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公开(公告)号：US11787834B2
公开(公告)日：2023-10-17
申请号：US17700943
申请日：2022-03-22
发明人： Adel Ahmed Rashad Ahmed , Joshua Ryan Clayton , Jose Eduardo Lopez , William Thomas McMillen , Ryan Edward Stites , Takako Wilson , Jacqueline Mary Wurst
IPC分类号： C07J71/00
CPC分类号： C07J71/0031
摘要： The present invention provides a compound of Formula I:
wherein R is H or
R1 is H, halogen, C1-C3 alkyl, C3-C6 cycloalkyl, C1-C3 alkoxy, C2-C3 alkenyl, OCF3,
R2 is H, halogen, C1-C3 alkyl, C1-C3 alkoxy, or C2-C4 alkenyl;
R3 is NH2, or CH2NH2; and
X is O, OCH2, OCH2CH2, OCH(CH3), CH2O, SCH2, CH2S, CH2, NHCH2, CH2NH, N(CH3)CH2, CH2CH2, C≡C, or a bond, wherein X is connected to phenyl ring A at the ortho or the meta position, or a pharmaceutically acceptable salt thereof, wherein the compound of Formula I, or pharmaceutically acceptable salt thereof is useful for treating autoimmune and inflammatory diseases, such as atopic dermatitis and rheumatoid arthritis.-
公开(公告)号：US20240173425A1
公开(公告)日：2024-05-30
申请号：US18338468
申请日：2023-06-21
发明人： Forest Hoyt Andrews , Joshua Ryan Clayton , Ross Edward Fellows , Bo Ma , Ying Tang , Jacqueline Mary Wurst , Pia Pauliina Yachi , Chiao-Wen Yang
CPC分类号： A61K47/6849 , A61K47/6803 , A61K47/6889 , A61P37/06 , C07K1/1077 , C07K16/2803 , A61K2039/505 , C07K2317/92
摘要： The present disclosure provides human CD33 antibodies and antibody glucocorticoid receptor agonist conjugates and methods of using the conjugates for the treatment of myeloid cell associated diseases.
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公开(公告)号：US11618767B2
公开(公告)日：2023-04-04
申请号：US17700824
申请日：2022-03-22
IPC分类号： C07J71/00
摘要： The present invention provides a compound of Formula I: wherein R1 is H, halogen, C1-C3 alkyl, or C1-C3 alkoxy; R2 is H or halogen; and X is O, OCH2, or CH2, or a pharmaceutically acceptable salt thereof, wherein the compound of Formula I, or pharmaceutically acceptable salt thereof is useful for treating autoimmune and inflammatory diseases, such as atopic dermatitis, rheumatoid arthritis, and lupus nephritis.
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