摘要:
The present invention relates to compositions and methods for inhibiting loss of a retinal ganglion cell in a subject, comprising non-invasively applying to the surface of the eye of the subject an ophthalmic composition comprising a therapeutically effective amount of at 5 least one siRNA which down regulates expression of a target gene associated with loss of the retinal ganglion cell, thereby inhibiting loss of the retinal ganglion cell in the subject. The methods of the invention also relate to the use of chemically modified siRNA compounds possessing structural motifs which down-regulate the expression of human genes expressed in retinal tissue in the mammalian eye.
摘要:
Methods and apparatus are provided for stabilizing the phase and gain of an amplifier in a power pooling arrangement. A pilot signal combining a reference carrier frequency with a reference sideband frequency is passed through the amplifier via an adjustable phase shifter and an adjustable attenuator in the amplifier input line. A portion of the amplified pilot signal is coupled from the output of the amplifier and mixed with the reference frequency. The remaining audio frequency signal is compared to a reference (input) audio signal to determine phase and gain changes during amplification in the amplifier. Phase and gain control signals are developed from this comparison, and are fed back to the adjustable phase shifter and adjustable attenuator, respectively, in order to compensate an incoming signal for phase and gain variations in the amplifier.
摘要:
A beam-forming network (98) employs one or a plurality of first transmission delay lines (168, 170, 172, 174) for receiving transmit signals (T1-T4) applied thereto, and a plurality of second transmission lines (176), which serve as line summers. Each of the first transmission delay lines has first and second portions (168a, 168b; 170a, 170b; 172a; 172b; 174a; 174b) spaced apart from one another so as to define first and second levels displaced from one another. The set of second transmission lines (176) are arranged in first and second subsets (176a, 176b) which are respectively disposed adjacent to the first and second levels and respectively associated with the first and second portions of the first lines, such that the first subset of second lines is coupled to the first portion of the first lines, and the second subset of the second lines is coupled to the second portion of the first lines. Further, selected ones of the first subset of second lines are disposed adjacent to selected ones of the second subset of second lines in order to facilitate simple and orderly routing of transmission lines (126, 128, 130) between the beam-forming network and a novel equal power amplifier system (100) described herein.
摘要:
A beam-forming network (98) employs one or a plurality of first transmission delay lines (168, 170, 172, 174) for receiving transmit signals (T1-T4) applied thereto, and a plurality of second transmission lines (176), which serve as line summers. Each of the first transmission delay lines has first and second portions (168a, 168b; 170a, 170b; 172a, 172b; 174a, 174b) spaced apart from one another so as to define first and second levels displaced from one another. The set of second transmission lines (176) are arranged in first and second subsets (176a, 176b) which are respectively disposed adjacent to the first and second levels and respectively associated with the first and second portions of the first lines, such that the first subset of second lines is coupled to the first portion of the first lines, and the second subset of the second lines is coupled to the second portion of the first lines. Further, selected ones of the first subset of second lines are disposed adjacent to selected ones of the second subset of second lines in order to facilitate simple and orderly routing of transmission lines (126, 128, 130) between the beam-forming network and a novel equal power amplifier system (100) described herein.
摘要:
An improved method for designing sector beam antennas. The method is used to provide a sector beam antenna having a feed horn with a cross sectional azimuth dimension and a cross sectional elevational dimension which are optimized to irradiate a reflector to transmit a signal over a coverage area such that the gain-area-product of the transmitted signal is maximized.
摘要:
A system for communications between a lunar or planetary surface and the Earth may include a first communications satellite adapted to be positioned in a predetermined orbit relative to a celestial body. A first antenna may be mounted on the first communications satellite. The first antenna may include a predetermined beam shape for communications between the first communications satellite and an asset on the lunar or planetary surface. A second antenna may also be mounted on the first communications satellite. The second antenna may include a selected beam shape for communications between the first communications satellite and the Earth. A communications system may be included for relaying communications between the first and second antennas.
摘要:
A method of managing information comprises generating a categorized document base. Generating the document base comprises providing a pre-existing classification of things other than documents, providing a source collection of documents, and automatically assessing the documents using Information Retrieval techniques to assign at least some of the documents to one or more taxa of the classification. For each taxon in the classification one or more numerical scores are assigned, based at least in part on a composition, makeup or constitution of the documents assigned to the taxon of the categorized document base.
摘要:
A transcribed non-naturally occurring RNA molecule comprising a desired RNA molecule, wherein the 3′ region of the RNA is able to base-pair with at least 8 bases at the 5′ terminus of the same RNA molecule.
摘要:
Nucleic acid catalysts, method of screening/selection for nucleic acid catalysts, synthesis of ribozyme libraries and discovery of gene sequences involved in a biological process are described.