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公开(公告)号：US07235537B2
公开(公告)日：2007-06-26
申请号：US10652733
申请日：2003-08-29
IPC分类号： A61K31/675 , C07F9/06
CPC分类号： C07D235/06 , C04B35/632 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/04 , C07D413/06 , C07D417/06 , C07D417/12 , C07F9/65068 , C07F9/65586
摘要： Disclosed are compounds of the formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R1, R2, R7, R8, R9 and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.
摘要翻译： 公开了式I化合物及其药学上可接受的盐和前药，其中W，R 1，R 2，R 7，R 7， SUP> 8，R 9和R 10如说明书中所定义。 这些化合物是MEK抑制剂，可用于治疗哺乳动物中的过度增生性疾病，例如癌症和炎症。 还公开了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法，以及含有这些化合物的药物组合物。
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公开(公告)号：US07842816B2
公开(公告)日：2010-11-30
申请号：US11762897
申请日：2007-06-14
IPC分类号： A61K31/4184 , C07D235/06
CPC分类号： C07D235/06 , C04B35/632 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/04 , C07D413/06 , C07D417/06 , C07D417/12 , C07F9/65068 , C07F9/65586
摘要： Disclosed are amino acid prodrugs of compounds of the formula I and pharmaceutically acceptable salts thereof, wherein W, R1, R2, R7, R8, R9 and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative disease in mammals, and pharmaceutical compositions containing such compounds.
摘要翻译： 公开了式I化合物及其药学上可接受的盐的氨基酸前药，其中W，R 1，R 2，R 7，R 8，R 9和R 10如说明书中所定义。 这些化合物是MEK抑制剂，可用于治疗哺乳动物中的过度增生性疾病，例如癌症和炎症。 还公开了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法，以及含有这些化合物的药物组合物。
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3.发明授权Compositions comprising N3 alkylated benzimidazole derivatives as MEK inhibitors and methods of use thereof 有权包含N 3烷基化苯并咪唑衍生物作为MEK抑制剂的组合物及其使用方法公开(公告)号：US08193230B2
公开(公告)日：2012-06-05
申请号：US12824547
申请日：2010-06-28
IPC分类号： A61K31/4184
CPC分类号： C07D235/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/06 , C07D417/12
摘要： Disclosed are pharmaceutical compositions comprising 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxy-ethoxy)-amide, or a pharmaceutically acceptable salt thereof. Also disclosed are methods of using such compositions for inhibiting abnormal cell growth or treating hyperproliferative diseases in mammals.
摘要翻译： 公开了包含6-（4-溴-2-氟苯基氨基）-7-氟-3-甲基-3H-苯并咪唑-5-甲酸（2-羟基 - 乙氧基） - 酰胺或其药学上可接受的盐的药物组合物。 还公开了使用这种组合物抑制哺乳动物异常细胞生长或治疗过度增殖性疾病的方法。
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公开(公告)号：US07973170B2
公开(公告)日：2011-07-05
申请号：US12824497
申请日：2010-06-28
IPC分类号： A61K31/4184 , C07D235/06
CPC分类号： C07D235/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/06 , C07D417/12
摘要： Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R1, R2, R7, R8, R9 and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.
摘要翻译： 公开了式I化合物及其药学上可接受的盐和前药，其中W，R 1，R 2，R 7，R 8，R 9和R 10如说明书中所定义。 这些化合物是MEK抑制剂，可用于治疗哺乳动物中的过度增生性疾病，例如癌症和炎症。 还公开了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法，以及含有这些化合物的药物组合物。
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公开(公告)号：US20080177082A1
公开(公告)日：2008-07-24
申请号：US12050847
申请日：2008-03-18
IPC分类号： C07D235/06
CPC分类号： C07D235/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/06 , C07D417/12
摘要： Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R1, R2, R7, R8, R9 and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.
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6.发明授权Methods of treating a hyperproliferative disorder or inhibiting cell growth in a mammal 有权治疗哺乳动物过度增殖性疾病或抑制细胞生长的方法公开(公告)号：US08513293B2
公开(公告)日：2013-08-20
申请号：US13463487
申请日：2012-05-03
IPC分类号： A61K31/4184 , C07D235/06
CPC分类号： C07D235/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/06 , C07D417/12
摘要： Disclosed are methods for inhibiting abnormal cell growth or treating hyperproliferative diseases in mammals, comprising administering to a mammal in heed thereof a pharmaceutical composition comprising 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxy-ethoxy)-amide, or a pharmaceutically acceptable salt thereof, in combination with an effective amount of an anti-tumor agent or in combination with radiation therapy.
摘要翻译： 公开了抑制哺乳动物异常细胞生长或治疗过度增殖性疾病的方法，包括向哺乳动物施用包含6-（4-溴-2-氟苯基氨基）-7-氟-3-甲基-3H-苯并咪唑的药物组合物 -5-羧酸（2-羟基 - 乙氧基） - 酰胺或其药学上可接受的盐与有效量的抗肿瘤剂组合或与放射治疗组合。
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7.发明申请METHOD OF TREATMENT USING N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS 有权使用N 3烷氧基苯并咪唑衍生物作为MEK抑制剂处理的方法公开(公告)号：US20100267793A1
公开(公告)日：2010-10-21
申请号：US12824521
申请日：2010-06-28
IPC分类号： A61K31/4184 , A61P35/04 , A61P17/00
CPC分类号： C07D235/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/06 , C07D417/12
摘要： Disclosed are methods of treating a hyperproliferative disorder or a disease related to vasculogenesis or angiogenesis in a mammal, comprising administering to said mammal an effective amount of a compound of the formula or a pharmaceutically accepted salt thereof, wherein A, R1, R2, R7, R8, and R9 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals.
摘要翻译： 公开了治疗哺乳动物中过度增殖性疾病或与血管发生或血管发生相关的疾病的方法，包括向所述哺乳动物施用有效量的下式化合物或其药学上可接受的盐，其中A，R 1，R 2，R 7， R8和R9如说明书中所定义。 这些化合物是MEK抑制剂，可用于治疗哺乳动物中的过度增生性疾病，例如癌症和炎症。
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公开(公告)号：US20100267710A1
公开(公告)日：2010-10-21
申请号：US12824497
申请日：2010-06-28
IPC分类号： A61K31/4184 , C07D235/06 , C07D405/12 , C07D405/06 , C07D417/06 , A61K31/427 , C07D413/12 , A61K31/5377 , C07D401/12 , A61K31/454 , C07D403/12 , C07D403/06 , A61K31/496 , C07D401/06 , A61K31/4439 , A61K31/541 , C07D413/06 , A61K31/422 , A61K31/4245 , A61P35/00
CPC分类号： C07D235/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/06 , C07D417/12
摘要： Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R1, R2, R7, R8, R9 and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.
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公开(公告)号：US07425637B2
公开(公告)日：2008-09-16
申请号：US11061336
申请日：2005-02-18
IPC分类号： C07D235/06 , A61K31/4184
CPC分类号： C07D235/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/06 , C07D417/12
摘要： Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R1, R2, R7, R8, R9 and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.
摘要翻译： 公开了式I化合物及其药学上可接受的盐和前药，其中W，R 1，R 2，R 7，R 7， SUP> 8，R 9和R 10如说明书中所定义。 这些化合物是MEK抑制剂，可用于治疗哺乳动物中的过度增生性疾病，例如癌症和炎症。 还公开了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法，以及含有这些化合物的药物组合物。
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公开(公告)号：US08003805B2
公开(公告)日：2011-08-23
申请号：US12824477
申请日：2010-06-28
IPC分类号： A61K31/422 , A61K31/4245 , A61K31/4184 , C07D403/04 , C07D413/04
CPC分类号： C07D235/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/06 , C07D417/12
摘要： Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R1, R2, R7, R8, R9 and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.
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