利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

1219 条记录 (耗时 0.03 秒)

    PEPTIDES AND METHODS FOR REDUCING SKIN PIGMENTATION
    3.
    发明公开
    PEPTIDES AND METHODS FOR REDUCING SKIN PIGMENTATION 审中-公开

    公开(公告)号：US20240190917A1

    公开(公告)日：2024-06-13

    申请号：US18473073

    申请日：2023-09-22

    申请人： GLO Pharma, Inc.

    发明人： Robert A. LOVE

    IPC分类号： C07K7/06 ,  C07K1/107

    CPC分类号： C07K7/06 ,  C07K1/1077

    摘要： The present disclosure relates to novel peptide antagonists that inhibit binding of melanocyte stimulating hormone to the melanocortin 1 receptor. The peptide antagonists of the disclosure are useful in cosmetic compositions that prevent or reduce the appearance of skin discoloration caused by pigmentation. The disclosure further relates to cosmetic compositions comprising a peptide antagonist of the disclosure, and methods for their use for preventing or reducing the appearance of skin discoloration in a subject in need thereof.

    ARGININE MODIFICATION AND CONJUGATION METHODS
    6.
    发明公开
    ARGININE MODIFICATION AND CONJUGATION METHODS 审中-公开

    公开(公告)号：US20230331770A1

    公开(公告)日：2023-10-19

    申请号：US18297914

    申请日：2023-04-10

    申请人： Encodia, Inc.

    发明人： Stephen VERESPY, III ,  Duc T. TRAN ,  Samantha BEASLEY

    IPC分类号： C07K1/107

    CPC分类号： C07K1/1077

    摘要： Provided herein are methods for modifying an arginine residue to provide a reactive handle suitable for attaching the arginine residue to a label, linker, or other target molecule. The methods utilize an Arnold Salt to convert the guanidine group of the arginine residue into a formylpyrimidine, and are efficient and very selective. Provided herein are mild reaction conditions for this arginine modification, making it suitable for use with complex biomolecules like proteins. The methods can include one or more additional steps to attach the modified arginine to a linker for further manipulation or for connecting the arginine residue to a target compound. Provided methods are especially useful for covalently linking an arginine-containing peptide to a target molecule such as a polynucleotide.

    Method and sensor for detecting L-arginine
    7.
    发明授权
    Method and sensor for detecting L-arginine 有权

    公开(公告)号：US11761922B2

    公开(公告)日：2023-09-19

    申请号：US16969588

    申请日：2019-12-31

    申请人： CHANGSHA UNIVERSITY OF SCIENCE AND TECHNOLOGY

    发明人： Zhong Cao ,  Ningtao Zhou ,  Li Zhou ,  Qin Zhu ,  Jinglin He ,  Zhongliang Xiao ,  Yumin He ,  Zemeng Feng ,  Yulong Yin

    IPC分类号： G01N27/327 ,  C07K1/107 ,  G01N27/48

    CPC分类号： G01N27/3277 ,  C07K1/1077 ,  G01N27/48

    摘要： A method and a sensor for detecting L-arginine are provided. The method includes synthesizing ferrocene-functionalized hexadecapeptide dithiocyclopentane (FC-P16 Peptide), preparing a polypeptide composite membrane-modified electrode (FC-P16 Peptide/AuE), detecting L-Arg and other steps. The results show that the polypeptide composite membrane-modified electrode (FC-P16 Peptide/AuE) exhibits excellent electrochemical response properties to L-Arg. In 10 mmol/L phosphate-buffered saline (PBS, pH=7.4), the DPV response peak current of the polypeptide composite membrane-modified electrode has an excellent linear relationship with the L-Arg concentration of 1.0×10−13 mol/L to 1.0×10−7 mol/L, with a detection limit of 1.0×10−13 mol/L. With prominent reproducibility, repeatability and selectivity, the modified electrode has potential application in life science and nutritional health.