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1.发明授权公开(公告)号：US08975408B2
公开(公告)日：2015-03-10
申请号：US14158939
申请日：2014-01-20
发明人： Gianni Gottardo , Pierluigi Padovan , Sergio Osti
IPC分类号： C07D215/38 , A61K31/04 , C07D471/04 , C07D401/04
CPC分类号： C07D471/04 , C07D401/04
摘要： Methods for producing moxifloxacin hydrochloride compounds having very low levels of impurities are provided. Compounds produced using such methods and pharmaceutical compositions including such compounds are also provided.
摘要翻译： 提供了生产具有非常低的杂质含量的盐酸莫西沙星化合物的方法。 还提供了使用这些方法生产的化合物和包括这些化合物的药物组合物。
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2.发明申请MOXIFLOXACIN HYDROCHLORIDE COMPOUNDS AND INTERMEDIATES AND METHODS FOR MAKING SAME 有权MOXIFLOXACIN HYDROCHLORIDE化合物及其中间体及其制备方法公开(公告)号：US20140135501A1
公开(公告)日：2014-05-15
申请号：US14158939
申请日：2014-01-20
发明人： Gianni Gottardo , Pierluigi Padovan , Sergio Osti
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07D401/04
摘要： Methods for producing moxifloxacin hydrochloride compounds having very low levels of impurities are provided. Compounds produced using such methods and pharmaceutical compositions including such compounds are also provided.
摘要翻译： 提供了生产具有非常低的杂质含量的盐酸莫西沙星化合物的方法。 还提供了使用这些方法生产的化合物和包括这些化合物的药物组合物。
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公开(公告)号：US09606089B2
公开(公告)日：2017-03-28
申请号：US14482770
申请日：2014-09-10
IPC分类号： A61K31/517 , C07D405/10 , G01N30/86 , G01N30/06
CPC分类号： G01N30/8631 , C07D239/94 , C07D405/04 , G01N30/06
摘要： Impurities of lapatinib such as N-{3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazoline-4-amine compound of formula (I) or a salt thereof: and analytical methods for identifying and quantifying such impurities of Lapatinib and salts thereof are provided. Also provided is Lapatinib containing less than about 0.05 percent of this and related impurities and methods for preparing such pure forms of Lapatinib.
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