公开(公告)号：US12019272B2

公开(公告)日：2024-06-25

申请号：US17713770

申请日：2022-04-05

Applicant: Oak Analytics Inc.

Inventor： Ruibo Wang ,  James F. Gass

IPC: G02B6/14 ,  G01J3/04 ,  G01J3/44

CPC classification number: G02B6/14 ,  G01J3/04 ,  G01J3/4412

Abstract: One embodiment provides an optical spectrometer. The optical spectrometer can include a lens-and-filter system configured to collect light scattered from a sample, a spot converter configured to convert a substantially circular beam outputted from the lens-and-filter system into a substantially rectangular beam, and a slit comprising a rectangular aperture to allow a predetermined portion of the substantially rectangular beam to enter the rectangular aperture while blocking noise. The slit can further include at least one microelectromechanical systems (MEMS)-based movable structure configured to adjust a width of the rectangular aperture.

公开(公告)号：US11994533B2

公开(公告)日：2024-05-28

申请号：US17105475

申请日：2020-11-25

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Rafael Piestun ,  Simon Labouesse ,  Markus B. Raschke ,  Eric Muller ,  Samuel Johnson

IPC: G01J3/02 ,  G01J3/10 ,  G01J3/28 ,  G01J3/44 ,  G01J3/45 ,  G01Q10/06 ,  G01Q30/04 ,  G01Q60/06 ,  G01Q60/22

CPC classification number: G01Q60/22 ,  G01J3/0208 ,  G01J3/10 ,  G01J3/2846 ,  G01J3/4412 ,  G01J3/45 ,  G01Q10/06 ,  G01Q30/04 ,  G01Q60/06

Abstract: Infrared (IR) vibrational scattering scanning near-field optical microscopy (s-SNOM) has advanced to become a powerful nanoimaging and spectroscopy technique with applications ranging from biological to quantum materials. However, full spatiospectral s-SNOM continues to be challenged by long measurement times and drift during the acquisition of large associated datasets. Various embodiments provide for a novel approach of computational spatiospectral s-SNOM by transforming the basis from the stationary frame into the rotating frame of the IR carrier frequency. Some embodiments see acceleration of IR s-SNOM data collection by a factor of 10 or more in combination with prior knowledge of the electronic or vibrational resonances to be probed, the IR source excitation spectrum, and other general sample characteristics.

公开(公告)号：US11965781B2

公开(公告)日：2024-04-23

申请号：US18312730

申请日：2023-05-05

Applicant: Sanguis Corporation

Inventor： Jeffrey Owen Katz

IPC: G01J3/44 ,  G01J3/02 ,  G01J3/06 ,  G01N21/65 ,  G01N33/49

CPC classification number: G01J3/4412 ,  G01J3/0202 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0275 ,  G01J3/06 ,  G01N21/65 ,  G01N33/492 ,  G01J2003/062 ,  G01J2003/064

Abstract: A system for non-invasively interrogating an in vivo sample for measurement of analytes comprises a pulse sensor coupled to the in vivo sample for detect a blood pulse of the sample and for generating a corresponding pulse signal, a laser generator for generating a laser radiation having a wavelength, power and diameter, the laser radiation being directed toward the sample to elicit Raman signals, a laser controller adapted to activate the laser generator, a spectrometer situated to receive the Raman signals and to generate analyte spectral data; and a computing device coupled to the pulse sensor, laser controller and spectrometer which is adapted to correlate the spectral data with the pulse signal based on timing data received from the laser controller in order to isolate spectral components from analytes within the blood of the sample from spectral components from analytes arising from non-blood components of the sample.

公开(公告)号：US11913836B2

公开(公告)日：2024-02-27

申请号：US17488493

申请日：2021-09-29

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Koyo Watanabe ,  Hisanari Takahashi ,  Kyohei Shigematsu ,  Takashi Inoue

IPC: G01J3/44 ,  G01J3/02 ,  G01J3/28

CPC classification number: G01J3/4412 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/2823

Abstract: A dispersion measurement apparatus includes a pulse forming unit, a correlation optical system, a beam splitter, an operation unit, an imaging unit, a spatial filter unit, and a photodetector. The pulse forming unit forms a light pulse train including light pulses having time differences and different center wavelengths. The beam splitter branches the light pulse train passed through a measurement object. The imaging unit disperses one light pulse train and images each light pulse. The spatial filter unit extracts light of a partial region of the other light pulse train. The correlation optical system outputs correlation light including a cross-correlation or an autocorrelation of the extracted light. The photodetector detects a temporal waveform of the correlation light. The operation unit estimates a wavelength dispersion amount in the measurement object based on a feature value of the temporal waveform.

公开(公告)号：US20240060900A1

公开(公告)日：2024-02-22

申请号：US18269558

申请日：2021-12-22

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Siva UMAPATHY ,  Sanchita SIL ,  Dipak KUMBHAR ,  R Vishnu KUMAR

IPC: G01N21/65 ,  G01J3/44

CPC classification number: G01N21/65 ,  G01J3/4412 ,  G01N2201/06113 ,  G01N2201/0631

Abstract: The method includes homogenizing a monochromatic coherent light source, irradiating the sample at plurality of points along all planes with the homogenized monochromatic light, collecting the molecular scattered light from all angles and planes to obtain a plurality of profile, resolving the plurality of profiles to obtain a molecular intensity maps, and reconstituting the intensity maps to obtain a three dimensional image of the sample. The system described is capable of obtaining molecular specific 3D morphology and profile of samples. The system described is capable of differentiating different chemicals or sample distribution throughout the 3D volume.

公开(公告)号：US20230358609A1

公开(公告)日：2023-11-09

申请号：US18218651

申请日：2023-07-06

Applicant: MetGen, Incorporated

Inventor： Richard D. Shunnarah ,  Hugh F. Garvey ,  Lenzi J. Williams ,  Devon Fish

IPC: G01J3/02 ,  G01N33/52 ,  G01N21/65 ,  G01J3/44 ,  G01N33/68

CPC classification number: G01J3/0272 ,  G01N33/523 ,  G01J3/0256 ,  G01N21/658 ,  G01J3/4412 ,  G01N33/6812

Abstract: A gold nanoporous anodic aluminum oxide (NAAO) substrate used in coordination with a handheld Surface-Enhanced Raman Spectroscopy (SERS) device for detecting phenylalanine (Phe) in a sample collected from a subject, the gold NAAO substrate comprising a multilayered nanoporous aluminum layer; and a gold layer disposed on top of the multilayered nanoporous aluminum layer. The gold layer comprises gold nanoparticles.

公开(公告)号：US20230349763A1

公开(公告)日：2023-11-02

申请号：US17902578

申请日：2022-09-02

Applicant: National Tsing Hua University

Inventor： TaJen YEN ,  Wei-Cheng LIN ,  Fang Jing LEE

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/4412 ,  G01N21/658

Abstract: A Raman detecting chip, a method of fabricating the same and a Raman spectroscopy detecting system using such Raman detecting chip are disclosed. The Raman detecting chip according to the invention includes a substrate, a plurality of nanowires and a plurality of three-dimensional dendritic metal nanostructures. The substrate has a recess. The recess has a circular opening and a circular bottom surface. The plurality of nanowires are formed on the circular bottom surface and protrude upwards. The plurality of three-dimensional dendritic metal nanostructures are formed on a plurality of tops of the plurality of nanowires and extend beyond the circular opening.

公开(公告)号：US11766216B2

公开(公告)日：2023-09-26

申请号：US17757130

申请日：2020-12-11

Applicant: ROCKLEY PHOTONICS LIMITED

Inventor： Aaron John Zilkie ,  Hooman Abediasl ,  Cristiano Dalvi ,  Jeffrey Driscoll ,  Alexander Gondarenko ,  Richard Grote ,  Haydn Frederick Jones ,  Sean Merritt ,  Roozbeh Parsa ,  Philip Perea ,  Andrew George Rickman ,  Adam Scofield ,  Goumin Yu

IPC: A61B5/00 ,  A61B5/01 ,  A61B5/024 ,  A61B5/145 ,  A61B5/1455 ,  G01J3/44 ,  G02B6/12

CPC classification number: A61B5/6801 ,  A61B5/0075 ,  A61B5/01 ,  A61B5/02427 ,  A61B5/14532 ,  A61B5/14552 ,  A61B5/683 ,  G01J3/4412 ,  G02B6/12004 ,  G02B6/12007 ,  A61B2562/0238 ,  G02B2006/12061 ,  G02B2006/12121 ,  G02B2006/12142

Abstract: An optical sensing module suitable for wearable devices, the optical sensing module comprising: a silicon or silicon nitride transmitter photonic integrated circuit (PIC), the transmitter PIC comprising: a plurality of lasers, each laser of the plurality of lasers operating at a wavelength that is different from the wavelength of the others; an optical manipulation region, the optical manipulation region comprising one or more of: an optical modulator, optical multiplexer (MUX); and additional optical manipulation elements; and one or more optical outputs for light originating from the plurality of lasers.

公开(公告)号：US11740183B2

公开(公告)日：2023-08-29

申请号：US17759031

申请日：2020-11-24

Applicant: NOVA LTD.

Inventor： Elad Schleifer ,  Yonatan Oren ,  Amir Shayari ,  Eyal Hollander ,  Valery Deich ,  Shimon Yalov ,  Gilad Barak

IPC: G01J3/44 ,  G01N21/65 ,  G01J3/02

CPC classification number: G01N21/65 ,  G01J3/0205 ,  G01J3/027 ,  G01J3/4412 ,  G01N2201/0636 ,  G01N2201/06113

Abstract: A method, a system, and a non-transitory computer readable medium for accurate Raman spectroscopy. The method may include executing at least one iteration of the steps of: (i) performing, by an optical measurement system, a calibration process that comprises (a) finding a misalignment between a region of interest defined by a spatial filter, and an impinging beam of radiation that is emitted from an illuminated area of a sample, the impinging beam impinges on the spatial filter; and (b) determining a compensating path of propagation of the impinging beam that compensates the misalignment; and (ii) performing a measurement process, while the optical measurement system is configured to provide the compensating path of propagation of the impinging beam, to provide one or more Raman spectra.

公开(公告)号：US11719630B2

公开(公告)日：2023-08-08

申请号：US17310111

申请日：2020-01-15

Applicant: AP2E

Inventor： Alexandre Katchanov ,  Kevin Jaulin ,  Tim Stoltmann ,  Pierre Cholat ,  Lucien Lonigro ,  Bruno Giletta

IPC: G01N21/47 ,  G01J3/44 ,  G01N33/00 ,  G01N21/03

CPC classification number: G01N21/47 ,  G01J3/4412 ,  G01N21/031 ,  G01N33/0004

Abstract: The disclosure relates to a gas analysis method by Raman spectrometry, the method comprising the steps of generating by a laser source a laser beam sweeping a range of frequencies including a plurality of resonance modes of an optical cavity holding gases to be analyzed; delivering the laser beam into the cavity; extracting from the cavity a feedback beam that is sent adjusted in phase and amplitude to the source; during the frequency range sweeping, detecting light intensity peaks in the laser beam in the cavity, the phase of the feedback beam being adjusted to reduce shape asymmetries of the peaks, the amplitude of the feedback beam being adjusted to reduce intervals of zero intensity between the peaks; and performing a spectral analysis of the light inelastically scattered in the cavity, to determine the composition of the gases to be analyzed.