公开(公告)号：US20060275873A1

公开(公告)日：2006-12-07

申请号：US10557230

申请日：2004-05-13

申请人： Eliseo Recio Perez ,  Angel Colina Delgado ,  Jesus Fernandez Aparicio ,  Juan Martin Martin

发明人： Eliseo Recio Perez ,  Angel Colina Delgado ,  Jesus Fernandez Aparicio ,  Juan Martin Martin

IPC分类号： C12P19/62 ,  C12N1/21 ,  C07C215/02

CPC分类号： C07C215/18 ,  C12N1/38 ,  C12P1/04 ,  C12P13/001 ,  C12P13/02 ,  C12P17/04 ,  C12P19/626

摘要： The invention provides a compound of the formula (I). Furthermore, the invention provides a process for the production of a compound of formula (I). The present invention also provides a process for the production of natamycin by a Streptomyces strain comprising adding a composition comprising an auto inducer to the fermentation medium. The present invention furthermore provides the use of a compound of formula (I) in the manufacture of a product by fermentation of a Streptomyces strain. The present invention finally discloses a Streptomyces strain that is defective in natamycin production and that is capable of producing a compound of formula (I) wherein both R1 and R2 are hydrogen and a Streptomyces strain that is defective in production of a compound of formula (I) wherein both R1 and R2 are hydrogen and that is capable of producing natamycin in the presence of said compound.

摘要翻译： 本发明提供式（I）化合物。 此外，本发明提供了制备式（I）化合物的方法。 本发明还提供了一种通过链霉菌菌株生产游霉素的方法，包括向发酵培养基中加入包含自动诱导剂的组合物。 本发明还提供式（I）化合物在通过链霉菌菌株发酵制造产物中的用途。 本发明最终公开了一种在游霉素生产中缺陷的链霉菌属菌株，其能够生产式（I）化合物，其中R 1和R 2都是氢 和在其中R 1和R 2都是氢的式（I）化合物的制备中有缺陷的链霉菌属菌株，并且在存在下能够产生那他霉素 的所述化合物。