公开(公告)号：US20140308261A1

公开(公告)日：2014-10-16

申请号：US14359442

申请日：2012-11-21

申请人： Etablissement Français du Sang

发明人： Assia El Jaafari ,  Dominique Rigal ,  Diane Scott

IPC分类号： C07K7/08

CPC分类号： C07K7/08 ,  C07K14/47 ,  C07K14/70539

摘要： This invention concerns HY epitopic polypeptides specifically presented by the HLA-DR7 molecule, a method for preparing these epitopic polypeptides, isolated T-lymphocytes capable of specifically recognizing an epitope from these polypeptides or from a polypeptide comprising the complete sequence of the protein encoded by the RPS4Y gene and presented by the HLA-DR7 molecule expressed on the surface of antigen-presenting cells, a method for preparing these T-lymphocytes, as well as the use of these epitopic polypeptides and these T-lymphocytes as medicaments, in particular for the treatment of cancers of immune cells.

摘要翻译： 本发明涉及由HLA-DR7分子特异性表达的HY表位多肽，制备这些表位多肽的方法，能够特异性识别来自这些多肽的表位的分离的T淋巴细胞，或包含由该多肽编码的蛋白质的完整序列的多肽 RPS4Y基因并由抗原呈递细胞表面上表达的HLA-DR7分子呈递，制备这些T淋巴细胞的方法，以及这些表位多肽和这些T淋巴细胞作为药物的用途，特别是用于 治疗免疫细胞癌。