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公开(公告)号：US20220175789A1
公开(公告)日：2022-06-09
申请号：US17526307
申请日：2021-11-15
申请人： Epizyme, Inc.
IPC分类号： A61K31/5377 , A61K45/06 , A61K31/4412 , A61K31/444 , A61K31/475 , A61K31/573 , A61K31/675 , A61K31/704 , A61K39/395 , A61P35/00 , G01N33/574
摘要： The present disclosure relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and one or more other therapeutic agents, particularly anticancer agents such as prednisone, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer.
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公开(公告)号：US20200323866A1
公开(公告)日：2020-10-15
申请号：US16808513
申请日：2020-03-04
发明人： Heike KEILHACK , Sarah K. KNUTSON , Danielle Johnston BLACKWELL , Larisa REYDERMAN , Lone OTTESEN
IPC分类号： A61K31/5377 , C07D213/65 , C07D405/12 , A61K31/4412 , A61K31/4545
摘要： The present invention relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and their use for the treatment of cancer.
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公开(公告)号：US20200022987A1
公开(公告)日：2020-01-23
申请号：US16454835
申请日：2019-06-27
发明人： Heike KEILHACK , Sarah K. KNUTSON , Danielle Johnston BLACKWELL , Larisa REYDERMAN , Lone OTTESEN
IPC分类号： A61K31/5377 , C07D213/65 , C07D405/12 , A61K31/4412 , A61K31/4545
摘要： The present invention relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and their use for the treatment of cancer.
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公开(公告)号：US20190175604A1
公开(公告)日：2019-06-13
申请号：US16181747
申请日：2018-11-06
发明人： Heike KEILHACK , Sarah K. KNUTSON , Danielle Johnston BLACKWELL , Larisa REYDERMAN , Lone OTTESEN
IPC分类号： A61K31/5377 , C07D405/12 , A61K31/4545 , A61K31/4412 , C07D213/65
摘要： The present invention relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and their use for the treatment of cancer.
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公开(公告)号：US20240058348A1
公开(公告)日：2024-02-22
申请号：US18188716
申请日：2023-03-23
发明人： Heike KEILHACK , Sarah K. KNUTSON , Danielle Johnston BLACKWELL , Larisa REYDERMAN , Lone OTTESEN
IPC分类号： A61K31/5377 , C07D213/65 , C07D405/12 , A61K31/4412 , A61K31/4545
CPC分类号： A61K31/5377 , C07D213/65 , C07D405/12 , A61K31/4412 , A61K31/4545
摘要： The present invention relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and their use for the treatment of cancer.
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公开(公告)号：US20190255060A1
公开(公告)日：2019-08-22
申请号：US16250211
申请日：2019-01-17
申请人： Epizyme, Inc.
IPC分类号： A61K31/5377 , A61K31/704 , A61K31/675 , A61K31/573 , A61K31/475 , A61K31/4412 , G01N33/574 , A61P35/00 , A61K45/06 , A61K31/444 , A61K39/395
摘要： The present disclosure relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and one or more other therapeutic agents, particularly anticancer agents such as prednisone, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer.
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公开(公告)号：US20180311251A1
公开(公告)日：2018-11-01
申请号：US15580908
申请日：2016-06-10
申请人： Epizyme, Inc.
IPC分类号： A61K31/5377 , A61P35/00 , A61K45/06 , G01N33/574
CPC分类号： A61K31/4412 , A61K31/444 , A61K31/5377 , A61K45/06
摘要： The present disclosure relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and one or more other therapeutic agents, particularly anticancer agents such as prednisone, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer.
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