公开(公告)号：US09849147B2

公开(公告)日：2017-12-26

申请号：US14408053

申请日：2012-06-15

申请人： Evangelos Karavas ,  Efthimios Koutris ,  Vasiliki Samara ,  Analia Diakidou ,  Georgia Papanikolaou ,  Panagiotis Mparmpalexis

发明人： Evangelos Karavas ,  Efthimios Koutris ,  Vasiliki Samara ,  Analia Diakidou ,  Georgia Papanikolaou ,  Panagiotis Mparmpalexis

IPC分类号： A61K31/785 ,  A61K9/00 ,  A61K9/20

CPC分类号： A61K31/785 ,  A61K9/0056 ,  A61K9/2027

摘要： The present invention relates to a fast dissolving tablet comprising a therapeutically effective amount of a phosphate binding polymer, such as sevelamer or pharmaceutically acceptable salt or derivative thereof, that exhibit limited swelling in the oral cavity, has pleasant taste and mouth feel, high phosphate binding capacity with fast binding kinetics and require limited amount of water intake. A process for the preparation thereof is disclosed.

公开(公告)号：US20150182555A1

公开(公告)日：2015-07-02

申请号：US14408053

申请日：2012-06-15

申请人： Evangelos Karavas ,  Efthimios Koutris ,  Vasiliki Samara ,  Analia Diakidou ,  Georgia Papanikolaou ,  Panagiotis Mparmpalexis

发明人： Evangelos Karavas ,  Efthimios Koutris ,  Vasiliki Samara ,  Analia Diakidou ,  Georgia Papanikolaou ,  Panagiotis Mparmpalexis

IPC分类号： A61K31/785

CPC分类号： A61K31/785 ,  A61K9/0056 ,  A61K9/2027

摘要： The present invention relates to a fast dissolving tablet comprising a therapeutically effective amount of a phosphate binding polymer, such as sevelamer or pharmaceutically acceptable salt or derivative thereof, that exhibit limited swelling in the oral cavity, has pleasant taste and mouth feel, high phosphate binding capacity with fast binding kinetics and require limited amount of water intake. A process for the preparation thereof is disclosed.

摘要翻译： 本发明涉及一种快速溶解片剂，其包含治疗有效量的在口腔中显示有限肿胀的磷酸结合聚合物，如司维拉姆或其药学上可接受的盐或衍生物，具有令人愉快的口感和口感，高磷酸盐结合 容量具有快速结合动力学，并且需要有限量的水摄入量。 公开了其制备方法。