公开(公告)号：US12065402B2

公开(公告)日：2024-08-20

申请号：US18200431

申请日：2023-05-22

申请人： Emory University

发明人： Eric Ortlund ,  Suzanne Mays ,  Nathan Jui ,  Autumn Flynn ,  Michael Dugan

IPC分类号： C07C59/54 ,  C07C35/50 ,  C07C39/23 ,  C07C43/23 ,  C07C49/683 ,  C07C49/83 ,  C07C215/70 ,  C07C255/47 ,  C07C271/34 ,  C07C307/02 ,  C07C309/66 ,  C07D249/04 ,  C07F9/09 ,  C07F9/572

CPC分类号： C07C59/54 ,  C07C35/50 ,  C07C39/23 ,  C07C43/23 ,  C07C49/683 ,  C07C49/83 ,  C07C215/70 ,  C07C255/47 ,  C07C271/34 ,  C07C307/02 ,  C07C309/66 ,  C07D249/04 ,  C07F9/091 ,  C07F9/572 ,  C07C2602/22

摘要： This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain embodiments, modulators are derivatives of hexahydropentalene. In certain embodiments, this disclosure relates to methods of treating or preventing cancer, diabetes, or cardiovascular disease by administering an effective amount of a hexahydropentalene derivative disclosed herein.

公开(公告)号：US20210047258A1

公开(公告)日：2021-02-18

申请号：US17071382

申请日：2020-10-15

申请人： Emory University

发明人： Eric Ortlund ,  Suzanne Mays ,  Nathan Jui ,  Autumn Flynn ,  Michael Dugan

IPC分类号： C07C59/54 ,  C07C35/50 ,  C07C39/23 ,  C07C43/23 ,  C07C49/683 ,  C07C49/83 ,  C07C215/70 ,  C07C255/47 ,  C07C271/34 ,  C07C307/02 ,  C07C309/66 ,  C07D249/04 ,  C07F9/09 ,  C07F9/572

摘要： This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain embodiments, modulators are derivatives of hexahydropentalene. In certain embodiments, this disclosure relates to methods of treating or preventing cancer, diabetes, or cardiovascular disease by administering an effective amount of a hexahydropentalene derivative disclosed herein.

公开(公告)号：US20200017433A1

公开(公告)日：2020-01-16

申请号：US16495092

申请日：2018-03-16

申请人： Emory University

发明人： Eric Ortlund ,  Suzanne Mays ,  Nathan Jui ,  Autumn Flynn ,  Michael Dugan

IPC分类号： C07C59/54 ,  C07F9/09 ,  C07F9/572 ,  C07C35/50 ,  C07C39/23 ,  C07C215/70 ,  C07C43/23 ,  C07C49/83 ,  C07C49/683 ,  C07C307/02 ,  C07C271/34 ,  C07C309/66 ,  C07C255/47 ,  C07D249/04

摘要： This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain embodiments, modulators are derivatives of hexahydropentalene. In certain embodiments, this disclosure relates to methods of treating or preventing cancer, diabetes, or cardiovascular disease by administering an effective amount of a hexahydropentalene derivative disclosed herein.

公开(公告)号：US20230295070A1

公开(公告)日：2023-09-21

申请号：US18200431

申请日：2023-05-22

申请人： Emory University

发明人： Eric Ortlund ,  Suzanne Mays ,  Nathan Jui ,  Autumn Flynn ,  Michael Dugan

IPC分类号： C07C59/54 ,  C07C35/50 ,  C07C39/23 ,  C07C43/23 ,  C07C49/683 ,  C07C49/83 ,  C07C215/70 ,  C07C255/47 ,  C07C271/34 ,  C07C307/02 ,  C07C309/66 ,  C07D249/04 ,  C07F9/09 ,  C07F9/572

CPC分类号： C07C59/54 ,  C07C35/50 ,  C07C39/23 ,  C07C43/23 ,  C07C49/683 ,  C07C49/83 ,  C07C215/70 ,  C07C255/47 ,  C07C271/34 ,  C07C307/02 ,  C07C309/66 ,  C07D249/04 ,  C07F9/091 ,  C07F9/572 ,  C07C2602/22

摘要： This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain embodiments, modulators are derivatives of hexahydropentalene. In certain embodiments, this disclosure relates to methods of treating or preventing cancer, diabetes, or cardiovascular disease by administering an effective amount of a hexahydropentalene derivative disclosed herein.

公开(公告)号：US11691939B2

公开(公告)日：2023-07-04

申请号：US17071382

申请日：2020-10-15

申请人： Emory University

发明人： Eric Ortlund ,  Suzanne Mays ,  Nathan Jui ,  Autumn Flynn ,  Michael Dugan

IPC分类号： C07C59/54 ,  C07C35/50 ,  C07C39/23 ,  C07C43/23 ,  C07C49/683 ,  C07C49/83 ,  C07C215/70 ,  C07C255/47 ,  C07C271/34 ,  C07C307/02 ,  C07C309/66 ,  C07D249/04 ,  C07F9/09 ,  C07F9/572

CPC分类号： C07C59/54 ,  C07C35/50 ,  C07C39/23 ,  C07C43/23 ,  C07C49/683 ,  C07C49/83 ,  C07C215/70 ,  C07C255/47 ,  C07C271/34 ,  C07C307/02 ,  C07C309/66 ,  C07D249/04 ,  C07F9/091 ,  C07F9/572 ,  C07C2602/22

摘要： This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain embodiments, modulators are derivatives of hexahydropentalene. In certain embodiments, this disclosure relates to methods of treating or preventing cancer, diabetes, or cardiovascular disease by administering an effective amount of a hexahydropentalene derivative disclosed herein.