公开(公告)号：US20090318359A1

公开(公告)日：2009-12-24

申请号：US12487831

申请日：2009-06-19

申请人： Ellen Murphy ,  Emily Mara Braunstein ,  Dorys Garcia-Hand ,  Annaliesa Sybil Anderson ,  Ingrid Lea Dodge ,  Eduardo Arturo Rojas

发明人： Ellen Murphy ,  Emily Mara Braunstein ,  Dorys Garcia-Hand ,  Annaliesa Sybil Anderson ,  Ingrid Lea Dodge ,  Eduardo Arturo Rojas

IPC分类号： A61K38/16 ,  C07K14/00 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10 ,  A61K31/7088 ,  C12P21/00 ,  A61P37/04

CPC分类号： A61K39/092 ,  A61K2039/53 ,  C07K14/315 ,  Y10S435/975

摘要： The present invention relates to polynucleotides encoding Streptococcus group C and G polypeptides and their use in immunogenic compositions. The invention also relates to immunogenic compositions comprising polypeptides encoded by those polynucleotides. In addition, the invention relates to methods of inducing an immune response in mammals against beta hemolytic Streptococcus or beta hemolytic Streptococcus infection using immunogenic compositions of the Streptococcus group C and G polypeptides and polynucleotides.

摘要翻译： 本发明涉及编码链球菌C和G多肽的多核苷酸及其在免疫原性组合物中的用途。 本发明还涉及包含由这些多核苷酸编码的多肽的免疫原性组合物。 此外，本发明涉及使用链球菌C组和G多肽和多核苷酸的免疫原性组合物在哺乳动物中诱导免疫应答的方法，所述免疫应答针对β溶血性链球菌或β-溶血性链球菌感染。

公开(公告)号：US20090318358A1

公开(公告)日：2009-12-24

申请号：US12487765

申请日：2009-06-19

申请人： Ellen Murphy ,  Emily Mara Braunstein ,  Dorys Garcia-Hand ,  Annaliesa Sybil Anderson ,  Ingrid Lea Dodge ,  Eduardo Arturo Rojas

发明人： Ellen Murphy ,  Emily Mara Braunstein ,  Dorys Garcia-Hand ,  Annaliesa Sybil Anderson ,  Ingrid Lea Dodge ,  Eduardo Arturo Rojas

IPC分类号： A61K38/16 ,  C07K14/315 ,  C07H21/04 ,  C12N15/63 ,  C12N1/21 ,  C12N1/19 ,  C12N5/10 ,  C12P21/02 ,  A61P31/00

CPC分类号： A61K39/092 ,  A61K39/00 ,  A61K2039/53 ,  C07K14/315 ,  Y10S435/975

摘要： The present invention relates to compositions and methods of use comprising peptidyl-prolyl isomerase (PPI) polypeptides of group C and G streptococci and polynucleotides encoding same. The invention also relates to immunogenic compositions comprising the PPI polypeptides and polynucleotides, as well as antibodies and antibody fragments that bind the PPI polypeptides. In addition, the invention relates to methods of inducing an immune response in a subject against beta hemolytic streptococci using the immunogenic compositions, as well as conferring passive immunity by administering a therapeutic antibody or antibody fragment.

摘要翻译： 本发明涉及包含C组和G链球菌的肽基 - 脯氨酰异构酶（PPI）多肽和编码其的多核苷酸的组合物和使用方法。 本发明还涉及包含PPI多肽和多核苷酸以及结合PPI多肽的抗体和抗体片段的免疫原性组合物。 此外，本发明涉及使用免疫原性组合物诱导受试者针对β溶血性链球菌的免疫应答的方法，以及通过施用治疗性抗体或抗体片段赋予被动免疫。

公开(公告)号：US08071112B2

公开(公告)日：2011-12-06

申请号：US13028734

申请日：2011-02-16

申请人： Ellen Murphy ,  Emily Mara Braunstein ,  Dorys Garcia-Hand ,  Annaliesa Sybil Anderson ,  Ingrid Lea Dodge ,  Eduardo Arturo Rojas

发明人： Ellen Murphy ,  Emily Mara Braunstein ,  Dorys Garcia-Hand ,  Annaliesa Sybil Anderson ,  Ingrid Lea Dodge ,  Eduardo Arturo Rojas

IPC分类号： A61K39/09

CPC分类号： A61K39/092 ,  A61K2039/53 ,  C07K14/315 ,  Y10S435/975

摘要： The present invention relates to polynucleotides encoding Streptococcus group C and G polypeptides and their use in immunogenic compositions. The invention also relates to immunogenic compositions comprising polypeptides encoded by those polynucleotides. In addition, the invention relates to methods of inducing an immune response in mammals against beta hemolytic Streptococcus or beta hemolytic Streptococcus infection using immunogenic compositions of the Streptococcus group C and G polypeptides and polynucleotides.

摘要翻译： 本发明涉及编码链球菌C和G多肽的多核苷酸及其在免疫原性组合物中的用途。 本发明还涉及包含由这些多核苷酸编码的多肽的免疫原性组合物。 此外，本发明涉及使用链球菌C组和G多肽和多核苷酸的免疫原性组合物在哺乳动物中诱导免疫应答的方法，所述免疫应答针对β溶血性链球菌或β-溶血性链球菌感染。

公开(公告)号：US07914798B2

公开(公告)日：2011-03-29

申请号：US12487831

申请日：2009-06-19

申请人： Ellen Murphy ,  Emily Mara Braunstein ,  Dorys Garcia-Hand ,  Annaliesa Sybil Anderson ,  Ingrid Lea Dodge ,  Eduardo Arturo Rojas

发明人： Ellen Murphy ,  Emily Mara Braunstein ,  Dorys Garcia-Hand ,  Annaliesa Sybil Anderson ,  Ingrid Lea Dodge ,  Eduardo Arturo Rojas

IPC分类号： A61K39/09

CPC分类号： A61K39/092 ,  A61K2039/53 ,  C07K14/315 ,  Y10S435/975

摘要： The present invention relates to polynucleotides encoding Streptococcus group C and G polypeptides and their use in immunogenic compositions. The invention also relates to immunogenic compositions comprising polypeptides encoded by those polynucleotides. In addition, the invention relates to methods of inducing an immune response in mammals against beta hemolytic Streptococcus or beta hemolytic Streptococcus infection using immunogenic compositions of the Streptococcus group C and G polypeptides and polynucleotides.

摘要翻译： 本发明涉及编码链球菌C和G多肽的多核苷酸及其在免疫原性组合物中的用途。 本发明还涉及包含由这些多核苷酸编码的多肽的免疫原性组合物。 此外，本发明涉及使用链球菌C组和G多肽和多核苷酸的免疫原性组合物在哺乳动物中诱导免疫应答的方法，所述免疫应答针对β溶血性链球菌或β-溶血性链球菌感染。

公开(公告)号：US20110171263A1

公开(公告)日：2011-07-14

申请号：US13028734

申请日：2011-02-16

申请人： Ellen Murphy ,  Emily Mara Braunstein ,  Dorys Garcia-Hand ,  Annaliesa Sybil Anderson ,  Ingrid Lea Dodge ,  Eduardo Arturo Rojas

发明人： Ellen Murphy ,  Emily Mara Braunstein ,  Dorys Garcia-Hand ,  Annaliesa Sybil Anderson ,  Ingrid Lea Dodge ,  Eduardo Arturo Rojas

IPC分类号： A61K39/09 ,  C07K14/315 ,  C12N15/63 ,  C07H21/04 ,  C12N1/21 ,  A61P31/04 ,  C12P21/02 ,  C12N5/10 ,  C12N1/19

CPC分类号： A61K39/092 ,  A61K2039/53 ,  C07K14/315 ,  Y10S435/975

摘要： The present invention relates to polynucleotides encoding Streptococcus group C and G polypeptides and their use in immunogenic compositions. The invention also relates to immunogenic compositions comprising polypeptides encoded by those polynucleotides. In addition, the invention relates to methods of inducing an immune response in mammals against beta hemolytic Streptococcus or beta hemolytic Streptococcus infection using immunogenic compositions of the Streptococcus group C and G polypeptides and polynucleotides.

摘要翻译： 本发明涉及编码链球菌C和G多肽的多核苷酸及其在免疫原性组合物中的用途。 本发明还涉及包含由这些多核苷酸编码的多肽的免疫原性组合物。 此外，本发明涉及使用链球菌C组和G多肽和多核苷酸的免疫原性组合物在哺乳动物中诱导免疫应答的方法，所述免疫应答针对β溶血性链球菌或β-溶血性链球菌感染。

公开(公告)号：US07754226B2

公开(公告)日：2010-07-13

申请号：US12487765

申请日：2009-06-19

申请人： Ellen Murphy ,  Emily Mara Braunstein ,  Dorys Garcia-Hand ,  Annaliesa Sybil Anderson ,  Ingrid Lea Dodge ,  Eduardo Arturo Rojas

发明人： Ellen Murphy ,  Emily Mara Braunstein ,  Dorys Garcia-Hand ,  Annaliesa Sybil Anderson ,  Ingrid Lea Dodge ,  Eduardo Arturo Rojas

IPC分类号： A61K39/09

CPC分类号： A61K39/092 ,  A61K39/00 ,  A61K2039/53 ,  C07K14/315 ,  Y10S435/975

摘要： The present invention relates to compositions and methods of use comprising peptidyl-prolyl isomerase (PPI) polypeptides of group C and G streptococci and polynucleotides encoding same. The invention also relates to immunogenic compositions comprising the PPI polypeptides and polynucleotides, as well as antibodies and antibody fragments that bind the PPI polypeptides. In addition, the invention relates to methods of inducing an immune response in a subject against beta hemolytic streptococci using the immunogenic compositions, as well as conferring passive immunity by administering a therapeutic antibody or antibody fragment.

摘要翻译： 本发明涉及包含C组和G链球菌的肽基 - 脯氨酰异构酶（PPI）多肽和编码其的多核苷酸的组合物和使用方法。 本发明还涉及包含PPI多肽和多核苷酸以及结合PPI多肽的抗体和抗体片段的免疫原性组合物。 此外，本发明涉及使用免疫原性组合物诱导受试者针对β溶血性链球菌的免疫应答的方法，以及通过施用治疗性抗体或抗体片段赋予被动免疫。