专利检索 ap:("F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.") AND inv:"Jordi De Mier Vinue" 第 1 页

1.

发明授权
Highly stable crystalline Eltrombopag monoethanolamine salt form D1 有权

公开(公告)号：US11267791B2

公开(公告)日：2022-03-08

申请号：US17263642

申请日：2019-07-25

申请人： F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.

发明人： Nicolas Tesson , Jordi De Mier Vinue , Paolo Stabile , Pierluigi Padovan , Matteo De Poli , Angelo Restelli

IPC分类号： C07D231/46

摘要： Object of the present invention is a highly stable crystalline form of Eltrombopag (ETP) monoethanolamine salt, named Form D1, having the highest thermodynamically stability with excellent non-hygroscopicity, and particularly well suitable for pharmaceutical purposes, with related process.

2.

发明授权
Crystalline Eltrombopag monoethanolamine salt form D 有权

公开(公告)号：US11214547B2

公开(公告)日：2022-01-04

申请号：US17263636

申请日：2019-07-25

申请人： F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.

发明人： Nicolas Tesson , Jordi De Mier Vinue , Paolo Stabile , Pierluigi Padovan , Matteo De Poli , Angelo Restelli

IPC分类号： C07D231/46

摘要： Object of the present invention is a better crystalline form of Eltrombopag (ETP) monoethanolamine salt, named Form D, stable, suitable for pharmaceutical purposes, and with the highest solubility in water and excellent non-hygroscopicity, then the related process and intermediates thereof.