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公开(公告)号:US09428442B2
公开(公告)日:2016-08-30
申请号:US14869065
申请日:2015-09-29
发明人: Siro Serafini , Pierluigi Padovan
IPC分类号: C07C213/08 , C07F9/6574
CPC分类号: C07C213/08 , C07B2200/09 , C07F9/65744 , C07C217/14
摘要: An improved process for the preparation of the active pharmaceutical ingredient Clomiphene and, in particular, trans-Clomiphene, using acetic acid or trifluoroacetic acid is disclosed.
摘要翻译: 公开了改进的制备活性药物成分的方法,使用乙酸或三氟乙酸克罗米芬,特别是反式克罗米芬。
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公开(公告)号:US20160152551A1
公开(公告)日:2016-06-02
申请号:US14869065
申请日:2015-09-29
发明人: Siro Serafini , Pierluigi PADOVAN
IPC分类号: C07C213/08 , C07F9/6574
CPC分类号: C07C213/08 , C07B2200/09 , C07F9/65744 , C07C217/14
摘要: An improved process for the preparation of the active pharmaceutical ingredient Clomiphene and, in particular, trans-Clomiphene, using acetic acid or trifluoroacetic acid is disclosed.
摘要翻译: 公开了改进的制备活性药物成分的方法,使用乙酸或三氟乙酸克罗米芬,特别是反式克罗米芬。
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公开(公告)号:US09845293B2
公开(公告)日:2017-12-19
申请号:US15515863
申请日:2016-02-23
IPC分类号: C07D223/22 , C07D223/26
CPC分类号: C07D223/26 , B01J2231/643 , B01J2540/32 , C07D223/28
摘要: Object of the present invention is an improved process for the preparation of Elsicarbazepine and Eslicarbazepine acetate by means of chiral Ruthenium catalysts.
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