公开(公告)号：US10899710B2

公开(公告)日：2021-01-26

申请号：US15750805

申请日：2016-08-05

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services ,  Elias Set Jenö Arnér

发明人： Elias Set Jenö Arnér ,  William Chester Stafford ,  Nathan Patrick Coussens ,  Diane Karen Luci ,  David Joseph Maloney ,  Anton Simeonov ,  Ajit Jadhav ,  Thomas S. Dexheimer

IPC分类号： C07D213/71 ,  A61P35/00 ,  A61K45/06

摘要： There is provided compounds of formula (I) or pharmaceutically-acceptable salts thereof, wherein L, R1, R2, R3, R4 and n have meanings provided in the description, which compounds are useful in the treatment of cancers.

公开(公告)号：US11110089B2

公开(公告)日：2021-09-07

申请号：US15750817

申请日：2016-08-05

申请人： Elias Set Jenö Arnér ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Elias Set Jenö Arnér ,  William Chester Stafford ,  Nathan Patrick Coussens ,  Diane Karen Luci ,  David Joseph Maloney ,  Anton Simeonov ,  Ajit Jadhav ,  Thomas S. Dexheimer

IPC分类号： C07D413/06 ,  A61K31/501 ,  A61K45/06

摘要： There is provided compounds of formula (I) or pharmaceutically-acceptable salts thereof, wherein W, X, Y, Z, R1, R2 and R3 have meanings provided in the description, which compounds are useful in the treatment of cancers.

公开(公告)号：US10881653B2

公开(公告)日：2021-01-05

申请号：US15750819

申请日：2016-08-05

申请人： Elias Set Jenö Arnér ,  The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Elias Set Jenö Arnér ,  William Chester Stafford ,  Nathan Patrick Coussens ,  Diane Karen Luci ,  David Joseph Maloney ,  Anton Simeonov ,  Ajit Jadhav ,  Thomas S. Dexheimer

IPC分类号： A61K31/46 ,  A61P35/00 ,  C07D451/00

摘要： There is provided compounds of formula (I), or pharmaceutically-acceptable salts thereof, wherein X, Y, Z, R1 and R2 have meanings provided in the description, which compounds are useful in the treatment of cancers.