公开(公告)号：US11434197B2

公开(公告)日：2022-09-06

申请号：US17059594

申请日：2019-06-07

申请人： F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.

发明人： Stefano Fogal ,  Paolo Stabile ,  Pierluigi Padovan ,  Matteo De Poli ,  Angelo Restelli

IPC分类号： C07C227/20 ,  C12N9/04 ,  C07C227/18 ,  C07C271/22 ,  C07C269/06 ,  C12P13/04 ,  C07C229/36

摘要： The present invention relates to a process for the preparation of Droxidopa by means of an improved enzymatic reduction of a compound of formula (II): (II), wherein R1, R2 is independent hydrogen, acetyl, R3 is hydrogen, a C1-C4 linear or branched alkyl group and R4 is hydrogen or an amine protecting group.

公开(公告)号：US11267791B2

公开(公告)日：2022-03-08

申请号：US17263642

申请日：2019-07-25

申请人： F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.

发明人： Nicolas Tesson ,  Jordi De Mier Vinue ,  Paolo Stabile ,  Pierluigi Padovan ,  Matteo De Poli ,  Angelo Restelli

IPC分类号： C07D231/46

摘要： Object of the present invention is a highly stable crystalline form of Eltrombopag (ETP) monoethanolamine salt, named Form D1, having the highest thermodynamically stability with excellent non-hygroscopicity, and particularly well suitable for pharmaceutical purposes, with related process.

公开(公告)号：US11214547B2

公开(公告)日：2022-01-04

申请号：US17263636

申请日：2019-07-25

申请人： F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.

发明人： Nicolas Tesson ,  Jordi De Mier Vinue ,  Paolo Stabile ,  Pierluigi Padovan ,  Matteo De Poli ,  Angelo Restelli

IPC分类号： C07D231/46

摘要： Object of the present invention is a better crystalline form of Eltrombopag (ETP) monoethanolamine salt, named Form D, stable, suitable for pharmaceutical purposes, and with the highest solubility in water and excellent non-hygroscopicity, then the related process and intermediates thereof.