公开(公告)号：US20240066101A1

公开(公告)日：2024-02-29

申请号：US18486860

申请日：2023-10-13

申请人： Emory University

发明人： Giacomo Waller ,  Yiwen Li ,  Edmund Waller

IPC分类号： A61K38/26 ,  A61K9/00 ,  A61K9/12 ,  A61K47/24 ,  A61K47/69

CPC分类号： A61K38/26 ,  A61K9/0075 ,  A61K9/124 ,  A61K47/24 ,  A61K47/6935

摘要： In certain embodiments, this disclosure relates to VIP and VIP agonists, optionally conjugated to nanoparticles, for use in methods of treating inflammatory T cell-mediated diseases or conditions, e.g., treating or preventing GvHD. In certain embodiments, this disclosure relates to methods of pulmonary administration of VIP and VIP agonists, optionally conjugated to nanoparticles. In certain embodiments, this disclosure contemplates nanoparticles disclosed herein.

公开(公告)号：US11786580B2

公开(公告)日：2023-10-17

申请号：US17050348

申请日：2019-04-23

申请人： Emory University

发明人： Giacomo Waller ,  Yiwen Li ,  Edmund Waller

IPC分类号： A61K38/26 ,  A61K9/00 ,  A61K9/12 ,  A61K47/24 ,  A61K38/22 ,  C07K14/575 ,  A61K47/69

CPC分类号： A61K38/26 ,  A61K9/0075 ,  A61K9/124 ,  A61K47/24 ,  A61K47/6935

摘要： In certain embodiments, this disclosure relates to VIP and VIP agonists, optionally conjugated to nanoparticles, for use in methods of treating inflammatory T cell-mediated diseases or conditions, e.g., treating or preventing GvHD. In certain embodiments, this disclosure relates to methods of pulmonary administration of VIP and VIP agonists, optionally conjugated to nanoparticles. In certain embodiments, this disclosure contemplates nanoparticles disclosed herein.

公开(公告)号：US20210187076A1

公开(公告)日：2021-06-24

申请号：US17050348

申请日：2019-04-23

申请人： Emory University

发明人： Giacomo Waller ,  Yiwen Li ,  Edmund Waller

IPC分类号： A61K38/26 ,  A61K9/12 ,  A61K9/00 ,  A61K47/69 ,  A61K47/24

摘要： In certain embodiments, this disclosure relates to VIP and VIP agonists, optionally conjugated to nanoparticles, for use in methods of treating inflammatory T cell-mediated diseases or conditions, e.g., treating or preventing GvHD. In certain embodiments, this disclosure relates to methods of pulmonary administration of VIP and VIP agonists, optionally conjugated to nanoparticles. In certain embodiments, this disclosure contemplates nanoparticles disclosed herein.

公开(公告)号：US20210046152A1

公开(公告)日：2021-02-18

申请号：US17050376

申请日：2019-04-24

申请人： Emory University ,  Georgia Tech Research Corporation

发明人： Edmund K. Waller ,  Yiwen Li ,  Giacomo Waller ,  Rebecca Pankove ,  Susan Thomas ,  Sruthi Ravindranathan

IPC分类号： A61K38/16 ,  C07K16/28 ,  A61P35/00

摘要： This disclosure relates to methods of treating cancer or viral infections comprising administering an effective amount of a VIP antagonist in combination with an immune check-point inhibitor to a subject in need thereof. In certain embodiments, the immune check-point inhibitor is an anti-PD1 or anti-PDL1 antibody.