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    Characterizing biological stimuli by response curves
    1.
    发明申请
    Characterizing biological stimuli by response curves 失效
    通过响应曲线表征生物刺激

    公开(公告)号：US20050283317A1

    公开(公告)日：2005-12-22

    申请号：US11186143

    申请日：2005-07-20

    申请人： Eugeni Vaisberg ,  Donald Oestreicher ,  Cynthia Adams

    发明人： Eugeni Vaisberg ,  Donald Oestreicher ,  Cynthia Adams

    IPC分类号： G06F19/00 ,  G06K9/00 ,  G06K9/62 ,  G01N33/48 ,  G01N33/50

    CPC分类号： G06K9/6253 ,  G06F19/70 ,  G06K9/00127

    摘要： A method for generating stimulus response curves (e.g., dose response curves) shows how the phenotype of one or more cells change in response to varying levels of the stimulus. Each “point” on the curve represents quantitative phenotype for cell(s) at a particular level of stimulus (e.g., dose of a therapeutic). The quantitative phenotypes are multivariate phenotypic representations of the cell(s). They include various features of the cell(s) obtained by image analysis. Such features often include basic parameters obtained from images (e.g., cell shape, nucleus area, Golgi texture) and/or biological characterizations derived from the basic parameters (e.g., cell cycle state, mitotic index, etc.). The stimulus response curves may be compared to allow classification of stimuli and identify subtle differences in related stimuli. To facilitate the comparison, it may be desirable to present the response curves in a principal component space.

    摘要翻译： 用于产生刺激响应曲线（例如，剂量反应曲线）的方法示出了一种或多种细胞的表型如何响应于刺激的不同水平而改变。 曲线上的每个“点”表示在特定刺激水平（例如治疗剂的剂量）下的细胞的定量表型。 定量表型是细胞的多变量表型表达。 它们包括通过图像分析获得的细胞的各种特征。 这些特征通常包括从基本参数（例如细胞周期状态，有丝分裂指数等）导出的图像（例如，细胞形状，细胞核区域，高尔基体织构）和/或生物学表征获得的基本参数。 可以比较刺激反应曲线以允许刺激分类并识别相​​关刺激的微妙差异。 为了便于比较，可能期望在主要分量空间中呈现响应曲线。

    Database system including computer code for predictive cellular bioinformatics
    2.
    发明申请
    Database system including computer code for predictive cellular bioinformatics 审中-公开
    数据库系统包括用于预测细胞生物信息学的计算机代码

    公开(公告)号：US20070005263A1

    公开(公告)日：2007-01-04

    申请号：US11436977

    申请日：2006-05-19

    申请人： Eugeni Vaisberg ,  Cynthia Adams ,  James Sabry ,  Anne Crompton

    发明人： Eugeni Vaisberg ,  Cynthia Adams ,  James Sabry ,  Anne Crompton

    IPC分类号： G06F19/00

    CPC分类号： G16B50/00

    摘要： According to the present invention, computer based techniques for using information technology in therapeutics or drug discovery. In an exemplary embodiment, computer based techniques for determining information about the properties of substances based upon information about structure of living or non-living cells exposed to substances are provided. Computer software according to the present invention enables researchers and/or scientists to identify promising candidates in the search for new and better medicines or treatments using, for example, a cellular informatics database.

    摘要翻译： 根据本发明，用于在治疗或药物发现中使用信息技术的基于计算机的技术。 在一个示例性实施例中，提供了基于基于关于暴露于物质的生物体或非活细胞结构的信息来确定关于物质属性的信息的基于计算机的技术。 根据本发明的计算机软件使研究人员和/或科学家能够使用例如蜂窝信息学数据库来识别有希望的候选人寻找新的和更好的药物或治疗。

    HANDHELD DUST-REMOVING DEVICE
    8.
    发明申请
    HANDHELD DUST-REMOVING DEVICE 审中-公开

    公开(公告)号：US20200229670A1

    公开(公告)日：2020-07-23

    申请号：US16251840

    申请日：2019-01-18

    申请人： Cynthia Adams

    发明人： Cynthia Adams

    IPC分类号： A47L13/38

    摘要： A handheld dust-removing device, including a main body to remove at least one particle of dust disposed on a surface of an air conditioning filter, and a handle at least partially disposed within at least a portion of the main body to allow a user to move the main body across the surface of an air conditioning filter to remove the at least one particle of dust.

    Cellular phenotype
    9.
    发明申请
    Cellular phenotype 审中-公开
    细胞表型

    公开(公告)号：US20070082327A1

    公开(公告)日：2007-04-12

    申请号：US11518500

    申请日：2006-09-08

    申请人： Cynthia Adams ,  Reginald de la Rosa ,  Shyamlal Ramchandani ,  Penelope Chua

    发明人： Cynthia Adams ,  Reginald de la Rosa ,  Shyamlal Ramchandani ,  Penelope Chua

    IPC分类号： C12Q1/00 ,  G01N33/574 ,  G06F19/00 ,  C12N5/06

    CPC分类号： G01N33/5008 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/5076 ,  G01N33/5091 ,  G01N33/5308 ,  G01N33/574

    摘要： Phenotypes and the cells that exhibit those phenotypes are described. The phenotype may be established as a “snapshot” of the cells at a particular time or it may be established as a variation in features over time, or as some combination of these “static” and “dynamic” characterizations. The phenotype may be characterized by at least the following features: mitotic arrest characterized (i) chromosomes well-aligned at the metaphase plate and (ii) chromosome residence time at the metaphase plate substantially longer than that of a control cell or cell population. The phenotype may be further characterized by: during interphase the cell or population of cells exhibits a phenotype that is substantially similar to that of the interphase cells of the control cell or cell population.

    摘要翻译： 描述了表型和表现出这些表型的细胞。 表型可以在特定时间被建立为细胞的“快照”，或者可以随时间被确定为特征的变化，或者作为这些“静态”和“动态”表征的某种组合。 该表型可以至少具有以下特征：有丝分裂阻滞的特征在于（i）染色体在中期平板上良好排列，以及（ii）在中期平板上的染色体停留时间比对照细胞或细胞群长得多。 表型的进一步特征在于：在间期期间，细胞或细胞群表现出与对照细胞或细胞群的间期细胞基本相似的表型。