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公开(公告)号：US09861725B2
公开(公告)日：2018-01-09
申请号：US13319327
申请日：2010-05-24
CPC分类号： A61L27/54 , A61C8/0013 , A61L27/34 , A61L2300/112 , A61L2300/252 , A61L2300/406 , A61L2300/422 , A61L2300/608 , Y10T428/273 , C08L89/00
摘要： A multilayer protein film has a mass of greater than 0.5 μg/cm2 and consists essentially of protein. A drug delivery device comprises the multilayer protein film onto which a pharmaceutically active agent can be loaded. A biomedical implant comprises an implant substrate and the multilayer protein film on at least a portion of the implant substrate surface. A method of making a multilayer protein film having a mass of greater than 0.5 μg/cm2 comprises contacting a substrate with a protein solution at a temperature of from about 30° C. to about 95° C, wherein a multilayer protein film having a mass of greater than 0.5 μg/cm2 is formed on the substrate.
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2.发明申请MULTILAYER PROTEIN FILMS, METHODS OF MAKING, AND DRUG DELIVERY DEVICES AND BIOMEDICAL IMPLANTS EMPLOYING THE FILMS 有权多层蛋白膜，制造方法和药物递送装置和使用膜的生物医用植入物公开(公告)号：US20120114731A1
公开(公告)日：2012-05-10
申请号：US13319327
申请日：2010-05-24
IPC分类号： A61K9/00 , A61K38/18 , A61K31/675 , B05D5/00 , A61P19/08 , B32B9/02 , B05D1/36 , A61K31/663 , A61P31/00
CPC分类号： A61L27/54 , A61C8/0013 , A61L27/34 , A61L2300/112 , A61L2300/252 , A61L2300/406 , A61L2300/422 , A61L2300/608 , Y10T428/273 , C08L89/00
摘要： A multilayer protein film has a mass of greater than 0.5 μg/cm2 and consists essentially of protein. A drug delivery device comprises the multilayer protein film onto which a pharmaceutically active agent can be loaded. A biomedical implant comprises an implant substrate and the multilayer protein film on at least a portion of the implant substrate surface. A method of making a multilayer protein film having a mass of greater than 0.5 μg/cm2 comprises contacting a substrate with a protein solution at a temperature of from about 30° C. to about 95° C., wherein a multilayer protein film having a mass of greater than 0.5 μg/cm2 is formed on the substrate.
摘要翻译： 多层蛋白质膜具有大于0.5μg/ cm 2的质量，并且基本上由蛋白质组成。 药物递送装置包括其上可以加载药物活性剂的多层蛋白质膜。 生物医学植入物包括在植入物衬底表面的至少一部分上的植入物基底和多层蛋白质膜。 制备质量大于0.5μg/ cm 2的多层蛋白质膜的方法包括使底物与蛋白质溶液在约30℃至约95℃的温度下接触，其中多层蛋白质膜具有 在基板上形成大于0.5μg/ cm 2的质量。
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