-
公开(公告)号:US20150071878A1
公开(公告)日:2015-03-12
申请号:US14539039
申请日:2014-11-12
申请人: Robert Murray McKinnell , Daniel D. Long , Lori Jean Van Orden , Lan Jiang , Mandy Loo , Daisuke Roland Saito , Sheila Zipfel , Eric L. Stangeland , Kassandra Lepack , Gavin Ogawa
发明人: Robert Murray McKinnell , Daniel D. Long , Lori Jean Van Orden , Lan Jiang , Mandy Loo , Daisuke Roland Saito , Sheila Zipfel , Eric L. Stangeland , Kassandra Lepack , Gavin Ogawa
IPC分类号: C07D401/14 , A61K45/06 , A61K31/496
CPC分类号: C07D401/14 , A61K31/496 , A61K45/06 , C07D403/14
摘要: The invention provides compounds of formula (I): wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are inhibitors of replication of the hepatitis C virus. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat hepatitis C viral infections, and processes and intermediates useful for preparing such compounds.
摘要翻译: 本发明提供式(I)化合物:其中变量在说明书中定义,或其药学上可接受的盐,其是丙型肝炎病毒的复制抑制剂。 本发明还提供包含这些化合物的药物组合物,使用这些化合物治疗丙型肝炎病毒感染的方法,以及可用于制备这些化合物的方法和中间体。
-
公开(公告)号:US08921372B2
公开(公告)日:2014-12-30
申请号:US13288216
申请日:2011-11-03
申请人: Robert Murray McKinnell , Daniel D. Long , Lori Jean Van Orden , Lan Jiang , Mandy Loo , Daisuke Roland Saito , Sheila Zipfel , Eric L. Stangeland , Kassandra Lepack , Gavin Ogawa , Xiaojun Huang , Weijiang Zhang
发明人: Robert Murray McKinnell , Daniel D. Long , Lori Jean Van Orden , Lan Jiang , Mandy Loo , Daisuke Roland Saito , Sheila Zipfel , Eric L. Stangeland , Kassandra Lepack , Gavin Ogawa , Xiaojun Huang , Weijiang Zhang
IPC分类号: A61K31/497 , C07D401/14 , C07D403/14 , A61P1/16
CPC分类号: C07D401/14 , A61K31/496 , A61K45/06 , C07D403/14
摘要: The invention provides compounds of formula (I): wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are inhibitors of replication of the hepatitis C virus. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat hepatitis C viral infections, and processes and intermediates useful for preparing such compounds.
摘要翻译: 本发明提供式(I)化合物:其中变量在说明书中定义,或其药学上可接受的盐,其是丙型肝炎病毒的复制抑制剂。 本发明还提供包含这些化合物的药物组合物,使用这些化合物治疗丙型肝炎病毒感染的方法,以及可用于制备这些化合物的方法和中间体。
-
公开(公告)号:US08637568B2
公开(公告)日:2014-01-28
申请号:US13936312
申请日:2013-07-08
IPC分类号: A61K31/40 , C07D207/08
CPC分类号: C07D207/09 , A61K31/40 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D207/08 , C07D403/12 , C07D413/12
摘要: In one aspect, the invention relates to compounds of formula I: where Y, R1, R2, n, and Q are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin reuptake inhibitors. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
摘要翻译: 一方面,本发明涉及式I化合物:其中Y,R 1,R 2,n和Q如说明书中所定义,或其药学上可接受的盐。 式I的化合物是5-羟色胺再摄取抑制剂。 另一方面,本发明涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
-
公开(公告)号:US20130296322A1
公开(公告)日:2013-11-07
申请号:US13936312
申请日:2013-07-08
IPC分类号: C07D207/09 , A61K45/06 , C07D413/12 , A61K31/422 , C07D403/12 , A61K31/41 , A61K31/4196 , A61K31/4245 , A61K31/5377 , A61K31/4155 , A61K31/506 , A61K31/40 , A61K31/4178
CPC分类号: C07D207/09 , A61K31/40 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D207/08 , C07D403/12 , C07D413/12
摘要: In one aspect, the invention relates to compounds of formula I: where Y, R1, R2, n, and Q are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin reuptake inhibitors. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
摘要翻译: 一方面,本发明涉及式I化合物:其中Y,R 1,R 2,n和Q如说明书中所定义,或其药学上可接受的盐。 式I的化合物是5-羟色胺再摄取抑制剂。 另一方面,本发明涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
-
公开(公告)号:US08501964B2
公开(公告)日:2013-08-06
申请号:US13308844
申请日:2011-12-01
IPC分类号: C07D207/08 , A61K31/40
CPC分类号: C07D207/09 , A61K31/40 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D207/08 , C07D403/12 , C07D413/12
摘要: In one aspect, the invention relates to compounds of formula I: where Y, R1, R2, n, and Q are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin reuptake inhibitors. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
摘要翻译: 一方面,本发明涉及式I化合物:其中Y,R 1,R 2,n和Q如说明书中所定义,或其药学上可接受的盐。 式I的化合物是5-羟色胺再摄取抑制剂。 另一方面,本发明涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
-
公开(公告)号:US20160038483A1
公开(公告)日:2016-02-11
申请号:US14883856
申请日:2015-10-15
申请人: Daniel D. Long , Robert Murray McKinnell , Lan Jiang , Mandy Loo , Kassandra Lepack , Lori Jean Van Orden , Gavin Ogawa
发明人: Daniel D. Long , Robert Murray McKinnell , Lan Jiang , Mandy Loo , Kassandra Lepack , Lori Jean Van Orden , Gavin Ogawa
IPC分类号: A61K31/496 , A61K31/5377 , A61K31/541 , A61K45/06
CPC分类号: A61K31/496 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/113
摘要: The invention provides compounds of formula (I): wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are inhibitors of replication of the hepatitis C virus. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat hepatitis C viral infections, and processes and intermediates useful for preparing such compounds.
-
7.
公开(公告)号:US20130287730A1
公开(公告)日:2013-10-31
申请号:US13869199
申请日:2013-04-24
IPC分类号: C07D401/14 , A61K45/06 , C07D487/08 , A61K31/55 , A61K31/496 , A61K31/506
CPC分类号: C07D401/14 , A61K31/496 , A61K31/506 , A61K31/55 , A61K45/06 , C07D405/14 , C07D487/08
摘要: The invention provides compounds of formula (I): wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are inhibitors of replication of the hepatitis C virus. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat hepatitis C viral infections, and processes and intermediates useful for preparing such compounds.
摘要翻译: 本发明提供式(I)化合物:其中变量在说明书中定义,或其药学上可接受的盐,其是丙型肝炎病毒的复制抑制剂。 本发明还提供包含这些化合物的药物组合物,使用这些化合物治疗丙型肝炎病毒感染的方法,以及可用于制备这些化合物的方法和中间体。
-
公开(公告)号:US09212168B2
公开(公告)日:2015-12-15
申请号:US13667197
申请日:2012-11-02
申请人: Daniel D. Long , Robert Murray McKinnell , Lan Jiang , Mandy Loo , Kassandra Lepack , Lori Jean Van Orden , Gavin Ogawa
发明人: Daniel D. Long , Robert Murray McKinnell , Lan Jiang , Mandy Loo , Kassandra Lepack , Lori Jean Van Orden , Gavin Ogawa
IPC分类号: C07D405/14 , C07D401/14 , C07D413/14 , C07D409/14 , C07D491/113
CPC分类号: A61K31/496 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/113
摘要: The invention provides compounds of formula (I): wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are inhibitors of replication of the hepatitis C virus. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat hepatitis C viral infections, and processes and intermediates useful for preparing such compounds.
摘要翻译: 本发明提供式(I)化合物:其中变量在说明书中定义,或其药学上可接受的盐,其是丙型肝炎病毒的复制抑制剂。 本发明还提供包含这些化合物的药物组合物,使用这些化合物治疗丙型肝炎病毒感染的方法,以及可用于制备这些化合物的方法和中间体。
-
9.
公开(公告)号:US09206159B2
公开(公告)日:2015-12-08
申请号:US13869199
申请日:2013-04-24
IPC分类号: C07D401/14 , A61K31/496 , A61K31/506 , A61K31/55 , C07D487/08 , C07D405/14 , A61K45/06
CPC分类号: C07D401/14 , A61K31/496 , A61K31/506 , A61K31/55 , A61K45/06 , C07D405/14 , C07D487/08
摘要: The invention provides compounds of formula (I): wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are inhibitors of replication of the hepatitis C virus. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat hepatitis C viral infections, and processes and intermediates useful for preparing such compounds.
摘要翻译: 本发明提供式(I)化合物:其中变量在说明书中定义,或其药学上可接受的盐,其是丙型肝炎病毒的复制抑制剂。 本发明还提供包含这些化合物的药物组合物,使用这些化合物治疗丙型肝炎病毒感染的方法,以及可用于制备这些化合物的方法和中间体。
-
-
-
-
-
-
-
-