公开(公告)号：US20240374562A1

公开(公告)日：2024-11-14

申请号：US18182153

申请日：2023-03-10

Applicant: EpicentRx, Inc.

Inventor： Bryan T. ORONSKY ,  Jan SCICINSKI ,  Susan KNOX ,  William FITCH ,  Frans A. KUYPERS ,  Marcel FENS ,  Sandra LARKIN ,  Pedro CABRALES ,  Chad BROUSE

IPC: A61K31/397 ,  A01N1/02 ,  A61K31/12 ,  A61K31/16 ,  A61K31/198 ,  A61K31/215 ,  A61K31/22 ,  A61K31/255 ,  A61K31/40 ,  A61K31/445 ,  A61K33/00 ,  A61K35/14 ,  A61K35/16 ,  A61K35/18 ,  A61K38/17 ,  A61K45/06 ,  A61K47/64 ,  A61N5/10

Abstract: The invention provides methods, compositions, and medical kits comprising a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders and preservation of blood products. In one aspect, the invention provides methods, compositions, and medical kits comprising an inorganic nitrite salt and a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders, such as cancer, cardiovascular disorders, ischemic conditions, hemolytic conditions, and bacterial infections. Exemplary inorganic nitrite salts include sodium nitrite and arginine nitrite. Exemplary allosteric modulators of hemoglobin described herein include alkyl-substituted and acyl-substituted di-nitroheterocycles.

公开(公告)号：US20230233524A1

公开(公告)日：2023-07-27

申请号：US18083922

申请日：2022-12-19

Applicant: EpicentRx, Inc.

Inventor： Bryan T. ORONSKY ,  Jan SCICINSKI ,  Scott CAROEN

IPC: A61K31/397 ,  A61P35/02 ,  A61P35/00 ,  A61K9/00 ,  A61K31/194 ,  A61K31/727 ,  A61K35/14 ,  A61K47/10 ,  A61K47/18

CPC classification number: A61K31/397 ,  A61P35/02 ,  A61P35/00 ,  A61K9/0019 ,  A61K31/194 ,  A61K31/727 ,  A61K35/14 ,  A61K47/10 ,  A61K47/18 ,  A61K47/46

Abstract: The invention provides compositions and methods for intravenous administration of 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone (ABDNAZ), including formulations containing, autologous whole blood and ABDNAZ that can be rapidly administered to a patient by intravenous infusion without any significant pain at the site of infusion.