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公开(公告)号：US20250134880A1
公开(公告)日：2025-05-01
申请号：US19007899
申请日：2025-01-02
Applicant: Exelixis, Inc.
Inventor： Jo Ann Wilson , Khalid Shah
Abstract: Pharmaceutical compositions and unit dosage forms comprising Compound (I) are disclosed.
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公开(公告)号：US20210154185A1
公开(公告)日：2021-05-27
申请号：US17152394
申请日：2021-01-19
Applicant: Exelixis, Inc.
Inventor： Jo Ann Wilson , Khalid Shah
IPC: A61K31/47 , C07D215/233
Abstract: The present invention is directed to processes for making and compositions containing quinolines such as formula I or pharmaceutically acceptable salts thereof wherein: X1 is H, Br, CI, or X2 is H, Br, CI, or n1 is 1-2; and n2 is 1-2.
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公开(公告)号：US20170266178A1
公开(公告)日：2017-09-21
申请号：US15612703
申请日：2017-06-02
Applicant: Exelixis, Inc.
Inventor： Jo Ann Wilson , Khalid Shah
CPC classification number: A61K31/47 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K9/2095 , A61K9/28 , A61K9/2833 , A61K9/2866 , A61K9/2893 , A61K45/06
Abstract: Pharmaceutical compositions and unit dosage forms comprising Compound I are disclosed.
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公开(公告)号：US20170143689A1
公开(公告)日：2017-05-25
申请号：US15426804
申请日：2017-02-07
Applicant: Exelixis, Inc.
Inventor： Jo Ann Wilson , Khalid Shah
CPC classification number: A61K31/47 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K9/2095 , A61K9/28 , A61K9/2833 , A61K9/2866 , A61K9/2893 , A61K45/06
Abstract: Pharmaceutical compositions and unit dosage forms comprising Compound I are disclosed.
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公开(公告)号：US12128039B2
公开(公告)日：2024-10-29
申请号：US18436836
申请日：2024-02-08
Applicant: Exelixis, Inc.
Inventor： Jo Ann Wilson , Khalid Shah
IPC: A61K31/47 , C07D215/233
CPC classification number: A61K31/47 , C07D215/233
Abstract: The present invention is directed to processes for making and compositions containing quinolines such as formula I or pharmaceutically acceptable salts thereof wherein: X1 is H, Br, CI, or X2 is H, Br, CI, or n1 is 1-2; and n2 is 1-2.
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Patent Agency Ranking
6.发明公开公开(公告)号：US20240189298A1
公开(公告)日：2024-06-13
申请号：US18436836
申请日：2024-02-08
Applicant: Exelixis, Inc.
Inventor： Jo Ann Wilson , Khalid Shah
IPC: A61K31/47 , C07D215/233
CPC classification number: A61K31/47 , C07D215/233
Abstract: The present invention is directed to processes for making and compositions containing quinolines such as formula I or pharmaceutically acceptable salts thereof wherein: X1 is H, Br, CI, or X2 is H, Br, CI, or n1 is 1-2; and n2 is 1-2.
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公开(公告)号：US20220370436A1
公开(公告)日：2022-11-24
申请号：US17869427
申请日：2022-07-20
Applicant: Exelixis, Inc.
Inventor： Jo Ann Wilson , Khalid Shah
Abstract: Pharmaceutical compositions and unit dosage forms comprising Compound (I) are disclosed.
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8.发明申请公开(公告)号：US20190030021A1
公开(公告)日：2019-01-31
申请号：US16151653
申请日：2018-10-04
Applicant: Exelixis, Inc.
Inventor： Jo Ann Wilson , Khalid Shah
IPC: A61K31/47 , C07D215/233
Abstract: The present invention is directed to processes for making and compositions containing quinolines such as formula I or pharmaceutically acceptable salts thereof wherein: X1 is H, Br, Cl, or X2 is H, Br, Cl, or n1 is 1-2; and n2 is 1-2.
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公开(公告)号：US09969692B2
公开(公告)日：2018-05-15
申请号：US15133708
申请日：2016-04-20
Applicant: Exelixis, Inc.
Inventor： Jo Ann Wilson , Sriram Naganathan , Neil G. Andersen , Matthew Pfeiffer
IPC: C07D215/00 , C07D215/233 , C07D239/90 , C07C231/02
CPC classification number: C07D215/233 , C07C231/02 , C07C233/58 , C07C233/59 , C07D215/00 , C07D239/90
Abstract: A process for preparing a compound of Formula I is disclosed, comprising the steps: wherein: R1 is halo; R2 is halo; R3 is (C1-C6)alkyl or (C1-C6)alkyl optionally substituted with heterocycloalkyl; R4 is (C1-C6)alkyl; and Q is CH or N; comprising: (a) contacting 1,1-cyclopropane dicarboxylic acid with thionyl chloride in a polar aprotic solvent; (b) adding and a tertiary amine base to the mixture of step (a) to form a compound of Formula A; and (c) coupling a compound of Formula A with an amine of Formula B to form a compound of Formula I.
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10.发明申请Processes for Preparing Quinoline Compounds and Pharmaceutical Compositions Containing Such Compounds 审中-公开制备喹啉化合物和含有这些化合物的药物组合物的方法公开(公告)号：US20170057921A1
公开(公告)日：2017-03-02
申请号：US15348716
申请日：2016-11-10
Applicant: Exelixis, Inc.
Inventor： Jo Ann Wilson , Khalid Shah
IPC: C07D215/233
CPC classification number: A61K31/47 , C07D215/233
Abstract: The present invention is directed to processes for making and compositions containing quinolines such as formula I or pharmaceutically acceptable salts thereof wherein: X1 is H, Br, Cl, or X2 is H, Br, Cl, or n1 is 1-2; and n2 is 1-2.
Abstract translation: 本发明涉及制备方法和含有喹啉如式I或其药学上可接受的盐的组合物，其中：X 1是H，Br，Cl或X 2是H，Br，Cl或n 1是1-2; n2为1-2。
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