公开(公告)号：US12104175B2

公开(公告)日：2024-10-01

申请号：US16687426

申请日：2019-11-18

申请人： Encoded Therapeutics, Inc.

发明人： Kartik Ramamoorthi ,  Stephanie Tagliatela ,  Anne Tanenhaus ,  Andrew Young ,  Szu-Ying Chen ,  Chi Zhang ,  Stephanie Martin ,  David Oberkofler

IPC分类号： C12N7/00 ,  A61K48/00 ,  A61P1/16 ,  A61P7/02 ,  C12N15/86

CPC分类号： C12N7/00 ,  A61K48/005 ,  A61P1/16 ,  A61P7/02 ,  C12N15/86 ,  C12N2750/14121 ,  C12N2750/14132 ,  C12N2750/14142 ,  C12N2750/14143

摘要： Provided herein are compositions and methods for driving high expression of a transgene. Compositions and methods for driving high expression of a transgene comprising one or more human-derived regulatory elements, which, when operably linked to a transgene, can result in high expression of the transgene in one or more cell types or tissues.