公开(公告)号：US20040142474A1

公开(公告)日：2004-07-22

申请号：US10717109

申请日：2003-11-19

Applicant: Expression Genetics, Inc.

Inventor： Ram I. Mahato ,  Sang-Oh Han ,  Darin Y. Furgeson ,  Khursheed Anwer

IPC: C08G063/48 ,  C08G063/91 ,  C12N015/88

CPC classification number: C08G73/0206 ,  A61K9/1272 ,  A61K47/645 ,  A61K48/0041

Abstract: A biodegradable cationic lipopolymer comprising a polyethylenimine (PEI), a lipid, and a biocompatible hydrophilic polymer, wherein 1) the lipid and the biocompatible hydrophilic polymer are directly linked to the PEI backbone or 2) the lipid is linked to the PEI backbone through the biocompatible hydrophilic polymer. The cationic lipopolymers of the present invention can be used for delivery of a nucleic acid or any anionic bioactive agent to various organs and tissues after local or systemic administration.

Abstract translation: 包含聚乙烯亚胺（PEI），脂质和生物相容性亲水性聚合物的可生物降解的阳离子脂质聚合物，其中1）脂质和生物相容的亲水性聚合物直接连接到PEI主链或2）脂质通过 生物相容性亲水性聚合物。 本发明的阳离子脂质体聚合物可用于在局部或全身给药后将核酸或任何阴离子生物活性剂递送至各种器官和组织。