公开(公告)号：US12296067B2

公开(公告)日：2025-05-13

申请号：US17414752

申请日：2019-12-19

Applicant: Evolved by Nature, Inc.

Inventor： Gregory H. Altman ,  Rebecca L. Lacouture ,  Peng Xu ,  Erlei Jin ,  Carlos J. Bosques ,  Patrick Yacono ,  Patrik Johansson

IPC: A61L27/26 ,  A61K8/64 ,  A61K8/73 ,  A61K8/86 ,  A61L27/36 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61Q19/08

Abstract: Hyaluronic acid and silk fibroin or silk fibroin fragments tissue fillers and methods of making and using the same are provided herein. In some embodiments, the disclosure relates to a biocompatible tissue filler comprising silk fibroin or silk fibroin fragments, hyaluronic acid (HA), and polyethylene glycol (PEG) and/or polypropylene glycol (PPG), wherein a portion of the HA is modified or crosslinked by one or more linker moieties comprising one or more of polyethylene glycol (PEG), polypropylene glycol (PPG), and a secondary alcohol, wherein the linker moieties are attached to the HA at one end of the linker.