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1.发明申请BACTERIALLY-DERIVED, INTACT MINICELLS THAT ENCOMPASS PLASMID-FREE FUNCTIONAL NUCLEIC ACID FOR IN VIVO DELIVERY TO MAMMALIAN CELLS 审中-公开特异性衍生的，致命的小细胞，其具有免疫功能的核酸，用于向哺乳动物细胞递送公开(公告)号：US20160051687A1
公开(公告)日：2016-02-25
申请号：US14744848
申请日：2015-06-19
IPC分类号： A61K47/46 , A61K31/713 , C07K16/40 , A61K47/48 , C07K16/12 , C12N15/113 , A61K39/40
CPC分类号： A61K9/5068 , A61K31/4745 , A61K31/713 , A61K39/39558 , A61K39/40 , A61K47/46 , A61K47/48776 , A61K47/6901 , A61K47/6923 , A61K48/0008 , C07K16/1235 , C07K16/2863 , C07K16/40 , C07K2317/31 , C12N15/111 , C12N15/113 , C12N15/1135 , C12N15/1137 , C12N15/1138 , C12N2310/11 , C12N2310/111 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12N2320/32 , Y02A50/473
摘要： Intact, bacterially-derived minicells can safely introduce therapeutically effective amounts of plasmid-free functional nucleic acid to target mammalian cells. To this end, functional nucleic acid can be packaged into intact minicells directly, without resort to expression constructs, the expression machinery of the host cell, harsh chemicals or electroporation.
摘要翻译： 完整的，细菌来源的小细胞可以安全地将治疗有效量的无质粒功能性核酸引入目标哺乳动物细胞。 为此，可以将功能性核酸直接包装到完整的微细胞中，而无需使用表达构建体，宿主细胞的表达机制，恶劣的化学物质或电穿孔。
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2.发明申请公开(公告)号：US20170258734A1
公开(公告)日：2017-09-14
申请号：US15604555
申请日：2017-05-24
IPC分类号： A61K9/50 , C07K16/28 , C12N15/11 , C12N15/113 , A61K31/713 , A61K48/00 , A61K31/4745 , A61K39/395 , C07K16/40 , A61K39/40 , C07K16/12 , A61K47/46
CPC分类号： A61K9/5068 , A61K31/4745 , A61K31/713 , A61K39/39558 , A61K39/40 , A61K47/46 , A61K47/6901 , A61K47/6923 , A61K48/0008 , C07K16/1235 , C07K16/2863 , C07K16/40 , C07K2317/31 , C12N15/111 , C12N15/113 , C12N15/1135 , C12N15/1137 , C12N15/1138 , C12N2310/11 , C12N2310/111 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12N2320/32 , Y02A50/473
摘要： Intact, bacterially-derived minicells can safely introduce therapeutically effective amounts of plasmid-free functional nucleic acid to target mammalian cells. To this end, functional nucleic acid can be packaged into intact minicells directly, without resort to expression constructs, the expression machinery of the host cell, harsh chemicals or electroporation.
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