公开(公告)号：US20240151584A1

公开(公告)日：2024-05-09

申请号：US18053246

申请日：2022-11-07

Applicant: Endress+Hauser Optical Analysis, Inc.

Inventor： Nicholas Skriba ,  James Tedesco ,  Joseph Slater

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/4412 ,  G01N21/65 ,  G01N2021/0346

Abstract: Flowcells and Raman analysis systems provide improved signal collection dynamics through increased solid-angle geometries and improved numerical aperture for near-diffraction-limited performance. A combined excitation/collection beam passes through a first optical material, a sample conduit and a second optical material. A concave reflective aspheric surface focuses and re-collimates the combined beam to and from a region of the sample within the conduit. The optical materials may comprise separate windows or may integrally form sidewalls the conduit. The reflective surface may be spaced apart from the second window or may be integrally formed with the second optical material. The focused region in the sample may approximate a point or a line, and at least a portion of the interior wall of the conduit may be reflective, causing the combined beam to pass through the sample region more than once to enhance collection efficiency.

公开(公告)号：US20250052614A1

公开(公告)日：2025-02-13

申请号：US18480812

申请日：2023-10-04

Applicant: Endress+Hauser Optical Analysis, Inc.

Inventor： Joseph Slater

IPC: G01J3/44

Abstract: A reference material for and a method of calibrating at least one Raman spectrometer are disclosed. The reference material includes quantum dots distributed in a transparent condensed phase material such that light emitted by the reference material in response to receiving excitation light having an excitation wavelength provided by the Raman spectrometer(s) has a predetermined spectral intensity distribution in a spectral measurement range of the Raman spectrometer(s). The method includes designing, manufacturing and providing the reference material, determining an emission spectrum of the reference material, and calibrating each Raman spectrometer by determining a reference spectrum of the reference material and by adjusting a determination of spectral intensity values of intensity spectra performed by the Raman spectrometer based on the reference spectrum and the emission spectrum of the reference material.