公开(公告)号：US20180153967A1

公开(公告)日：2018-06-07

申请号：US15735161

申请日：2016-06-06

申请人： Evonik Roehm GmbH

发明人： Juan Tome-Alcalde ,  Norbert Windhab ,  Melanie Liefke ,  Anne Benedikt ,  Jessica Müller-Albers ,  Tom Tice ,  Susanne Ullrich ,  Andrea Engel ,  Matthias Germer ,  Steffen Kistner ,  Jens Daufenbach

IPC分类号： A61K38/36 ,  A61K38/48 ,  A61K38/49 ,  A61K9/16 ,  A61K9/19

CPC分类号： A61K38/36 ,  A61K9/1647 ,  A61K9/19 ,  A61K9/5153 ,  A61K38/4846 ,  A61K38/4866 ,  A61K38/49 ,  A61K47/34

摘要： A process for preparing a powder, which includes one or more human coagulation factor proteins and a lactic acid polymer, involves mixing and dispersing a lactic acid polymer with a particle size d50 in the range 0.1-2 μm and the one or more human coagulation factor proteins in water. The dispersion is dried, and the resulting dried mass is compressed. The resulting compressed dried mass is comminuted to a powder with a particle size d50 in the range of more than 0.5 and up to 5 μm.

公开(公告)号：US10322169B2

公开(公告)日：2019-06-18

申请号：US15735161

申请日：2016-06-06

申请人： Evonik Roehm GmbH

发明人： Juan Tome-Alcalde ,  Norbert Windhab ,  Melanie Liefke ,  Anne Benedikt ,  Jessica Müller-Albers ,  Tom Tice ,  Susanne Ullrich ,  Andrea Engel ,  Matthias Germer ,  Steffen Kistner ,  Jens Daufenbach

IPC分类号： A61K38/00 ,  A61K38/36 ,  A61K9/16 ,  A61K9/19 ,  A61K38/48 ,  A61K38/49 ,  A61K47/34 ,  A61K9/51

摘要： A process for preparing a powder, which includes one or more human coagulation factor proteins and a lactic acid polymer, involves mixing and dispersing a lactic acid polymer with a particle size d50 in the range 0.1-2 μm and the one or more human coagulation factor proteins in water. The dispersion is dried, and the resulting dried mass is compressed. The resulting compressed dried mass is comminuted to a powder with a particle size d50 in the range of more than 0.5 and up to 5 μm.