公开(公告)号：US20220175789A1

公开(公告)日：2022-06-09

申请号：US17526307

申请日：2021-11-15

Applicant: Epizyme, Inc.

Inventor： Heike KEILHACK ,  Sarah Kathleen KNUTSON ,  Danielle Johnston BLACKWELL

IPC: A61K31/5377 ,  A61K45/06 ,  A61K31/4412 ,  A61K31/444 ,  A61K31/475 ,  A61K31/573 ,  A61K31/675 ,  A61K31/704 ,  A61K39/395 ,  A61P35/00 ,  G01N33/574

Abstract: The present disclosure relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and one or more other therapeutic agents, particularly anticancer agents such as prednisone, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer.

公开(公告)号：US20200323866A1

公开(公告)日：2020-10-15

申请号：US16808513

申请日：2020-03-04

Applicant: Epizyme, Inc. ,  Eisai R&D Management Co., Ltd.

Inventor： Heike KEILHACK ,  Sarah K. KNUTSON ,  Danielle Johnston BLACKWELL ,  Larisa REYDERMAN ,  Lone OTTESEN

IPC: A61K31/5377 ,  C07D213/65 ,  C07D405/12 ,  A61K31/4412 ,  A61K31/4545

Abstract: The present invention relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and their use for the treatment of cancer.

公开(公告)号：US20200022987A1

公开(公告)日：2020-01-23

申请号：US16454835

申请日：2019-06-27

Applicant: Epizyme, Inc. ,  Eisai R&D Management Co., Ltd.

Inventor： Heike KEILHACK ,  Sarah K. KNUTSON ,  Danielle Johnston BLACKWELL ,  Larisa REYDERMAN ,  Lone OTTESEN

IPC: A61K31/5377 ,  C07D213/65 ,  C07D405/12 ,  A61K31/4412 ,  A61K31/4545

Abstract: The present invention relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and their use for the treatment of cancer.

公开(公告)号：US20190175604A1

公开(公告)日：2019-06-13

申请号：US16181747

申请日：2018-11-06

Applicant: Epizyme, Inc. ,  Eisai R&D Management Co., Ltd.

Inventor： Heike KEILHACK ,  Sarah K. KNUTSON ,  Danielle Johnston BLACKWELL ,  Larisa REYDERMAN ,  Lone OTTESEN

IPC: A61K31/5377 ,  C07D405/12 ,  A61K31/4545 ,  A61K31/4412 ,  C07D213/65

Abstract: The present invention relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and their use for the treatment of cancer.

公开(公告)号：US20240058348A1

公开(公告)日：2024-02-22

申请号：US18188716

申请日：2023-03-23

Applicant: Epizyme, Inc. ,  Eisai R&D Management Co., Ltd.

Inventor： Heike KEILHACK ,  Sarah K. KNUTSON ,  Danielle Johnston BLACKWELL ,  Larisa REYDERMAN ,  Lone OTTESEN

IPC: A61K31/5377 ,  C07D213/65 ,  C07D405/12 ,  A61K31/4412 ,  A61K31/4545

CPC classification number: A61K31/5377 ,  C07D213/65 ,  C07D405/12 ,  A61K31/4412 ,  A61K31/4545

Abstract: The present invention relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and their use for the treatment of cancer.

公开(公告)号：US20190255060A1

公开(公告)日：2019-08-22

申请号：US16250211

申请日：2019-01-17

Applicant: Epizyme, Inc.

Inventor： Heike KEILHACK ,  Sarah Kathleen KNUTSON ,  Danielle Johnston BLACKWELL

IPC: A61K31/5377 ,  A61K31/704 ,  A61K31/675 ,  A61K31/573 ,  A61K31/475 ,  A61K31/4412 ,  G01N33/574 ,  A61P35/00 ,  A61K45/06 ,  A61K31/444 ,  A61K39/395

Abstract: The present disclosure relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and one or more other therapeutic agents, particularly anticancer agents such as prednisone, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer.

公开(公告)号：US20180311251A1

公开(公告)日：2018-11-01

申请号：US15580908

申请日：2016-06-10

Applicant: Epizyme, Inc.

Inventor： Heike KEILHACK ,  Sarah K. KNUTSON ,  Danielle Johnston BLACKWELL

IPC: A61K31/5377 ,  A61P35/00 ,  A61K45/06 ,  G01N33/574

CPC classification number: A61K31/4412 ,  A61K31/444 ,  A61K31/5377 ,  A61K45/06

Abstract: The present disclosure relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and one or more other therapeutic agents, particularly anticancer agents such as prednisone, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer.