公开(公告)号：US09480654B2

公开(公告)日：2016-11-01

申请号：US13648846

申请日：2012-10-10

申请人： EVONIK ROEHM GmbH

发明人： Matthias Seiler ,  Norbert Windhab ,  Manfred Stickler ,  Hans-Ulrich Petereit

IPC分类号： A61K38/00 ,  A61K9/14 ,  A61K9/16 ,  A61K47/34 ,  A61K47/48

CPC分类号： A61K9/146 ,  A61K9/1641 ,  A61K47/34 ,  A61K47/59 ,  A61K47/595 ,  A61K47/62

摘要： The invention relates to novel particulate drug-delivery systems based on a polymer support containing at least one linear, branched or cross-linked polymer in a fraction of over 50 percent by weight in relation to the total weight of the support. The system is characterized in that at least one signal substance for transport through a biological barrier and at least one active ingredient are stored, the support, signal substance and active ingredient having no covalent links and no active-ingredient specific and signal substance specific coordinative links between one another.

摘要翻译： 本发明涉及基于聚合物载体的新型颗粒药物递送系统，其包含至少一种相对于载体总重量超过50重量％的直链，支链或交联聚合物。 该系统的特征在于，存储用于传输通过生物屏障和至少一种活性成分的至少一种信号物质，所述载体，信号物质和没有共价连接并且没有活性成分特异性和信号物质特异性协调链接的信号物质和活性成分 在彼此之间

公开(公告)号：US10322169B2

公开(公告)日：2019-06-18

申请号：US15735161

申请日：2016-06-06

申请人： Evonik Roehm GmbH

发明人： Juan Tome-Alcalde ,  Norbert Windhab ,  Melanie Liefke ,  Anne Benedikt ,  Jessica Müller-Albers ,  Tom Tice ,  Susanne Ullrich ,  Andrea Engel ,  Matthias Germer ,  Steffen Kistner ,  Jens Daufenbach

IPC分类号： A61K38/00 ,  A61K38/36 ,  A61K9/16 ,  A61K9/19 ,  A61K38/48 ,  A61K38/49 ,  A61K47/34 ,  A61K9/51

摘要： A process for preparing a powder, which includes one or more human coagulation factor proteins and a lactic acid polymer, involves mixing and dispersing a lactic acid polymer with a particle size d50 in the range 0.1-2 μm and the one or more human coagulation factor proteins in water. The dispersion is dried, and the resulting dried mass is compressed. The resulting compressed dried mass is comminuted to a powder with a particle size d50 in the range of more than 0.5 and up to 5 μm.

公开(公告)号：US20180318211A1

公开(公告)日：2018-11-08

申请号：US15776043

申请日：2016-11-11

申请人： Evonik Roehm GmbH

发明人： Norbert Windhab ,  Rima Jaber ,  Axel Schroeder ,  Kevin Burton ,  Tom Tice

IPC分类号： A61K9/00 ,  A61K47/34 ,  A61K31/536 ,  A61K47/22 ,  A61K31/505 ,  A61K45/06

CPC分类号： A61K9/0024 ,  A61K31/505 ,  A61K31/536 ,  A61K45/06 ,  A61K47/22 ,  A61K47/34 ,  A61K2300/00

摘要： An injection solution can be used in a pharmaceutical dosage formulation. The injection solution includes an organic solvent, a copolymer, which is a poly(lactide-co-glycolide) dissolved in the organic solvent, and a pharmaceutical active ingredient, which is a non-nucleoside inhibitor of the HIV reverse transcriptase or of the HIV integrase, and which contains aromatic and heterocyclic aromatic or aromatic and heterocyclic aromatic and aliphatic heterocyclic groups, where a content of the pharmaceutical active ingredient is from about 8 to about 25% by weight of the copolymer solution.

公开(公告)号：US10406098B2

公开(公告)日：2019-09-10

申请号：US15776043

申请日：2016-11-11

申请人： Evonik Roehm GmbH

发明人： Norbert Windhab ,  Rima Jaber ,  Axel Schroeder ,  Kevin Burton ,  Tom Tice

IPC分类号： A61K31/505 ,  A61K9/00 ,  A61K47/22 ,  A61K47/34 ,  A61K31/536 ,  A61K45/06

摘要： An injection solution can be used in a pharmaceutical dosage formulation. The injection solution includes an organic solvent, a copolymer, which is a poly(lactide-co-glycolide) dissolved in the organic solvent, and a pharmaceutical active ingredient, which is a non-nucleoside inhibitor of the HIV reverse transcriptase or of the HIV integrase, and which contains aromatic and heterocyclic aromatic or aromatic and heterocyclic aromatic and aliphatic heterocyclic groups, where a content of the pharmaceutical active ingredient is from about 8 to about 25% by weight of the copolymer solution.

公开(公告)号：US20180153967A1

公开(公告)日：2018-06-07

申请号：US15735161

申请日：2016-06-06

申请人： Evonik Roehm GmbH

发明人： Juan Tome-Alcalde ,  Norbert Windhab ,  Melanie Liefke ,  Anne Benedikt ,  Jessica Müller-Albers ,  Tom Tice ,  Susanne Ullrich ,  Andrea Engel ,  Matthias Germer ,  Steffen Kistner ,  Jens Daufenbach

IPC分类号： A61K38/36 ,  A61K38/48 ,  A61K38/49 ,  A61K9/16 ,  A61K9/19

CPC分类号： A61K38/36 ,  A61K9/1647 ,  A61K9/19 ,  A61K9/5153 ,  A61K38/4846 ,  A61K38/4866 ,  A61K38/49 ,  A61K47/34

摘要： A process for preparing a powder, which includes one or more human coagulation factor proteins and a lactic acid polymer, involves mixing and dispersing a lactic acid polymer with a particle size d50 in the range 0.1-2 μm and the one or more human coagulation factor proteins in water. The dispersion is dried, and the resulting dried mass is compressed. The resulting compressed dried mass is comminuted to a powder with a particle size d50 in the range of more than 0.5 and up to 5 μm.