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    Stabilized aqueous solutions of ergoline compounds
    4.
    发明申请
    Stabilized aqueous solutions of ergoline compounds 审中-公开
    稳定的麦角灵化合物水溶液

    公开(公告)号：US20090239894A1

    公开(公告)日：2009-09-24

    申请号：US12077698

    申请日：2008-03-20

    申请人： Bjorn Schurad ,  Harald Mottl

    发明人： Bjorn Schurad ,  Harald Mottl

    IPC分类号： A61K31/438 ,  C07D221/18 ,  A61P25/28

    CPC分类号： C07D457/12 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/438 ,  A61K47/10

    摘要： The present invention relates to stabilized aqueous solutions of an ergoline compound of formula I or their physiologically tolerable salt or derivative, in which R1 stands for an H atom or a halogen atom and R2 stands for an alkyl group or alkenyl group with 1 to 4 carbons and a single or double bond, also containing 0.05% to 90.00% of at least one oxygen-containing cosolvent. Likewise, the present invention relates to the use of the solutions stabilized according to the present invention to prepare an agent for parenteral treatment of neurodegenerative diseases or brain trauma.

    摘要翻译： 本发明涉及式I的麦角灵化合物或其生理上可耐受的盐或衍生物的稳定化水溶液，其中R1代表H原子或卤素原子，R2代表具有1至4个碳原子的烷基或烯基 还含有0.05％至90.00％的至少一种含氧助溶剂的单键或双键。 同样地，本发明涉及根据本发明稳定化的溶液在制备神经变性疾病或脑外伤肠胃外治疗药物中的应用。

    Treatment with anti-alpha2 integrin antibodies
    5.
    发明授权
    Treatment with anti-alpha2 integrin antibodies 有权
    用抗α2整联蛋白抗体治疗

    公开(公告)号：US08298531B2

    公开(公告)日：2012-10-30

    申请号：US12614178

    申请日：2009-11-06

    申请人： Harald Mottl

    发明人： Harald Mottl

    IPC分类号： A61K39/00 ,  A61K39/395

    CPC分类号： C07K16/2839 ,  A61K2039/505 ,  C07K16/2842 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76

    摘要： The invention relates to treatment of cancer. More specifically the invention relates to methods of treating cancer selected from the group consisting of squamous cell cancer, lung cancer including small-cell lung cancer, non-small cell lung cancer, adenocarcinoma of the lung, and squamous carcinoma of the lung, cancer of the peritoneum, hepatocellular cancer, gastric or stomach cancer including gastrointestinal cancer, pancreatic cancer, glioblastoma, cervical cancer, ovarian cancer, liver cancer, bladder cancer, hepatoma, breast cancer, colon cancer, colorectal cancer, endometrial or uterine carcinoma, salivary gland carcinoma, kidney or renal cancer, liver cancer, prostate cancer, vulval cancer, thyroid cancer, hepatic carcinoma and various types of head and neck cancer, as well as B-cell lymphoma including low grade/follicular non-Hodgkin's lymphoma (NHL); small lymphocytic (SL) NHL; intermediate grade/follicular NHL; intermediate grade diffuse NHL; high grade immunoblastic NHL; high grade lymphoblastic NHL; high grade small non-cleaved cell NHL; bulky disease NHL; mantle cell lymphoma; AIDS-related lymphoma; and Waldenstrom's Macroglobulinemia; chronic lymphocytic leukemia (CLL); acute lymphoblastic leukemia (ALL); Hairy cell leukemia; chronic myeloblastic leukemia; and post-transplant lymphoproliferative disorder (PTLD), as well as abnormal vascular proliferation associated with phakomatoses, edema such as that associated with brain tumors, Meigs' syndrome, melanoma, mesothelioma, multiple myeloma, fibrosarcoma, osteosarcoma and epidermoid carcinoma, by administering antibodies directed to α2β1 integrin.

    摘要翻译： 本发明涉及癌症的治疗。 更具体地，本发明涉及治疗癌症的方法，其选自鳞状细胞癌，包括小细胞肺癌的肺癌，非小细胞肺癌，肺腺癌和肺鳞状细胞癌，癌症 腹膜，肝细胞癌，胃癌或胃癌，包括胃肠癌，胰腺癌，成胶质细胞瘤，子宫颈癌，卵巢癌，肝癌，膀胱癌，肝癌，乳腺癌，结肠癌，结肠直肠癌，子宫内膜或子宫癌，唾液腺癌 ，肾癌，肾癌，肝癌，前列腺癌，外阴癌，甲状腺癌，肝癌和各种类型的头颈癌，以及B细胞淋巴瘤，包括低级/滤泡性非霍奇金淋巴瘤（NHL）; 小淋巴细胞（SL）NHL; 中级/滤泡NHL; 中级弥漫性NHL; 高级免疫母细胞NHL; 高级别淋巴细胞性NHL; 高级小型非裂解细胞NHL; 体积大的NHL; 套细胞淋巴瘤; 艾滋病相关淋巴瘤; 和瓦尔登斯特伦的巨球蛋白血症; 慢性淋巴细胞性白血病（CLL）; 急性淋巴细胞白血病（ALL）; 毛细胞白血病; 慢性成髓细胞白血病; 移植后淋巴增生性疾病（PTLD），以及与phakomatoses相关的异常血管增生，与脑肿瘤，Meigs综合征，黑素瘤，间皮瘤，多发性骨髓瘤，纤维肉瘤，骨肉瘤和表皮样癌相关的水肿，通过​​施用抗体 针对α2和bgr1整合素。

    TREATMENT WITH ANTI-ALPHA2 INTEGRIN ANTIBODIES
    6.
    发明申请
    TREATMENT WITH ANTI-ALPHA2 INTEGRIN ANTIBODIES 有权
    用抗ALPHA2整合抗体治疗

    公开(公告)号：US20100158904A1

    公开(公告)日：2010-06-24

    申请号：US12614178

    申请日：2009-11-06

    申请人： Harald Mottl

    发明人： Harald Mottl

    IPC分类号： A61K39/395 ,  A61P35/00 ,  A61P35/02

    CPC分类号： C07K16/2839 ,  A61K2039/505 ,  C07K16/2842 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76

    摘要： The invention relates to treatment of cancer. More specifically the invention relates to methods of treating cancer selected from the group consisting of squamous cell cancer, lung cancer including small-cell lung cancer, non-small cell lung cancer, adenocarcinoma of the lung, and squamous carcinoma of the lung, cancer of the peritoneum, hepatocellular cancer, gastric or stomach cancer including gastrointestinal cancer, pancreatic cancer, glioblastoma, cervical cancer, ovarian cancer, liver cancer, bladder cancer, hepatoma, breast cancer, colon cancer, colorectal cancer, endometrial or uterine carcinoma, salivary gland carcinoma, kidney or renal cancer, liver cancer, prostate cancer, vulval cancer, thyroid cancer, hepatic carcinoma and various types of head and neck cancer, as well as B-cell lymphoma including low grade/follicular non-Hodgkin's lymphoma (NHL); small lymphocytic (SL) NHL; intermediate grade/follicular NHL; intermediate grade diffuse NHL; high grade immunoblastic NHL; high grade lymphoblastic NHL; high grade small non-cleaved cell NHL; bulky disease NHL; mantle cell lymphoma; AIDS-related lymphoma; and Waldenstrom's Macroglobulinemia; chronic lymphocytic leukemia (CLL); acute lymphoblastic leukemia (ALL); Hairy cell leukemia; chronic myeloblastic leukemia; and post-transplant lymphoproliferative disorder (PTLD), as well as abnormal vascular proliferation associated with phakomatoses, edema such as that associated with brain tumors, Meigs' syndrome, melanoma, mesothelioma, multiple myeloma, fibrosarcoma, osteosarcoma and epidermoid carcinoma, by administering antibodies directed to α2β1 integrin.

    摘要翻译： 本发明涉及癌症的治疗。 更具体地，本发明涉及治疗癌症的方法，其选自鳞状细胞癌，包括小细胞肺癌的肺癌，非小细胞肺癌，肺腺癌和肺鳞状细胞癌，癌症 腹膜，肝细胞癌，胃癌或胃癌，包括胃肠癌，胰腺癌，成胶质细胞瘤，子宫颈癌，卵巢癌，肝癌，膀胱癌，肝癌，乳腺癌，结肠癌，结肠直肠癌，子宫内膜或子宫癌，唾液腺癌 ，肾癌，肾癌，肝癌，前列腺癌，外阴癌，甲状腺癌，肝癌和各种类型的头颈癌，以及B细胞淋巴瘤，包括低级/滤泡性非霍奇金淋巴瘤（NHL）; 小淋巴细胞（SL）NHL; 中级/滤泡NHL; 中级弥漫性NHL; 高级免疫母细胞NHL; 高级别淋巴细胞性NHL; 高级小型非裂解细胞NHL; 体积大的NHL; 套细胞淋巴瘤; 艾滋病相关淋巴瘤; 和瓦尔登斯特伦的巨球蛋白血症; 慢性淋巴细胞性白血病（CLL）; 急性淋巴细胞白血病（ALL）; 毛细胞白血病; 慢性成髓细胞白血病; 移植后淋巴增生性疾病（PTLD），以及与phakomatoses相关的异常血管增生，与脑肿瘤，Meigs综合征，黑素瘤，间皮瘤，多发性骨髓瘤，纤维肉瘤，骨肉瘤和表皮样癌相关的水肿，通过​​施用抗体 针对α2和bgr1整合素。