The method comprises topically administering to the ear of a subject in need thereof a pharmaceutical composition comprising an inhibitory oligonucleotide, a permeability enhancer and a pharmaceutically acceptable carrier, wherein the oligonucleotide reduces or inhibits expression of a gene associated with the ear disorder in the subject.

    摘要翻译： 本发明涉及可用于向耳部局部非侵入性递送寡核苷酸的药物组合物和用于治疗耳朵疾病的方法，包括由化学引起的耳毒性，声学创伤和老年性耳聋引起的听力损失; 和微生物感染。 该方法包括向有需要的受试者的耳部局部施用包含抑制性寡核苷酸，通透性增强剂和药学上可接受的载体的药物组合物，其中所述寡核苷酸降低或抑制与受试者相关的耳部疾病相关基因的表达。

    COMPOSITIONS AND METHODS FOR TREATMENT OF EAR DISORDERS
    4.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATMENT OF EAR DISORDERS 审中-公开
    用于治疗严重疾病的组合物和方法

    公开(公告)号：US20140066493A1

    公开(公告)日：2014-03-06

    申请号：US13867837

    申请日：2013-04-22

    申请人： Evgenia Alpert ,  Igor Spivak ,  Amir Bar-Ilan

    发明人： Evgenia Alpert ,  Igor Spivak ,  Amir Bar-Ilan

    IPC分类号： A61K31/713

    CPC分类号： A61K31/713 ,  A61K9/0046 ,  C12N15/113 ,  C12N2310/14

    摘要： The present invention relates to pharmaceutical compositions useful for topical, non-invasive delivery of an oligonucleotide to the ear and to methods for the treatment of an ear disorder, including hearing loss arising from chemical-induced ototoxicity, acoustic trauma and presbycusis; and microbial infections. The method comprises topically administering to the ear of a subject in need thereof a pharmaceutical composition comprising an inhibitory oligonucleotide, a permeability enhancer and a pharmaceutically acceptable carrier, wherein the oligonucleotide reduces or inhibits expression of a gene associated with the ear disorder in the subject.

    摘要翻译： 本发明涉及可用于向耳部局部非侵入性递送寡核苷酸的药物组合物和用于治疗耳朵疾病的方法，包括由化学引起的耳毒性，声学创伤和老年性耳聋引起的听力损失; 和微生物感染。 该方法包括向有需要的受试者的耳部局部施用包含抑制性寡核苷酸，通透性增强剂和药学上可接受的载体的药物组合物，其中所述寡核苷酸降低或抑制与受试者相关的耳部疾病相关基因的表达。

    COMPOSITIONS AND METHODS FOR TREATMENT OF EAR DISORDERS
    8.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATMENT OF EAR DISORDERS 有权
    用于治疗严重疾病的组合物和方法

    公开(公告)号：US20110142917A1

    公开(公告)日：2011-06-16

    申请号：US12994725

    申请日：2009-06-07

    申请人： Egvenia Alpert ,  Igor Spivak ,  Amir Bar-Ilan

    发明人： Egvenia Alpert ,  Igor Spivak ,  Amir Bar-Ilan

    IPC分类号： A61K31/713 ,  A61K31/7088 ,  A61K9/127 ,  A61K33/24 ,  A61P27/16

    CPC分类号： A61K31/713 ,  A61K9/0046 ,  C12N15/113 ,  C12N2310/14

    摘要： The present invention relates to pharmaceutical compositions useful for topical, non-invasive delivery of an oligonucleotide to the ear and to methods for the treatment of an ear disorder, including hearing loss arising from chemical-induced ototoxicity, acoustic trauma and presbycusis; and microbial infections. The method comprises topically administering to the ear of a subject in need thereof a pharmaceutical composition comprising an inhibitory oligonucleotide, a permeability enhancer and a pharmaceutically acceptable carrier, wherein the oligonucleotide reduces or inhibits expression of a gene associated with the ear disorder in the subject.

    摘要翻译： 本发明涉及可用于向耳部局部非侵入性递送寡核苷酸的药物组合物和用于治疗耳朵疾病的方法，包括由化学引起的耳毒性，声学创伤和老年性耳聋引起的听力损失; 和微生物感染。 该方法包括向有需要的受试者的耳部局部施用包含抑制性寡核苷酸，通透性增强剂和药学上可接受的载体的药物组合物，其中所述寡核苷酸降低或抑制与受试者相关的耳部疾病相关基因的表达。