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    Zero length cross-linking of proteins and related compounds
    1.
    发明申请
    Zero length cross-linking of proteins and related compounds 审中-公开
    蛋白质和相关化合物的零长度交联

    公开(公告)号：US20040260019A1

    公开(公告)日：2004-12-23

    申请号：US10487433

    申请日：2004-08-13

    Inventor： Harvey Kaplan ,  Mary Alice Hefford ,  Brigitte Leanne Simons

    IPC: C08G063/48 ,  C08G063/91

    CPC classification number: C12N9/2462 ,  C07K1/1077 ,  C12N9/22 ,  C12N11/08 ,  C12Y302/01017

    Abstract: The invention relates to a method of cross-linking poly(amino acid) compounds (e.g. proteins, polypeptides, protein polymers, etc.) to each other or attaching such compounds to polyamino or polycarboxyl compounds. The method involves lyophilizing a solution of at least one poly(amino acid) compound, or at least one poly(amino acid) compound and a polyamino or polycarboxyl compound, maintaining the lyophilized solid under vacuum, heating the lyophilized solid under vacuum to an elevated temperature effective to cause cross-linking without denaturing of the poly(amino acid) compounds, and cooling the product and releasing the vacuum. The method produces cross-linking without the use of activating compounds or cross-linking molecules. The invention also relates to novel cross-linked products.

    Electroactive complex, electroactive probe and preparation method
    2.
    发明申请
    Electroactive complex, electroactive probe and preparation method 审中-公开
    电活性复合物，电活性探针及其制备方法

    公开(公告)号：US20040209252A1

    公开(公告)日：2004-10-21

    申请号：US10257783

    申请日：2002-11-15

    Inventor： Francis Garnier

    IPC: C12Q001/68 ,  G01N033/53 ,  C08G063/48 ,  C08G063/91 ,  G01N027/26

    CPC classification number: C08G61/124 ,  C08G61/122 ,  G01N33/58 ,  H01B1/124

    Abstract: The invention concerns an electroactive complex, consisting of an electroactive homopolymer or copolymer polymer of at least two monomers, and anti-ligand and a ligand having specifically interacted with said antiligand, and further at least an electron donor group, and an electroactive probe, consisting of said polymer said antiligand capable of interacting specifically with said ligand and at least an electron donor group.

    Abstract translation: 本发明涉及由至少两种单体的电活性均聚物或共聚物聚合物组成的电活性复合物，以及与所述抗配糖特异性相互作用的抗配体和配体，以及至少一种电子给体基团和电活性探针，其包含 的所述聚合物，所述抗配体能够与所述配体和至少电子给体基团特异性相互作用。

    Biodegradable polyacetals
    3.
    发明申请
    Biodegradable polyacetals 失效
    可生物降解聚缩醛

    公开(公告)号：US20040166089A1

    公开(公告)日：2004-08-26

    申请号：US10375705

    申请日：2003-02-25

    Inventor： Lei Yu ,  Sang Van ,  Shouping Ji ,  Kenji Matsumoto

    IPC: A61K031/785 ,  C08G063/48 ,  C08G063/91

    CPC classification number: C08G73/0213 ,  A61K47/59 ,  C08G65/002

    Abstract: A polymer comprising recurring units represented by formula (I): 1 wherein X is selected from the group consisting of C(O)OR1, C(O)SR1, C(O)NR1R2, and VZ, where R1 and R2 are each individually selected from the group consisting of hydrogen, C1 to C10 alkyl, and C6 to C10 aryl, where V is a labile linker group, and where Z is selected from the group consisting of poly(ethyleneimine), poly(propyleneimine), poly(lysine), PAMAM dendrimer, octaamine dendrimer, and hexadecaamine dendrimer; and wherein Y is selected from the group consisting of null(CH2)2null, null(CH2)2nullOnull(CH2)2null, null(CH2)2nullOnull(CH2)2nullOnull(CH2)2null, and null(CH2)3nullNHC(O)null(CH2)6nullC(O)NHnull(CH2)3null is useful in nucleic acid delivery applications. Polyacetals of the formula (I) are preferably made by reacting appropriate diols and divinyl ethers. In preferred embodiments, complexes formed between polyacetals of the formula (I) and polynucleotides are useful as transfection reagents.

    Abstract translation: 一种包含由式（I）表示的重复单元的聚合物：其中X选自C（O）OR 1，C（O）SR 1，C（O）NR 1 R 2 >和VZ，其中R 1和R 2各自独立地选自氢，C 1至C 10烷基和C 6至C 10芳基，其中V是不稳定的连接基团，并且其中Z被选择 由聚（乙烯亚胺），聚（丙烯亚胺），聚（赖氨酸），PAMAM树枝状聚合物，八胺树枝状聚合物和十六胺树枝状聚合物组成的组中; 并且其中Y选自 - （CH 2）2 - ， - （CH 2）2 -O-（CH 2）2 - ， - （CH 2）2 -O - （CH 2）2 -O - （CH 2）2 - 和 - （CH 2）3 -NHC（O） - （CH 2）6 -C（O）NH-（CH 2）3 - 可用于核酸递送应用。 式（I）的聚缩醛优选通过使适当的二醇和二乙烯基醚反应来制备。 在优选的实施方案中，在式（I）的聚缩醛和多核苷酸之间形成的络合物可用作转染试剂。

    Hydroxyphenyl cross-linked macromolecular network and applications thereof
    4.
    发明申请
    Hydroxyphenyl cross-linked macromolecular network and applications thereof 有权
    羟基苯基交联大分子网络及其应用

    公开(公告)号：US20040147673A1

    公开(公告)日：2004-07-29

    申请号：US10753779

    申请日：2004-01-08

    Inventor： Anthony Calabro ,  Richard A. Gross ,  Aniq B. Darr

    IPC: C08G063/48 ,  C08G063/91

    CPC classification number: A61L27/52 ,  A61K47/34 ,  A61K47/36 ,  A61K47/42 ,  A61L27/14 ,  C08G63/81 ,  C08G73/02 ,  C08J3/075 ,  C08L101/14

    Abstract: A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, such as artificial or synthetic cartilage. The network is made by first providing a polyamine or polycarboxylate macromolecule (having a plurality of amine or carboxylic acid groups respectively attached along the length of the molecule), reacting this macromolecule with a hydroxyphenyl compound having a free carboxylic acid group in the case of a polyamine or a free primary amine group in the case of a polycarboxylate, and substituting the hydroxyphenyl compound onto the macromolecule via a carbodiimide-mediated reaction pathway to provide a hydroxyphenyl-substituted macromolecule. This macromolecule is then linked to other such macromolecules via an enzyme catalyzed dimerization reaction between two hydroxyphenyl groups attached respectively to different macromolecules under metabolic conditions of temperature and pH. In a preferred embodiment, the macromolecular network is made up of tyramine-substituted hyaluronan molecules that are linked by dityramine bonds to provide a stable, coherent hydrogel with desired physical properties. A method of preparing such a network is also provided.

    Abstract translation: 提供二羟基苯基交联的大分子网络，其可用于人造或组织工程应用，例如人造或合成软骨。 通过首先提供多胺或多羧酸盐大分子（沿着分子长度分别具有多个胺或羧酸基团）制备网络，使该高分子与具有游离羧酸基团的羟基苯基化合物反应 多胺或游离的伯胺基，并且通过碳二亚胺介导的反应途径将羟基苯基化合物取代到大分子上以提供羟基苯基取代的大分子。 然后通过在温度和pH值的代谢条件下分别连接到不同的大分子上的两个羟基苯基之间的酶催化的二聚反应将该大分子连接到其它这样的大分子。 在优选的实施方案中，大分子网络由酪胺取代的透明质酸分子组成，其通过二苯胺键连接以提供具有所需物理性质的稳定的，连贯的水凝胶。 还提供了一种制备这种网络的方法。

    Immobilised cardiolipin probes
    7.
    发明申请
    Immobilised cardiolipin probes 审中-公开
    固定的心磷脂探针

    公开(公告)号：US20040096903A1

    公开(公告)日：2004-05-20

    申请号：US10468264

    申请日：2003-12-19

    Inventor： William Kenneth Lang ,  Andrew Bruce Holmes ,  Ze-Yi Lim ,  Stuart John Conway ,  Melloney Kate Johns

    IPC: G01N033/53 ,  C08G063/48 ,  C08G063/91

    CPC classification number: G01N33/92 ,  G01N33/564 ,  G01N33/6854

    Abstract: Probes comprising a cardiolipin derivative covalently attached to a solid phase, other than through an allylic oxygen, are described. Methods of making the probes are also described. A cardiolipin analogue which is amino-derivatised at the end of one of the fatty acid side chains is reacted with an activated ester attached to a solid support. The probes are useful for diagnosis of anti-phospholipid antibody syndrome (APS), and for identifying and purifying cardiolipin binding proteins.

    Abstract translation: 描述了除了通过烯丙氧以外共价连接到固相的心磷脂衍生物的探针。 还描述了制备探针的方法。 在一个脂肪酸侧链的末端被氨基衍生化的心磷脂类似物与附着在固体支持物上的活化酯反应。 该探针可用于诊断抗磷脂抗体综合征（APS），并用于鉴定和纯化心磷脂结合蛋白。

    Grafting polymerization of guar and other polysaccharides by electron beams
    8.
    发明申请
    Grafting polymerization of guar and other polysaccharides by electron beams 有权
    通过电子束将瓜尔胶和其他多糖接枝聚合

    公开(公告)号：US20040072947A1

    公开(公告)日：2004-04-15

    申请号：US10607079

    申请日：2003-06-25

    Inventor： Leo Zhaoqing Liu ,  Christian Priou

    IPC: C08G063/48 ,  C08G063/91

    CPC classification number: A61K8/91 ,  A61Q19/00 ,  C08F251/00 ,  C08F251/02 ,  C08F230/02 ,  C08F220/60

    Abstract: A method of grafting galactomannan-type polysaccharide polymers, preferably guar, to a functional group by irradiation with high energy electron beams in the presence of an unsaturated monomer-compressing the described functional group. The method may include the depolymerization of the grafted polymer to a pre-selected low molecular weight. The preferred galactomannans for treatment according to this method are guar gum, guar splits and hydroxypropyl guar. In a preferred embodiment the guar gum is also depolymerized, preferably to a molecular weight of below about 700,000 Daltons, and most preferably to a molecular weight of between about 100,000 Daltons to about 250,000 Daltons. The depolymerized guar most preferably has a polydispersity of less than about 3.0 and is useful in oil well fracturing to enhance oil production.

    Abstract translation: 通过在不饱和单体的存在下用高能电子束照射压缩所述官能团，将半乳甘露聚糖型多糖聚合物（优选瓜尔胶）接枝到官能团上的方法。 该方法可以包括将接枝聚合物解聚成预选择的低分子量。 根据该方法治疗的优选的半乳甘露聚糖是瓜尔胶，瓜尔胶和羟丙基瓜尔胶。 在优选的实施方案中，瓜尔胶也被解聚，优选分子量低于约700,000道尔顿，最优选分子量为约100,000道尔顿至约250,000道尔顿。 解聚瓜尔胶最好具有小于约3.0的多分散性，并且可用于油井压裂以提高产油量。

    Physiologically active substance-measuring reagent and method for measuring physiologically active substance
    10.
    发明申请
    Physiologically active substance-measuring reagent and method for measuring physiologically active substance 审中-公开
    生理活性物质测定试剂和生理活性物质测定方法

    公开(公告)号：US20040018564A1

    公开(公告)日：2004-01-29

    申请号：US10627732

    申请日：2003-07-28

    Applicant: JSR CORPORATION

    Inventor： Kiyoshi Kasai ,  Tohru Masukawa

    IPC: G01N033/53 ,  C08G063/91 ,  C08G063/48

    CPC classification number: G01N33/54346 ,  C08F290/062

    Abstract: A physiologically active substance-measuring reagent and a method for measuring a substance to be measured using the reagent. The physiologically active substance-measuring reagent comprises particles of a support polymer obtained by radical emulsion polymerization of the components (1), (2) and (3) as described herein above, and a physiologically active substance having an interaction with a substance to be measured, supported on the particles.

    Abstract translation: 生理活性物质测定试剂和使用该试剂测定待测物质的方法。 生理活性物质测量试剂包含通过上述组分（1），（2）和（3）的自由基乳液聚合获得的载体聚合物颗粒和与物质相互作用的生理活性物质 测量，支撑在颗粒上。

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