-
公开(公告)号：US20180016493A1
公开(公告)日：2018-01-18
申请号：US15548774
申请日：2016-02-04
发明人： Ramunas Lygaitis , Reinhard Scholz , Olaf Zeika , Sebastian Reineke , Karl Leo , Simone Hofmann , Martin Oberlaender
IPC分类号： C09K11/06 , C07D209/86 , C07D215/06 , C07D219/02 , C07D223/22 , C07D235/18 , C07D265/36 , H01L51/00 , C07D519/00 , C07D209/08 , C07D401/14 , C07D279/22 , C07D279/16 , C07D265/38 , C07D487/04 , H01L51/50
CPC分类号： C09K11/06 , C07D209/08 , C07D209/86 , C07D215/06 , C07D219/02 , C07D223/22 , C07D235/18 , C07D265/36 , C07D265/38 , C07D279/16 , C07D279/22 , C07D401/14 , C07D487/04 , C07D519/00 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , C09K2211/1022 , C09K2211/1029 , C09K2211/1033 , C09K2211/1037 , C09K2211/1044 , C09K2211/1059 , H01L51/001 , H01L51/0067 , H01L51/0071 , H01L51/0072 , H01L51/0097 , H01L51/5012 , H01L51/5056 , H01L2251/5338 , Y02E10/549
摘要： The present invention relates to compounds of the formula (I) where C, D, A, m and n are as defined herein, and to their use in optoelectronic components and to optoelectronic components comprising them.
-
公开(公告)号：US08987321B2
公开(公告)日：2015-03-24
申请号：US13928691
申请日：2013-06-27
发明人： Timothy L. MacDonald , Jerry L. Nadler , Peng Cui
IPC分类号： A61K31/405 , C07D209/08 , A61K31/538 , C07C215/68 , C07C219/32 , C07D209/80 , C07D221/08 , C07D223/22 , C07D241/08 , C07D241/18 , C07D249/12 , C07D253/04 , C07D265/26 , C07D265/36 , C07D265/38 , C07D275/04 , C07D279/22 , C07D487/04 , A61K31/404 , A61K31/4196 , A61K31/495 , A61K31/502 , A61K31/53
CPC分类号： A61K31/538 , A61K31/404 , A61K31/405 , A61K31/4196 , A61K31/495 , A61K31/502 , A61K31/53 , C07C215/68 , C07C219/32 , C07D209/08 , C07D209/80 , C07D221/08 , C07D223/22 , C07D241/08 , C07D241/18 , C07D249/12 , C07D253/04 , C07D265/26 , C07D265/36 , C07D265/38 , C07D275/04 , C07D279/22 , C07D487/04
摘要： The present invention provides analogs of a Lysofylline (LSF), and synthetic methods for the preparation of such analogs. The have the active side chain moiety (5-R-hydroxyhexyl) of LSF and can have greater potency and oral bioavailability than LSF.
摘要翻译： 本发明提供了类似物溶血素（LSF）的类似物，以及制备这类类似物的合成方法。 具有LSF的活性侧链部分（5-R-羟基己基），并且可以具有比LSF更大的效力和口服生物利用度。
-
公开(公告)号：US20090082335A1
公开(公告)日：2009-03-26
申请号：US12233743
申请日：2008-09-19
申请人： Anthony W. Czarnik
发明人： Anthony W. Czarnik
IPC分类号： A61K31/55 , C07D223/22 , A61P25/00
CPC分类号： C07D223/28
摘要： The present application describes deuterium-enriched oxcarbazepine, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
摘要翻译： 本申请描述了富含钌的奥卡西平，其药学上可接受的盐形式，以及使用其的治疗方法。
-
公开(公告)号：US07125987B2
公开(公告)日：2006-10-24
申请号：US11153370
申请日：2005-06-16
IPC分类号： C07D223/22
CPC分类号： C07D223/26 , C07D223/28
摘要： A process for preparing Oxcarbazepine III comprising: a) reacting oximinostilbene IV with chlorosulfonyl isocyanate in an inert organic solvent and isolating compound V b) hydrolyzing compound V to form crude Oxcarbazepine III c) purifying oxcarbazepine.
摘要翻译： 一种制备奥卡西平III的方法，包括：a）使肟基芪Ⅳ与氯代磺酰基异氰酸酯在惰性有机溶剂中反应并分离化合物Ⅴb）水解化合物V以形成粗制的奥卡西平III，c）纯化奥卡西平。
-
![Dibenzo [b,f]azepine intermediates](/abs-image/US/2006/09/26/US07112673B2/abs.jpg.150x150.jpg)
公开(公告)号：US07112673B2
公开(公告)日：2006-09-26
申请号：US10182980
申请日：2001-02-07
IPC分类号： C07D223/22
CPC分类号： C07D223/22
摘要： The invention relates to new processes for the preparation of the pharmaceutical oxcarbazepine, as well as novel intermediates prepared by or used for said processes, and the preparation of said intermediates.
摘要翻译： 本发明涉及制备奥卡西平药物的新方法，以及由所述方法制备或用于所述方法的新型中间体以及所述中间体的制备。
-
公开(公告)号：US20050282797A1
公开(公告)日：2005-12-22
申请号：US11153370
申请日：2005-06-16
IPC分类号： A61K31/55 , C07D223/18 , C07D223/22 , C07D223/26 , C07D223/28 , C07D223/30
CPC分类号： C07D223/26 , C07D223/28
摘要： A process for preparing Oxcarbazepine III comprising: a) reacting oximinostilbene IV with chlorosulfonyl isocyanate in an inert organic solvent and isolating compound V b) hydrolyzing compound V to form crude Oxcarbazepine III c) purifying oxcarbazepine.
摘要翻译： 一种制备奥卡西平III的方法，包括：a）使肟基芪Ⅳ与氯代磺酰基异氰酸酯在惰性有机溶剂中反应并分离化合物Ⅴb）水解化合物V以形成粗制的奥卡西平III，c）纯化奥卡西平。
-
7.发明申请Derivatives of 4-hydroxybutanoic acid and of its higher homologue as ligands of $g(g)-hydroxybutyrate (ghb) receptors, pharmaceutical compositions containing same and pharmaceutical uses 审中-公开4-羟基丁酸的衍生物及其高同系物作为$ g（g） - 羟基丁酸（ghb）受体的配体，含有它们的药物组合物和药物用途公开(公告)号：US20050113366A1
公开(公告)日：2005-05-26
申请号：US10432692
申请日：2001-11-16
申请人： Jean-Jacques Bourguignon , Michel Maitre , Evelyne Klotz , Martine Schmitt , Serge Gobaille , Jean-Paul Macher
发明人： Jean-Jacques Bourguignon , Michel Maitre , Evelyne Klotz , Martine Schmitt , Serge Gobaille , Jean-Paul Macher
IPC分类号： A61P25/00 , A61P25/08 , A61P25/18 , A61P25/24 , C07C59/48 , C07C59/56 , C07C59/64 , C07C229/42 , C07C233/54 , C07C259/06 , C07D207/34 , C07D207/48 , C07D209/08 , C07D209/18 , C07D209/34 , C07D209/42 , C07D209/86 , C07D213/55 , C07D215/22 , C07D215/227 , C07D215/233 , C07D223/22 , C07D241/42 , C07D307/33 , C07D307/58 , C07D307/79 , C07D307/91 , C07D319/06 , C07D319/18 , C07D327/08 , C07D333/24 , C07D333/60 , C07D333/76 , C07D405/04 , C07D471/04 , C07D487/04 , A61K31/55 , A61K31/503 , A61K31/53 , A61K31/5513
CPC分类号： C07D215/227 , C07C59/48 , C07C59/56 , C07C59/64 , C07C229/42 , C07C233/54 , C07C259/06 , C07D207/34 , C07D207/48 , C07D209/08 , C07D209/18 , C07D209/34 , C07D209/42 , C07D209/86 , C07D213/55 , C07D215/233 , C07D223/22 , C07D241/42 , C07D307/33 , C07D307/58 , C07D307/79 , C07D307/91 , C07D319/06 , C07D319/18 , C07D327/08 , C07D333/24 , C07D333/60 , C07D333/76 , C07D405/04 , C07D471/04 , C07D487/04
摘要： The invention concerns the field of synthesis organic chemistry applied to the pharmaceutical field and concerns novel derivatives of 4-hydroxybutanoic acid and its higher homologue, 5-hydroxypentanoic acid, their crotonic homologues, pharmaceutical compositions containing them and their pharmaceutical uses. Said novel derivatives are capable of binding with γ-hydroxybutyrate (GHB)-specific receptors and hence capable of exhibiting agonist or antagonist properties, in particular for treating sleep disorders, anxiety and general diseases of the central nervous system. The invention also concerns compounds of general formula (I) wherein the substituents are as defined in the description.
摘要翻译： 本发明涉及应用于药物领域的合成有机化学领域，涉及4-羟基丁酸及其高级同系物5-羟基戊酸，其巴豆酸同系物，含有它们的药物组合物及其药物用途的新型衍生物。 所述新型衍生物能够与γ-羟基丁酸酯（GHB）特异性受体结合，因此能够表现出激动剂或拮抗剂特性，特别是用于治疗中枢神经系统的睡眠障碍，焦虑和一般疾病。 本发明还涉及通式（I）的化合物，其中取代基如说明书中所定义。
-
公开(公告)号：US6043247A
公开(公告)日：2000-03-28
申请号：US842800
申请日：1997-04-16
IPC分类号： C07C59/68 , C07C59/86 , C07D209/22 , C07D209/86 , C07D215/38 , C07D223/22 , C07D233/26 , C07D295/155 , C07D307/79 , A01N43/54 , A01N37/10 , C07C69/76 , C07C229/00
CPC分类号： C07D215/38 , C07C59/68 , C07C59/86 , C07D209/22 , C07D209/86 , C07D223/22 , C07D233/26 , C07D295/155 , C07D307/79
摘要： The present invention relates to novel substituted acrylic acids, to methods for their preparation, compositions containing them, and their use for treatment of human and animal disorders, to their use for purification of proteins or glycoproteins, and to their use in diagnosis. The invention also relates to modulation of the activity of molecules with phospho-tyrosine recognition units, including protein tyrosine phosphatases (PTPases) and proteins with Src-homology-2 domains, in in vitro systems, microorganisms, eukaryotic cells, whole animals and human beings.
摘要翻译： 本发明涉及新型取代丙烯酸，其制备方法，含有它们的组合物及其用于治疗人和动物病症的用途，其用于蛋白质或糖蛋白的纯化及其在诊断中的应用。 本发明还涉及在体外系统，微生物，真核细胞，整个动物和人类中调节具有磷酸 - 酪氨酸识别单元的分子的活性，包括蛋白酪氨酸磷酸酶（PTP酶）和具有Src同源性-2结构域的蛋白质 。
-
公开(公告)号：US5895815A
公开(公告)日：1999-04-20
申请号：US942489
申请日：1997-10-02
申请人： Gunter Eichberger , Walter Raml
发明人： Gunter Eichberger , Walter Raml
IPC分类号： C07D223/22 , C07D223/26
CPC分类号： C07D223/22 , C07D223/26
摘要： Process for the purification of 5H-dibenz�b,f!a-zepine, which comprises evaporating 5H-dibenz�b, f!azepine under reduced pressure from a reaction mixture obtained by catalytic dehydrogenation of 10,11-dihydro-5H-dibenz-�b,f!azepine in the 1st step and depositing it as a solid, suspending the deposited product in an aromatic hydrocarbon in the 2nd step and then isolating pure 5H-dibenz�b,f!azepine.
摘要翻译： 纯化5H-二苯并[b，f] a-吖庚因的方法，其包括在减压下从10,11-二氢-5H-二苯并二恶烷催化脱氢得到的反应混合物中蒸发5H-二苯并[b，f]氮杂 - [b，f]吖庚因，并将其作为固体沉积，在第二步中将沉积的产物悬浮在芳族烃中，然后分离纯的5H-二苯并[b，f]吖庚因。
-
公开(公告)号：US5786353A
公开(公告)日：1998-07-28
申请号：US893497
申请日：1997-07-11
申请人： Jay Donald Albright , Marvin Fred Reich , Fuk-Wah Sum , Xuemei Du
发明人： Jay Donald Albright , Marvin Fred Reich , Fuk-Wah Sum , Xuemei Du
IPC分类号： C07D221/12 , C07D221/18 , C07D223/18 , C07D223/20 , C07D223/22 , C07D223/28 , C07D225/00 , C07D225/08 , C07D243/18 , C07D243/38 , C07D267/18 , C07D267/20 , C07D279/30 , C07D281/16 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04 , A61K31/55 , A61K31/675 , C07D223/00 , C07D267/02
CPC分类号： C07D221/12 , C07D221/18 , C07D223/18 , C07D223/20 , C07D223/22 , C07D223/28 , C07D225/00 , C07D225/08 , C07D243/18 , C07D243/38 , C07D267/18 , C07D267/20 , C07D279/30 , C07D281/16 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
摘要： Tricyclic compounds of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V.sub.1 and/or V.sub.2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and processes for preparing such compounds.
-
-
-
-
-
-
-
-
-
搜索结果
152 条记录 (耗时 0.026 秒)
