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公开(公告)号：US09849147B2
公开(公告)日：2017-12-26
申请号：US14408053
申请日：2012-06-15
申请人： Evangelos Karavas , Efthimios Koutris , Vasiliki Samara , Analia Diakidou , Georgia Papanikolaou , Panagiotis Mparmpalexis
发明人： Evangelos Karavas , Efthimios Koutris , Vasiliki Samara , Analia Diakidou , Georgia Papanikolaou , Panagiotis Mparmpalexis
IPC分类号： A61K31/785 , A61K9/00 , A61K9/20
CPC分类号： A61K31/785 , A61K9/0056 , A61K9/2027
摘要： The present invention relates to a fast dissolving tablet comprising a therapeutically effective amount of a phosphate binding polymer, such as sevelamer or pharmaceutically acceptable salt or derivative thereof, that exhibit limited swelling in the oral cavity, has pleasant taste and mouth feel, high phosphate binding capacity with fast binding kinetics and require limited amount of water intake. A process for the preparation thereof is disclosed.
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2.发明申请PHARMACEUTICAL FORMULATION CONTAINING AN HMG-COA REDUCTASE INHIBITOR AND METHOD FOR THE PREPARATION THEREOF 有权包含HMG-COA还原酶抑制剂的药物制剂及其制备方法公开(公告)号：US20100137400A1
公开(公告)日：2010-06-03
申请号：US12063447
申请日：2006-05-12
申请人： Evangelos Karavas , Efthimios Koutris , Elisavet Ioannidou , Eleni Stathaki , Dimitrios Bikiaris
发明人： Evangelos Karavas , Efthimios Koutris , Elisavet Ioannidou , Eleni Stathaki , Dimitrios Bikiaris
IPC分类号： A61K31/405 , C07D209/18 , C07D207/34 , A61K31/40 , A61P9/10
摘要： The present invention relates to improved pharmaceutical formulation for oral administration comprising a therapeutically effective quantity of an HMG-CoA reductase inhibitor, and more particularly Fluvastatin, Atorvastatin or salts thereof in combination with a linear sulphated polysaccharide such as Carrageenan and a method for the preparation thereof.
摘要翻译： 本发明涉及用于口服给药的改进的药物制剂，其包含治疗有效量的HMG-CoA还原酶抑制剂，更具体地，氟伐他汀，阿托伐他汀或其盐与线性硫酸化多糖如角叉菜胶的组合及其制备方法 。
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公开(公告)号：US09675551B2
公开(公告)日：2017-06-13
申请号：US14353074
申请日：2011-10-25
IPC分类号： A61K9/00 , A61K9/20 , A61K31/522 , A61K31/138
CPC分类号： A61K9/006 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2095 , A61K31/138 , A61K31/522 , A61K2300/00
摘要： The present invention relates to a stable pharmaceutical composition for sublingual administration comprising a therapeutically effective quantity of an antihistamine agent, in particular Dimenhydnnate and a process for the preparation thereof.
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4.发明申请NOVEL METHOD FOR IMPROVING THE BIOAVAILABILITY OF LOW AQUEOUS SOLUBILITY DRUGS 有权改善低水溶性药物生物可利用性的新方法公开(公告)号：US20150290137A1
公开(公告)日：2015-10-15
申请号：US14443094
申请日：2012-11-30
申请人： Evangelos Karavas , Efthimios Koutris , Vasiliki Samara , Amalia Diakidou , Georgia Papanikolaou
发明人： Evangelos Karavas , Efthimios Koutris , Vasiliki Samara , Amalia Diakidou , Georgia Papanikolaou
IPC分类号： A61K9/20 , A61K31/40 , A61K31/4535 , A61K31/4985 , A61K31/42
CPC分类号： A61K9/2013 , A61K9/2009 , A61K9/2027 , A61K9/2095 , A61K31/40 , A61K31/42 , A61K31/4535 , A61K31/4985 , A61K47/22
摘要： The present invention relates to the implementation of a new method for manufacturing solid dosage forms for oral administration comprising poorly water soluble active ingredients which overcomes the associated solubility problems and affords improved dissolution profile.
摘要翻译： 本发明涉及用于制造用于口服给药的固体剂型的新方法的实施，其包含难溶的水溶性活性成分，其克服了相关的溶解度问题并提供改善的溶出曲线。
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5.发明申请公开(公告)号：US20110033538A1
公开(公告)日：2011-02-10
申请号：US12739475
申请日：2007-10-16
申请人： Evangelos Karavas , Efthimios Koutris , Dimitrios Bikiaris , Vicky Samara , Ioanna Koutri , Eleni Stathaki
发明人： Evangelos Karavas , Efthimios Koutris , Dimitrios Bikiaris , Vicky Samara , Ioanna Koutri , Eleni Stathaki
IPC分类号： A61K31/4015 , A61K9/28 , A61P25/08
CPC分类号： A61K31/4015 , A61K9/2009 , A61K9/2027 , A61K9/2054 , A61K9/2095
摘要： The present invention relates to a pharmaceutical formulation of solid dosage forms comprising a therapeutically effective amount of a pyrrolidone anticonvulsant agent, and in particular Levetiracetam or a pharmaceutical acceptable salt or derivative thereof, in combination with an effective diluent, such as Dibasic Calcium Phosphate, and additional pharmaceutical excipients, and a process for the preparation thereof by wet granulation.
摘要翻译： 本发明涉及一种固体剂型的药物制剂，其包含治疗有效量的吡咯烷酮抗惊厥剂，特别是左乙拉西坦或其药学上可接受的盐或衍生物，与有效稀释剂如磷酸氢二钙和 另外的药物赋形剂，以及通过湿法制粒制备方法。
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公开(公告)号：US10772830B1
公开(公告)日：2020-09-15
申请号：US16830883
申请日：2020-03-26
申请人： Evangelos Karavas , Efthimios Koutris , Vasiliki Samara , Ioanna Koutri , Anastasia Kalaskani , Andreas Kakouris , George Gotzamanis
发明人： Evangelos Karavas , Efthimios Koutris , Vasiliki Samara , Ioanna Koutri , Anastasia Kalaskani , Andreas Kakouris , George Gotzamanis
IPC分类号： A61K31/5575 , A61K47/00 , A61K47/12 , A61K9/00 , A61K47/26 , A61K47/10 , A61K47/38 , A61K9/08 , A61K31/165 , A61K31/5377 , A61K31/382 , A61K47/02
摘要： The present invention relates to a preservative-free, aqueous solution in the form of eye drops packed in a container that ensures stability of the product, ideal eye drop volume and reduced drop volume variability and provides efficient dispensing.
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7.发明申请公开(公告)号：US20200237920A1
公开(公告)日：2020-07-30
申请号：US16851779
申请日：2020-04-17
申请人： EVANGELOS KARAVAS , EFTHIMIOS KOUTRIS , DIMITRIOS BIKIARIS , SOTIRIA CHATIDOU , AMALIA DIAKIDOU , PANAGIOTIS BARMPALEXIS , LOUIZA KONSTANTI , KATERINA MINIOTI
发明人： EVANGELOS KARAVAS , EFTHIMIOS KOUTRIS , DIMITRIOS BIKIARIS , SOTIRIA CHATIDOU , AMALIA DIAKIDOU , PANAGIOTIS BARMPALEXIS , LOUIZA KONSTANTI , KATERINA MINIOTI
IPC分类号： A61K47/38 , A61K31/5377 , A61K9/00 , A61K9/70 , A61K31/675 , A61K47/14 , A61K47/34 , A61K47/44 , A61K47/46
摘要： The present invention relates to a controlled release sterile injectable formulation in the form of solution, suspension or sol-gel formulation for intramuscular or subcutaneous administration comprising a therapeutically effective amount of a neurokinin 1 receptor antagonist, in particular Aprepitant or Fosaprepitant or pharmaceutical acceptable salt, derivative or metabolite thereof. It also relates to a process for developing such formulations.
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8.发明申请STABLE INJECTABLE PHARMACEUTICAL COMPOSITION OF NEUROKININ 1 RECEPTOR ANTAGONIST AND PROCESS FOR PREPARATION THEREOF 审中-公开神经营养因子1受体拮抗剂稳定的注射用药物组合物及其制备方法公开(公告)号：US20150165045A1
公开(公告)日：2015-06-18
申请号：US14412147
申请日：2012-07-06
申请人： Evangelos Karavas , Efthimios Koutris , Dimitrios Bikiaris , Sotiria Chatidou , Amalia Diakidou , Panagiotis Barmpalexis , Louiza Konstanti , Katerina Minioti
发明人： Evangelos Karavas , Efthimios Koutris , Dimitrios Bikiaris , Sotiria Chatidou , Amalia Diakidou , Panagiotis Barmpalexis , Louiza Konstanti , Katerina Minioti
IPC分类号： A61K47/38 , A61K31/675 , A61K47/34 , A61K47/44 , A61K47/14 , A61K47/46 , A61K31/5377 , A61K9/00
CPC分类号： A61K47/38 , A61K9/0014 , A61K9/0019 , A61K9/7015 , A61K31/5377 , A61K31/675 , A61K47/14 , A61K47/34 , A61K47/44 , A61K47/46
摘要： The present invention relates to a controlled release sterile injectable formulation in the form of solution, suspension or sol-gel formulation for intramuscular or subcutaneous administration comprising a therapeutically effective amount of a neurokinin 1 receptor antagonist, in particular Aprepitant or Fosaprepitant or pharmaceutical acceptable salt, derivative or metabolite thereof. It also relates to a process for developing such formulations.
摘要翻译： 本发明涉及用于肌内或皮下给药的溶液，悬浮液或溶胶 - 凝胶制剂形式的控释免疫可注射制剂，其包含治疗有效量的神经激肽1受体拮抗剂，特别是阿维菌素或福沙吡啶或药学上可接受的盐， 衍生物或代谢物。 它还涉及开发这种制剂的方法。
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9.发明申请OPHTHALMIC PHARMACEUTICAL COMPOSITION CONTAINING A CARBONIC ANHYDRASE INHIBITOR AND METHOD FOR THE PREPARATION THEREOF 审中-公开含有碳氢化合物抑制剂的透明药物组合物及其制备方法公开(公告)号：US20150080385A1
公开(公告)日：2015-03-19
申请号：US14386604
申请日：2013-03-08
申请人： Evangelos Karavas , Efthimios Koutris , Vasiliki Samara , Efstathia Milouli , Ioanna Kontiza , Ioanna Koutri
发明人： Evangelos Karavas , Efthimios Koutris , Vasiliki Samara , Efstathia Milouli , Ioanna Kontiza , Ioanna Koutri
摘要： The present invention relates to a stable pharmaceutical formulation for topical administration containing a therapeutically effective quantity of Brinzolamide or ophthalmologic acceptable salts thereof and an effective quantity of a surfactant such as poloxamer, to be used for the treatment of ocular hypertension and glaucoma.
摘要翻译： 本发明涉及用于局部给药的稳定药物制剂，其含有治疗有效量的布氮唑胺或其眼科可接受的盐和有效量的表面活性剂如泊洛沙姆，用于治疗眼高压和青光眼。
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10.发明申请公开(公告)号：US20140235656A1
公开(公告)日：2014-08-21
申请号：US14353074
申请日：2011-10-25
IPC分类号： A61K9/00 , A61K9/20 , A61K31/522
CPC分类号： A61K9/006 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2095 , A61K31/138 , A61K31/522 , A61K2300/00
摘要： The present invention relates to a stable pharmaceutical composition for sublingual administration comprising a therapeutically effective quantity of an antihistamine agent, in particular Dimenhydnnate and a process for the preparation thereof.
摘要翻译： 本发明涉及用于舌下施用的稳定的药物组合物，其包含治疗有效量的抗组胺剂，特别是二氢萘酸酯及其制备方法。
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