公开(公告)号：US20080234659A1

公开(公告)日：2008-09-25

申请号：US12052037

申请日：2008-03-20

申请人： Eric Cheng ,  Jianmin Li ,  Weena Bucay-Couto ,  Scott Sanders ,  James F. Schuermann ,  Min-Shyan Sheu

发明人： Eric Cheng ,  Jianmin Li ,  Weena Bucay-Couto ,  Scott Sanders ,  James F. Schuermann ,  Min-Shyan Sheu

IPC分类号： A61M25/00 ,  A61F2/04

CPC分类号： A61L31/16 ,  A61L29/148 ,  A61L29/16 ,  A61L31/148 ,  A61L2300/40 ,  A61M25/0017 ,  A61M27/008 ,  A61M2210/1078 ,  A61M2210/1082 ,  A61M2210/1085

摘要： According to an aspect of the present invention, urological medical devices are provided, which contain one or more urologically beneficial agents selected from alpha-adrenergic blockers, calcium channel blockers, and combinations thereof, among others. The urological devices are adapted for implantation or insertion into a subject's urinary tract, whereupon at least a portion of the urologically beneficial agent is released. Such agents are urologically beneficial, for example, in that they may relieve pain and/or discomfort associated with the medical device and/or act as stone expulsion agents (i.e., they facilitate stone passage), among other benefits. According to an aspect of the present invention, a method of treating kidney stones is provided which comprises: (a) diagnosing the presence of kidney stones within a subject and (b) implanting or inserting a urological medical device into the subject which contains at least one urologically beneficial agent. The medical device is adapted to release the at least one urologically beneficial agent in vivo in an amount effective to promote kidney stone expulsion.

摘要翻译： 根据本发明的一个方面，提供泌尿科医疗装置，其包含一种或多种选自α-肾上腺素能阻滞剂，钙通道阻滞剂及其组合的泌尿功效。 泌尿装置适于植入或插入受试者的尿道中，因此至少一部分泌尿生物有益剂被释放。 这些药物在泌尿学上是有益的，例如，它们可以减轻与医疗装置相关的疼痛和/或不适，和/或作为石头驱逐剂（即它们促进石头通过）以及其它益处。 根据本发明的一个方面，提供了一种治疗肾结石的方法，其包括：（a）诊断受试者内肾结石的存在，以及（b）将泌尿科医疗器械植入或插入至少包含至少 一个泌尿生殖器官。 医疗装置适于以有效促进肾结石排出的量在体内释放至少一种泌尿学有益剂。