公开(公告)号：US11905232B2

公开(公告)日：2024-02-20

申请号：US17429183

申请日：2020-02-10

申请人： Nogra Pharma Limited

发明人： Salvatore Demartis ,  Francesca Viti ,  Marie McNulty

IPC分类号： C07C231/10 ,  C07C201/12 ,  C07C205/56 ,  C07C231/18 ,  C07C233/54 ,  C07C231/02 ,  C07C227/04 ,  C07C303/28

CPC分类号： C07C231/10 ,  C07C201/12 ,  C07C205/56 ,  C07C227/04 ,  C07C231/02 ,  C07C231/18 ,  C07C233/54 ,  C07C303/28 ,  C07C201/12 ,  C07C205/56 ,  C07C303/28 ,  C07C309/66 ,  C07C227/04 ,  C07C229/42 ,  C07C231/02 ,  C07C233/54

摘要： The disclosure provides a process for the preparation of 3-(4′-aminophenyl)-2-methoxypropionic acid, and analogs and intermediates thereof, contemplated to be capable of modulating the activity of receptors, e.g., PPARs receptors.

公开(公告)号：US20230295070A1

公开(公告)日：2023-09-21

申请号：US18200431

申请日：2023-05-22

申请人： Emory University

发明人： Eric Ortlund ,  Suzanne Mays ,  Nathan Jui ,  Autumn Flynn ,  Michael Dugan

IPC分类号： C07C59/54 ,  C07C35/50 ,  C07C39/23 ,  C07C43/23 ,  C07C49/683 ,  C07C49/83 ,  C07C215/70 ,  C07C255/47 ,  C07C271/34 ,  C07C307/02 ,  C07C309/66 ,  C07D249/04 ,  C07F9/09 ,  C07F9/572

CPC分类号： C07C59/54 ,  C07C35/50 ,  C07C39/23 ,  C07C43/23 ,  C07C49/683 ,  C07C49/83 ,  C07C215/70 ,  C07C255/47 ,  C07C271/34 ,  C07C307/02 ,  C07C309/66 ,  C07D249/04 ,  C07F9/091 ,  C07F9/572 ,  C07C2602/22

摘要： This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain embodiments, modulators are derivatives of hexahydropentalene. In certain embodiments, this disclosure relates to methods of treating or preventing cancer, diabetes, or cardiovascular disease by administering an effective amount of a hexahydropentalene derivative disclosed herein.

公开(公告)号：US11691939B2

公开(公告)日：2023-07-04

申请号：US17071382

申请日：2020-10-15

申请人： Emory University

发明人： Eric Ortlund ,  Suzanne Mays ,  Nathan Jui ,  Autumn Flynn ,  Michael Dugan

IPC分类号： C07C59/54 ,  C07C35/50 ,  C07C39/23 ,  C07C43/23 ,  C07C49/683 ,  C07C49/83 ,  C07C215/70 ,  C07C255/47 ,  C07C271/34 ,  C07C307/02 ,  C07C309/66 ,  C07D249/04 ,  C07F9/09 ,  C07F9/572

CPC分类号： C07C59/54 ,  C07C35/50 ,  C07C39/23 ,  C07C43/23 ,  C07C49/683 ,  C07C49/83 ,  C07C215/70 ,  C07C255/47 ,  C07C271/34 ,  C07C307/02 ,  C07C309/66 ,  C07D249/04 ,  C07F9/091 ,  C07F9/572 ,  C07C2602/22

摘要： This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain embodiments, modulators are derivatives of hexahydropentalene. In certain embodiments, this disclosure relates to methods of treating or preventing cancer, diabetes, or cardiovascular disease by administering an effective amount of a hexahydropentalene derivative disclosed herein.

公开(公告)号：US20180355386A1

公开(公告)日：2018-12-13

申请号：US16107349

申请日：2018-08-21

申请人： Shin-Etsu Chemical Co., Ltd.

发明人： Miyoshi Yamashita ,  Takeshi Kinsho

IPC分类号： C12P7/62 ,  C07C69/78 ,  C07C67/08 ,  C07C303/28 ,  C07C29/80 ,  C07C67/10 ,  C07C67/54 ,  C07C29/09 ,  C07C309/66 ,  C07C309/73 ,  C07C33/025 ,  C07C69/145

CPC分类号： C12P7/62 ,  C07B2200/07 ,  C07B2200/09 ,  C07C29/095 ,  C07C29/80 ,  C07C67/08 ,  C07C67/10 ,  C07C67/54 ,  C07C69/78 ,  C07C303/28 ,  C07C309/66 ,  C07C309/73 ,  C07C33/025 ,  C07C69/145

摘要： Provided are methods including a method for industrially producing (2S,12Z)-2-acetoxy-12-heptadecene, which is, for example, a sex pheromone of pistachio twig borer. The methods can include a production method comprising a step of reacting racemic (2RS,12Z)-2-hydroxy-12-heptadecene with vinyl benzoate in the presence of a lipase to obtain a mixture of optically active (2R,12Z)-2-benzoyloxy-12-heptadecene of Formula (R,Z-2) and optically active (2S,12Z)-2-hydroxy-12-heptadecene of Formula (S,Z-1), a step of heating the mixture to distill out the optically active (2S,12Z)-2-hydroxy-12-heptadecene (S,Z-1), and a step of acetylating the optically active (2S,12Z)-2-hydroxy-12-heptadecene (S,Z-1) to obtain optically active (2S,12Z)-2-acetoxy-12-heptadecene of Formula (S,Z-3).

公开(公告)号：US20180222936A1

公开(公告)日：2018-08-09

申请号：US15941494

申请日：2018-03-30

申请人： WAVE LIFE SCIENCES LTD.

发明人： Gregory L. Verdine ,  Meena ,  Naoki Iwamoto ,  David Charles Donnell Butler

IPC分类号： C07H21/04 ,  C07H13/04 ,  A61K31/66 ,  C07C309/66 ,  A61K31/70 ,  C07D295/108

CPC分类号： C07H21/04 ,  A61K31/66 ,  A61K31/70 ,  C07C309/66 ,  C07D295/108 ,  C07H13/04

摘要： Described herein are methods for the synthesis of derivatives of thiosulfonate reagents. Said reagents have utility for the synthesis of phosphorothiotriesters from H-phosphonates in a stereospecific fashion.

公开(公告)号：US20180088362A1

公开(公告)日：2018-03-29

申请号：US15716715

申请日：2017-09-27

申请人： SAMSUNG ELECTRONICS CO., LTD.

发明人： Young Soo KIM ,  Hyun Ho LEE ,  Tae Soon PARK

IPC分类号： G02F1/061 ,  C07D327/04 ,  C07C309/66

CPC分类号： G02F1/061 ,  B60R1/088 ,  C07C309/66 ,  C07D327/04 ,  G02F1/0102 ,  G02F1/0121 ,  G02F1/1506 ,  G02F1/1525 ,  G02F1/157 ,  G02F1/163

摘要： An electrochemical mirror includes a first transparent electrode; a second transparent electrode disposed to be spaced apart from the first transparent electrode; and an electrolyte layer disposed between the first transparent electrode and the second transparent electrode and including an electrolyte solution, the electrolyte solution including a compound having a sulfonate functional group or a derivative compound having the same, as an electrolyte solution additive.

公开(公告)号：US09902675B2

公开(公告)日：2018-02-27

申请号：US14780760

申请日：2014-03-28

申请人： TOKYO OHKA KOGYO CO., LTD. ,  DAICEL CORPORATION

发明人： Dai Shiota ,  Kunihiro Noda ,  Hiroki Chisaka ,  Yasuyuki Akai ,  Ichiro Takase ,  Yoshiya Narasaki ,  Daisuke Tanida ,  Kyuhei Kitao

IPC分类号： C07C57/50 ,  C07C69/54 ,  G03F7/027 ,  C07C43/215 ,  C07C43/23 ,  C07C309/66 ,  C07C41/22 ,  C07C41/24 ,  C07C43/225 ,  C07C67/14 ,  C07C303/30

CPC分类号： C07C43/215 ,  C07C41/22 ,  C07C41/24 ,  C07C43/225 ,  C07C43/23 ,  C07C57/50 ,  C07C67/14 ,  C07C69/54 ,  C07C303/30 ,  C07C309/66 ,  C07C2603/18 ,  G03F7/027

摘要： A novel vinyl-group-containing fluorene compound and a method for producing the same, a polymerizable monomer and cross-linking agent including this compound, a leaving-group-containing fluorene compound, a monovinyl-group-containing fluorene compound, and methods for producing the same. This vinyl-group-containing fluorene compound is represented by formula (1). In the formula, W1 and W2 represent a group represented by formula (2), a group represented by formula (4), a hydroxyl group, or a (meth)acryloyloxy group, R3a and R3b represent a cyano group, a halogen atom, or a monovalent hydrocarbon, and n1 and n2 are integers of 0-4. In formulas (2) and (4), a ring (Z) is an aromatic hydrocarbon ring, X is a single bond or a group represented by —S—, R1 is a single bond or a C1-4 alkylene group, R2 is a specific substituent group such as a monovalent hydrocarbon, and m is an integer of 0 or greater.

公开(公告)号：US20180050973A1

公开(公告)日：2018-02-22

申请号：US15800902

申请日：2017-11-01

申请人： TOKYO OHKA KOGYO CO., LTD. ,  DAICEL CORPORATION

发明人： Dai SHIOTA ,  Kunihiro NODA ,  Hiroki CHISAKA ,  Yasuyuki AKAI ,  Ichiro TAKASE ,  Yoshiya NARASAKI ,  Daisuke TANIDA ,  Kyuhei KITAO

IPC分类号： C07C43/215 ,  C07C303/30 ,  C07C57/50 ,  C07C67/14 ,  C07C41/22 ,  C07C69/54 ,  C07C43/225 ,  G03F7/027 ,  C07C309/66 ,  C07C43/23 ,  C07C41/24

CPC分类号： C07C43/215 ,  C07C41/22 ,  C07C41/24 ,  C07C43/225 ,  C07C43/23 ,  C07C57/50 ,  C07C67/14 ,  C07C69/54 ,  C07C303/30 ,  C07C309/66 ,  C07C2603/18 ,  G03F7/027

摘要： A novel vinyl-group-containing fluorene compound and a method for producing the same, a polymerizable monomer and cross-linking agent including the compound, a leaving-group-containing fluorene compound, a monovinyl-group-containing fluorene compound, and methods for producing the same. The vinyl-group-containing fluorene compound is represented by formula (1) in which W1 and W2 represent a group represented by formula (2), a group represented by formula (4), a hydroxyl group, or a (meth)acryloyloxy group, R3a and R3b represent a cyano group, a halogen atom, or a monovalent hydrocarbon, and n1 and n2 are integers of 0-4. In formulas (2) and (4), (Z) is an aromatic hydrocarbon ring, X is a single bond or a group represented by —S—, R1 is a single bond or a C1-4 alkylene group, R2 is a substituent such as a monovalent hydrocarbon, and m is an integer of 0 or more).

公开(公告)号：US20180026201A1

公开(公告)日：2018-01-25

申请号：US15541524

申请日：2016-01-05

申请人： BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE

发明人： NOUREEN SIRAJ ,  ISIAH MANUEL WARNER ,  THENAHANDI PRASANTHI DEEPTHIKA DE SILVA

IPC分类号： H01L51/00 ,  C07C309/66 ,  C07D403/14 ,  C09K11/06 ,  C07C303/40 ,  C07C303/30 ,  C07D403/04 ,  C07C311/48

CPC分类号： H01L51/0072 ,  C07C303/30 ,  C07C303/40 ,  C07C309/66 ,  C07C311/48 ,  C07D403/04 ,  C07D403/14 ,  C09K11/06 ,  C09K2211/1018 ,  C09K2211/1074 ,  H01G9/2013 ,  H01L51/0025 ,  H01L51/0067 ,  H01L51/5032 ,  H01L51/5072 ,  H01L51/5206 ,  H01L51/5221 ,  H01L51/56 ,  Y02E10/542 ,  Y02P70/521

摘要： Various examples are provided for carbazole-based GUMBOS (group of uniform materials based on organic salts), and its application in organic light emitting diodes (OLEDs). In one example, a composition includes a solid phase carbazole-based GUMBOS (group of uniform materials based on organic salts) comprising a counterion such as, e.g., trifluoromethanesulfonate ([Otf]), bis-(trifluoromethanesulfonyl)imide ([NTf2]), bis-(pentafluoroethylsulfonyl)imide ([BETI]), tetrafluoroborate (BF4), hexa-fluorophosphate (PF6), and/or thiocyanate (SCN). The carbazole-based GUMBOS can include carbazoleimidazole-based GUMBOS or 3,6-diBDC carbazolium-based GUMBOS. In another example, a method includes preparing a biphasic solution; separating a layer of DCM from the biphasic solution after stirring; washing the DCM with water to remove byproducts; and evaporating the DCM to form a solid phase carbazoleimidazole-based GUMBOS. Preparing the biphasic solution can include carbazoleimidazolium iodide (CM) dissolved in dichloromethane (DCM) and a dissolved salt including a sodium salt or a lithium salt.

公开(公告)号：US20180009745A1

公开(公告)日：2018-01-11

申请号：US15545435

申请日：2016-01-25

申请人： Avexxin AS

发明人： Marcel Sanderberg ,  Inger-Reidun Aukrust

IPC分类号： C07C319/14 ,  C07C319/28 ,  C07C319/02 ,  C07C327/22 ,  C07C303/28

CPC分类号： C07C319/14 ,  C07C303/28 ,  C07C319/02 ,  C07C319/28 ,  C07C327/22 ,  C07C309/66 ,  C07C323/14 ,  C07C321/08

摘要： A process for the preparation of a polyunsaturated thiol comprising: (1) reacting a polyunsaturated alcohol in the presence of a compound of formula R2—SO2Hal wherein R2 is a C1-20 hydrocarbyl group, such an C1-10 alkyl group, to form a polyunsaturated sulphonyl ester; (2) converting the polyunsaturated sulphonyl ester to a polyunsaturated thioester by reacting with an anion of formula −SC(═O)R4 wherein R4 is a C1-20 hydrocarbyl group; (3) converting the polyunsaturated thioester to form a polyunsaturated thiol optionally in the presence of an antioxidant, e.g. using a metal carbonate. (4) reacting said polyunsaturated thiol with a compound (LG)R3COX wherein X is an electron withdrawing group and R3 is an alkylene group carrying a leaving group (LG), such as LG-CH2— forming where X is an electron withdrawing group and LG is a leaving group; optionally in the presence of an antioxidant, so as to form a polyunsaturated ketone compound.